Regulation of very primitive, multipotent, hemopoietic cells by hemopoietin-1

Stanley, E. Richard; Bartocci, A.; Patinkin, Deborah; Rosendaal, Martin; Bradley, T. R.

doi:10.1016/0092-8674(86)90781-6

Cited by 258 publications

(74 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As shown previously (32)(33)(34)(35), neither EGF, basic or acidic FGF, PDGF, or insulin had any effect on the growth of prostatic carcinoma cells. TGF-beta has been shown to be stimulatory for cells ofmesen- (31,(38)(39)(40)(41)(42)(43)(44). To determine whether combinations of hematopoietic factors would promote an increased stimulation of prostatic carcinoma cell growth, we incubated PC-3 cells with mixtures of two or more factors.…”

Section: Resultsmentioning

confidence: 99%

Stimulation of human prostatic carcinoma cell growth by factors present in human bone marrow.

Chackal-Roy¹,

Niemeyer²,

Moore³

et al. 1989

J. Clin. Invest.

110

View full text Add to dashboard Cite

Malignant prostatic carcinoma, a major cause of cancer mortality in males, most often metastasizes to secondary sites in bone. Frequently, the growth rate of the secondary tumor in bone marrow is considerably greater than that of the slowly growing primary prostatic tumor. We now report that two lines of human prostatic carcinoma cells proliferate in response to conditioned media from unstimulated human, rat, or bovine bone marrow. Nonprostatic tumor cell lines showed little or no growth response to the same medium.The proliferative activity found in bone marrow was not duplicated by any of a variety of purified growth factors including epidermal growth factor (EGF), acidic or basic fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), transforming growth factor (TGF) alpha or beta, interleukins 1, 2, 3, 4 or 6, granulocyte (G), macrophage (M) or granulocyte-macrophage (GM) colony stimulating factor (CSF). Whereas a mixture of G-CSF, M-CSF, and IL 3 produced a mitogenic response in the prostatic carcinoma cells, these three factors were not present in our bone marrow samples in sufficient quantities to promote the observed proliferative response. To further identify the cellular source of the proliferative activity present in bone marrow-conditioned medium, we tested conditioned media made from human bone marrow stromal cells. The stromal cell conditioned medium stimulated increased growth of the prostatic carcinoma cells to levels equivalent to those observed with the bone marrow conditioned medium. These results suggest that novel mitogenic factors that are produced by bone marrow stromal cells and remain in the bone marrow cavity may account, in part, for the preferential growth of prostatic metastases in bone.

show abstract

Section: Resultsmentioning

confidence: 99%

Stimulation of human prostatic carcinoma cell growth by factors present in human bone marrow.

Chackal-Roy¹,

Niemeyer²,

Moore³

et al. 1989

J. Clin. Invest.

110

View full text Add to dashboard Cite

show abstract

“…Infusions of IL-1 have been reported to cause neutrophilia in mice (17), while recently, it was also reported (18,19) that IL-1 constituted one component of hemopoietin-1, which is believed to induce mouse stem cells to become responsive to other CSFs . The leukemic cells in our study possessed CD7, CD25, and CDw41 antigens, suggesting that they originated from pluripotent stem cells.…”

Section: Discussionmentioning

confidence: 99%

Autocrine stimulation of interleukin 1 beta in acute myelogenous leukemia cells.

Sakai

Hattori

Matsuoka

et al. 1987

The Journal of Experimental Medicine

View full text Add to dashboard Cite

A significant increase in CD25 antigen-positive cells by IL-1 was observed in cells of a patient with M7 acute myelogenous leukemia. Basal proliferation and expression of CD25 antigen by the M7 leukemic cells were inhibited by addition of anti-IL-1 beta antibody in a dose-dependent manner, but not by rabbit anti-IL-1 alpha antibody. Culture supernatants of these leukemic cells contained IL-1 activity, which was specifically inhibited by addition of anti-IL-1 beta antibody, and Northern blot analysis detected intracellular IL-1 beta mRNA. These results indicated that autocrine secretion of IL-1 beta was involved in proliferation of some myelogenous leukemic cells.

show abstract

“…Hemopoietin-1 (H-1), previously termed synergistic factor, was first detected by its ability to induce stem cells to become responsive to other hematopoietic growth factors (46)(47)(48). H-l has been shown to be identical to interleukin la (47,48).…”

Section: Discussionmentioning

confidence: 99%

Characterization of a human hematopoietic progenitor cell capable of forming blast cell containing colonies in vitro.

et al. 1988

View full text Add to dashboard Cite

A hematopoietic cell (CFU-B1) capable of producing blast cell containing colonies in vitro was detected using a semisolid culture system. The CFU-B1 has the capacity for self-renewal and commitment to a number of hematopoietic lineages. Monoclonal antibody to the human progenitor cell antigen-i (HPCA-1) and a monoclonal antibody against the major histocompatibility class II antigen (HLA-DR) were used with fluorescence activated cell sorting to phenotype the CFU-B1. The CFU-B1 was found to express MylO but not HLA-DR antigen; experiments using complement-dependent cytotoxicity to eliminate DR positive cells confirmed this finding. Pretreatment of marrow cells with two chemotherapeutic agents, 5-fluorouracil and 4-hydroperoxycyclophosphamide facilitated detection of CFU-B1 derived colonies, while diminishing or totally inhibiting colony formation by other hematopoietic progenitor cells. CFU-Bl-derived colony formation was dependent upon the addition of exogenous hematopoietic growth factors. Media conditioned either by the human bladder carcinoma cell line 5637 or lectin stimulated leukocytes, as well as recombinant granulocyte-macrophage colony stimulating factor, interleukin 3 or interleukin la promoted blast cell colony formation. By contrast, neither recombinant erythropoietin, recombinant interleukin 4, purified macrophage colony stimulating factor or recombinant granulocyte colony-stimulating factor alone promoted blast cell colony formation.

show abstract

Regulation of very primitive, multipotent, hemopoietic cells by hemopoietin-1

Cited by 258 publications

References 19 publications

Stimulation of human prostatic carcinoma cell growth by factors present in human bone marrow.

Stimulation of human prostatic carcinoma cell growth by factors present in human bone marrow.

Autocrine stimulation of interleukin 1 beta in acute myelogenous leukemia cells.

Characterization of a human hematopoietic progenitor cell capable of forming blast cell containing colonies in vitro.

Contact Info

Product

Resources

About