Regulation of vascular endothelial growth factor expression by insulin-like growth factor-I in endometrial adenocarcinoma cells

Human chondrosarcoma secretes vascular endothelial growth factor to induce tumor angiogenesis and stores basic fibroblast growth factor for regulation of its own growth

“…The VEGF 145 isoform was detected by RT-PCR (failed to be detected by Northern blot analysis) in endometrial adenocarcinoma cells stimulated with insulin-like growth factor-1. 44 Although previous studies 36,42 could not detect VEGF 145 except in female inherent tissue, we obtained the first finding that the VEGF 145 isoform is also exhibited in a male chondrosarcoma. VEGF 145 has been reported as a specific protein that binds to ECM produced in corneal endothelial cells by a different mechanism.…”

Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo

“…However, we cannot exclude the possibility that IGFs might also have indirect effects in the induction of lymphangiogenesis via other growth factor͞ receptor systems. For example, the IGF-1͞IGF-1R signaling system has been shown to up-regulate both mRNA and protein expression of VEGF-A, a known lymphangiogenistic growth factor (24,(38)(39)(40)43). Hence, it is possible that the IGFs could indirectly induce lymphoproliferation via up-regulation of VEGF-A expression (7,8,10).…”

“…IGF-1R, the functional receptor for IGFs, is expressed on isolated hemovascular endothelial cells and newly formed blood microvessels (36,37). In addition to its direct role in stimulation of hemangiogenesis, the IGF-1͞IGF-1R signaling system can also up-regulate VEGF expression and thus indirectly induce neovascularization (24,(38)(39)(40). In contrast however, nothing is known currently about the roles of IGFs and their receptors in the lymphatic vasculature.…”

Does IGF-1 play a role in the biology of endometrial cancer?

“…They found a dose-and time-dependent increase in VEGF mRNA expression, and an increased concentration of its protein product after 24 and 48 hour-incubation of the HEC-1A cell line with exogenous IGF-1. These authors suggested that estrogen-dependent activation of the IGF-1 autocrine loop may result in tumor growth by stimulating the process of neoangiogenesis [22]. The presence of IGF-1R receptors were demonstrated both, in EC tissues and healthy endometrium (Table 2) [20,23,24].…”