1997
DOI: 10.2527/1997.7561621x
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Regulation of uterine immune function during the estrous cycle and in response to infectious bacteria in sheep.

Abstract: Uterine infections are a major reproductive problem in livestock. We conducted two experiments to investigate factors that may modulate uterine responses to infectious bacteria. In Exp. 1, ewes received intrauterine inoculations of either saline or bacteria (75 x 10(7) cfu of Actinomyces pyogenes and 35 x 10(7) cfu of Escherichia coli) on either d 0 or 7 of the estrous cycle. Vena caval samples containing uteroovarian blood were collected twice daily from 12 h before until 6 d after inoculation. Only ewes inoc… Show more

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Cited by 51 publications
(63 citation statements)
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“…It is also known that endometritis prevents release of luteolytic PGF2a from the uterus [21] and often induces a persistent corpus luteum [32]. Our data showed that the number of cows with a persistent corpus luteum in the ovulated and anovulated groups were identical.…”
Section: Discussionsupporting
confidence: 69%
“…It is also known that endometritis prevents release of luteolytic PGF2a from the uterus [21] and often induces a persistent corpus luteum [32]. Our data showed that the number of cows with a persistent corpus luteum in the ovulated and anovulated groups were identical.…”
Section: Discussionsupporting
confidence: 69%
“…In such events, intensive therapy is not always successful. The main cause of these failures is loss of the contraction ability of the uterine muscular layer (Olson et al 1984;Hussain 1989;Hussain and Daniel 1992;De Winter et al 1995;Ramadan et al 1997).…”
Section: Contractile Activity Uterus Endometritis Pge 2 Pge 2 -Amentioning
confidence: 99%
“…O ne of the long-standing enigmas of reproductive biology is why the fetus is not rejected by the mother's immune system (1)(2)(3). Many explanations for this phenomenon have been proposed and tested, including the idea of paternal antigen sequestration and reduced MHC expression (4,5), the possibility of local immune changes in the uterus (6,7), and a potential maternal shift from Th1 to Th2 immune responses (8)(9)(10). Although each of these mechanisms appears to play some role in protection of the fetus from the maternal immune system, none has been directly shown to be required.…”
mentioning
confidence: 99%