Regulation of UCP1, UCP2, and UCP3 mRNA Expression in Brown Adipose Tissue, White Adipose Tissue, and Skeletal Muscle in Rats by Estrogen

Pedersen, Steen B.; Bruun, Jens Meldgaard; Kristensen, Kurt; Richelsen, Bjørn

doi:10.1006/bbrc.2001.5763

Cited by 117 publications

(94 citation statements)

References 24 publications

(25 reference statements)

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“…Therefore, SNS-mediated thermogenesis in BAT, triggered by estrogen action on the leptinergic/melanocortin system, probably contributes to the effect of the hormone on energy dissipation. In this context, even if direct experimental evidence has never been reported, the important role played by BAT in estrogen-induced modifications in energy balance is supported by a series of observations reported here: i) ovariectomized animals, which become spontaneously obese, display atrophy of their BAT (Pedersen et al 2001). ii) BAT thermogenesis is mainly mediated by the melanocortin system.…”

Section: Estrogen and Melanocortin/leptin-mediated Thermogenesissupporting

confidence: 51%

Role of sex hormones in modulation of brown adipose tissue activity

Quarta

Mazza²,

Pasquali³

et al. 2012

Journal of Molecular Endocrinology

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The recent demonstration that metabolically active brown adipose tissue (BAT) is present with a high prevalence in humans undoubtedly represents one of the major advancements in the field of metabolic research in the last few years. The increasing interest in BAT is justified by preclinical observations highlighting an important role of this tissue in energy dissipation and metabolic clearance of substrates from the blood. These findings imply that stimulation of BAT activity may represent a new therapeutic approach for obesity and associated comorbidities. However, before proposing BAT as a target organ for therapeutics in a clinical setting, many further notions about BAT function and modulation need to be explored. Keeping in mind the importance of sex dimorphism in energy metabolism control under physiological and pathological conditions, sex hormones may play a relevant role in the regulation of BAT activity in both males and females. Much of the evidence acquired in the past supports the concept of an important role for different sex hormones in BAT thermogenesis and indicates that this tissue mediates the ability of sex hormones to modulate energy balance. These findings make it plausible that a modified interaction between BAT and sex hormones may contribute to the development and the maintenance of obesity and associated metabolic complications.Journal of Molecular Endocrinology (2012) 49, R1-R7

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Section: Estrogen and Melanocortin/leptin-mediated Thermogenesissupporting

confidence: 51%

Role of sex hormones in modulation of brown adipose tissue activity

Quarta

Mazza²,

Pasquali³

et al. 2012

Journal of Molecular Endocrinology

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“…Thus, in females, this lesser presence of ␣ 2A -AR, a receptor with high affinity for catecholamines and clearly involved in the inhibition of lipolysis (14), could be responsible for the higher thermogenic activity due to a lower inhibitory effect on thermogenic and lipolytic signal transduction pathway. Moreover, BAT of female rats has a more sensitive ␤ 3 -AR to NE signal (EC 50 10-fold lower for CGP12177A), leading to a higher signal for lipolytic and thermogenic activation with identical levels of NE.…”

Section: Discussionmentioning

confidence: 99%

Sex-dependent Thermogenesis, Differences in Mitochondrial Morphology and Function, and Adrenergic Response in Brown Adipose Tissue

Rodríguez‐Cuenca¹,

Pujol²,

Justo³

et al. 2002

Journal of Biological Chemistry

177

134

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Gender-related differences in brown adipose tissue (BAT) thermogenesis of 110-day-old rats were studied by determining the morphological and functional features of BAT. The adrenergic control was assessed by studying the levels of ␤ 3 -and ␣ 2A -adrenergic receptors (AR) and by determining the lipolytic response to norepinephrine (␤ 1 -, ␤ 2 -, ␤ 3 -, and ␣ 2 -AR agonist), isoprenaline (␤ 1 -, ␤ 2 -, and ␤ 3 -AR agonist), and CGP12177A (selective partial ␤ 3 -AR agonist but ␤ 1 -and ␤ 2 -AR antagonist) together with post-receptor agents, forskolin and dibutyryl cyclic AMP. The female rats that had greater oxygen consumption showed higher UCP1 content, a higher multilocular arrangement, and both longer cristae and higher cristae dense mitochondria in BAT indicating heightened thermogenic capacity and activity; this picture is accompanied by a more sensitive ␤ 3 -AR to norepinephrine signal (EC 50 10-fold lower for CGP12177A) and a lower expression of ␣ 2A -AR than male rats. Taken together, our results support the idea that the BAT hormonal environment could be involved in the control of different elements of lipolytic and thermogenic adrenergic pathways. Gender dimorphism is both at receptor (changing ␣ 2A -AR density and ␤ 3 -AR affinity) and post-receptor (modulating the links involved in the adrenergic signal transduction) levels. These changes in adrenergic control could be responsible, at least in part, both for the important mitochondrial recruitment differences and functional and morphological features of BAT in female rats under usual rodent housing temperatures.

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“…Data from several animal experiments clearly show that oestrogen deficiency in ovx rats may increase food intake (Gray and Wade, 1981;Pedersen et al, 2001) and decrease adipose tissue lipolysis (Darimont et al, 1997), spontaneous physical activity (Roy and Wade, 1975), and energy expenditure (Heine et al, 2000;Pedersen et al, 2001). Also, it has been shown that hypoestrogenemia in ovx rats causes central leptin insensitivity and increases hypothalamic neuropeptide Y levels and thereby contribute to excess fat accumulation (Ainslie et al, 2001).…”

Section: Menopause Hormonal Changes and Obesitymentioning

confidence: 99%

Ovarian function and obesity—Interrelationship, impact on women's reproductive lifespan and treatment options

Rachoń

Teede

2010

Molecular and Cellular Endocrinology

125

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Insulin resistance (IR) is a consequence of obesity, and in women it is often inextricably linked with ovarian function leading to clinical reproductive manifestations such as early menarche onset, subfertility and polycystic ovary syndrome (PCOS). Likewise, the dramatic fall in oestrogen production after menopause may contribute to weight gain and changes in adipose tissue distribution.Overall, women who are obese, especially those with reproductive complications including PCOS, have been identified as specific high risk subgroups for further progression through to prediabetes, type 2 diabetes mellitus (T2DM) and potentially cardiovascular disease (CVD). This review focuses on the interrelationship between the ovarian function and obesity as well as its treatment strategies.

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Regulation of UCP1, UCP2, and UCP3 mRNA Expression in Brown Adipose Tissue, White Adipose Tissue, and Skeletal Muscle in Rats by Estrogen

Cited by 117 publications

References 24 publications

Role of sex hormones in modulation of brown adipose tissue activity

Role of sex hormones in modulation of brown adipose tissue activity

Sex-dependent Thermogenesis, Differences in Mitochondrial Morphology and Function, and Adrenergic Response in Brown Adipose Tissue

Ovarian function and obesity—Interrelationship, impact on women's reproductive lifespan and treatment options

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