Regulation of transferrin gene expression

Zakin, Mario M.

doi:10.1096/fasebj.6.14.1426763

Cited by 62 publications

(43 citation statements)

References 40 publications

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“…Transferrin protein was decreased Ͼ5-fold at the early time point. Transferrin is the iron transport protein of vertebrate serum that is primarily, although not exclusively, synthesized in the liver (17 ). Transferrin mRNA concentrations are diminished by aflatoxin B-1 exposure in rats (18 ).…”

Section: Proteomics Resultsmentioning

confidence: 99%

Use of Proteomic Methods to Identify Serum Biomarkers Associated with Rat Liver Toxicity or Hypertrophy

Amacher¹,

Adler²,

Herath

et al. 2005

Clinical Chemistry

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Background: Our objectives were to identify serum marker proteins in rats that might serve as sensitive indicators of hepatomegaly, hepatocellular necrosis, or hepatobiliary injury and to use them to analyze data from a collaborative proteomics project. Methods: In each of 4 studies comprising the collaborative project, rats were given 1 of 4 compounds that target the liver through different mechanisms. Sera and liver samples were collected by terminal bleeds at 1 of 3 postdose time points. Sera were depleted of major secretory proteins and then separated into protein features by 2-dimensional gel electrophoresis (2DGE). Liver specimens were also processed and subjected to 2DGE. Protein spots that significantly increased or decreased in quantity after drug treatment were recovered, digested, analyzed by mass spectroscopy, and compared with available databases for identification. Criteria for further consideration were (a) temporal expression (i.e., increase or decrease at early, fulminant, or recovery periods), (b) known biological function, (c) probable hepatic origin, and (d) any previous association with toxicity in published studies. Markers that changed significantly at the early time point were important because of their potential sensitivity for signaling minimal damage. Results: Vitamin D-binding protein, paraoxonase, cellular retinol-binding protein, malate dehydrogenase, F-protein, and purine nucleoside phosphorylase were

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Section: Proteomics Resultsmentioning

confidence: 99%

Use of Proteomic Methods to Identify Serum Biomarkers Associated with Rat Liver Toxicity or Hypertrophy

Amacher¹,

Adler²,

Herath

et al. 2005

Clinical Chemistry

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“…The role of nodule and HCC iron content in Tf and Tf-R expression is not clear. Iron cell content may regulate Tf and Tf-R mRNA transcription, 34,38 although, in the case of Tf-R, iron is principally involved in posttranscriptional regulation of Tf-R gene expression by interaction with ''iron-responsive elements'' of Tf-R mRNA. [34][35][36][37] Total iron content in preneoplastic liver nodules is not significantly different from that in normal liver, and is associated with Tf and Tf-R overexpression, while a 160% increase in HCC is paralleled by Tf-R overexpression and marked decrease in Tf expression.…”

Section: Discussionmentioning

confidence: 99%

Transferrin and transferrin receptor gene expression and iron uptake in hepatocellular carcinoma in the rat

et al. 1998

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“…This novel finding is intriguing because, in the DESIR population, as in the other populations, plasma transferrin was negatively correlated with plasma ferritin (r ϭ Ϫ0.289, P Ͻ 0.001); a high iron load is reflected by high ferritin levels but decreased transferrin levels. Little is known about the regulation of transferrin (12). Plasma transferrin itself may be involved in the pathogenesis of insulin resistance because Vargas et al (13) have shown an antagonist effect of human transferrin on insulin action.…”

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confidence: 99%

Ferritin and Transferrin Are Both Predictive of the Onset of Hyperglycemia in Men and Women Over 3 Years

Fumeron

Péan²,

Driss³

et al. 2006

Diabetes Care

126

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OBJECTIVE -The aim of the present work was to determine, in a cohort of men and women, whether ferritin and transferrin were associated with glucose metabolism and whether they were predictive of the onset of hyperglycemia (impaired fasting glycemia or type 2 diabetes) after 3 years of follow-up.RESEARCH DESIGN AND METHODS -Among 4,501 subjects from the French Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort, 1,277 subjects (644 men and 633 women) were randomly selected for the analysis of iron biomarkers at baseline and at 3 years. In addition, to determine whether these parameters were relevant to pathological changes, all 231 subjects normoglycemic at baseline and hyperglycemic 3 years later were analyzed for iron biomarkers.RESULTS -At baseline, plasma ferritin concentrations were positively correlated with fasting insulin and fasting glucose in the 1,277 subjects. Although transferrin and ferritin were negatively correlated, transferrin was also positively correlated with fasting insulinemia. Baseline ferritin concentration was an independent predictor of an increase in insulin concentration over a 3-year period (P ϭ 0.002). Further, baseline ferritin and transferrin were independently associated with the onset of hyperglycemia over a 3-year period in the whole population (P Ͻ 0.001 for both) and in each sex.CONCLUSIONS -Although negatively correlated, both transferrin and ferritin were positively associated with the onset of abnormalities in glucose metabolism in a prospective study. These results further support the hypothesis of a causative role of iron metabolism in the onset of insulin resistance and type 2 diabetes.

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Regulation of transferrin gene expression

Cited by 62 publications

References 40 publications

Use of Proteomic Methods to Identify Serum Biomarkers Associated with Rat Liver Toxicity or Hypertrophy

Use of Proteomic Methods to Identify Serum Biomarkers Associated with Rat Liver Toxicity or Hypertrophy

Transferrin and transferrin receptor gene expression and iron uptake in hepatocellular carcinoma in the rat

Ferritin and Transferrin Are Both Predictive of the Onset of Hyperglycemia in Men and Women Over 3 Years

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