Regulation of Tissue Enzymes

Kochakian, Charles D.

doi:10.1007/978-3-642-66353-6_9

Cited by 3 publications

(2 citation statements)

References 102 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the mouse, testosterone and other androgens stimulate hypertrophy of the proximal tubule of the nephron and this effect is associated with an increase in many renal constituents [9]. One of the best studied androgen-responsive proteins is P-glucuronidase [3, 201, whose induction is mediated via androgen receptors [l, 2, 151.…”

Section: Discussionmentioning

confidence: 99%

Androgen Environment and β-Glucuronidase Activity in the Human Kidney

Corrales¹,

González-Buitrago²,

Pastor-encinas³

et al. 1988

Archives of Andrology

View full text Add to dashboard Cite

Basal @glucuronidase activity was measured in the cytosol of renal cortex in 10 women and nine men, and its levels were correlated to the concentrations of the main circulating androgens and to the cytoplasmic androgen receptor content. 0-Glucuronidase activity in women was similar to that found in men, despite blood testosterone levels being higher in the latter. The activity of the enzyme does not appear to be related to circulating levels of either testosterone or androstenedione. Only in men the androgen receptor content and dehydroepiandrosterone-sulphate levels were inversely correlated to 0-glucuronidase. In the human kidney cytosol there is no evidence of sexual dimorphism in basal 0-glucuronidase activity; whereas the total testosterone circulating levels do not seem to control the enzyme activity.

show abstract

Section: Discussionmentioning

confidence: 99%

Androgen Environment and β-Glucuronidase Activity in the Human Kidney

Corrales¹,

González-Buitrago²,

Pastor-encinas³

et al. 1988

Archives of Andrology

View full text Add to dashboard Cite

show abstract

“…Nevertheless, many of the compounds were explored in clinical trials and veterinary medicine (2,6). These compounds became popularly known as anabolic steroids but more accurately as anabolic-androgenic steroids (11).…”

mentioning

confidence: 99%

Role of the Mouse in the Delineation of the Anabolic‐Androgenic Action of Steroids

Kochakian

1994

FASEB j.

View full text Add to dashboard Cite

New Androgen-Stimulated Proteins in the Kidneys of Female Mice*

Mills¹,

Bardin²

1980

Endocrinology

View full text Add to dashboard Cite

Testosterone administration to female mice for 25 days produced a 70% increase in total kidney protein in both A/J and C57BL/6J mice. This is in contrast to the known androgen-responsive proteins, such as beta-glucuronidase and alcohol dehydrogenase, which each represent less than 1% of the total kidney proteins even after maximum stimulation. To investigate this discrepancy, we initiated a study to identify major proteins which increase with androgen treatment. Three new cytoplasmic proteins designated T1, T2, and T3 were found in different subcellular fractions of both A/J and C57BL/6J mice. T1 (43,000 daltons) and T2 (60,000 daltons) were found in the mitochondrial-lysosomal fraction of 25-day androgen-treated mice. T3 (54,000 daltons) was found in the microsomal fraction. Each of these proteins increased several-fold during androgen treatment, so that they were easily identified using sodium dodecyl sulfate polyacrylamide gel electrophoresis. By contrast, no major changes were noted in the soluble proteins. A nonhistone chromosomal protein of 54,000 mol wt (T4) was found in chromatin preparations from androgen-stimulated A/J mice. Additional studies with androgen-insensitive Tfm/Y mice and with various hormones indicated that stimulation of the T proteins was dependent on androgenic steroid and a functional androgen receptor.

show abstract

Regulation of Tissue Enzymes

Cited by 3 publications

References 102 publications

Androgen Environment and β-Glucuronidase Activity in the Human Kidney

Androgen Environment and β-Glucuronidase Activity in the Human Kidney

Role of the Mouse in the Delineation of the Anabolic‐Androgenic Action of Steroids

New Androgen-Stimulated Proteins in the Kidneys of Female Mice*

Contact Info

Product

Resources

About