Regulation of the skeletal muscle metabolism during hibernation of Jaculus orientalis

Hachimi, Zakia El; Tijane, M'hamed; Boissonnet, Gérard; Benjouad, Abdelaziz; Desmadril, Michel; Yon, Jeannine

doi:10.1016/0305-0491(90)90039-v

Cited by 13 publications

(8 citation statements)

References 14 publications

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“…As a result, adenylate energy charge and AMP, thought to be important in regulation of many metabolic enzymes and signaling pathways including AMP activated protein kinase (AMPK), remain unchanged between torpor and euthermia. In contrast to this pattern, skeletal muscle ATP content has been reported to remain constant between euthermia and hibernation in jerboas (Jaculus orientalis), though AMP content decreases by about 50% (87).…”

Section: Does Energy Metabolism Remain Balanced In Temporal Heterothementioning

confidence: 94%

Metabolic Flexibility: Hibernation, Torpor, and Estivation

Staples

2016

Comprehensive Physiology

134

116

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Many environmental conditions can constrain the ability of animals to obtain sufficient food energy, or transform that food energy into useful chemical forms. To survive extended periods under such conditions animals must suppress metabolic rate to conserve energy, water, or oxygen. Amongst small endotherms, this metabolic suppression is accompanied by and, in some cases, facilitated by a decrease in core body temperature-hibernation or daily torpor-though significant metabolic suppression can be achieved even with only modest cooling. Within some ectotherms, winter metabolic suppression exceeds the passive effects of cooling. During dry seasons, estivating ectotherms can reduce metabolism without changes in body temperature, conserving energy reserves, and reducing gas exchange and its inevitable loss of water vapor. This overview explores the similarities and differences of metabolic suppression among these states within adult animals (excluding developmental diapause), and integrates levels of organization from the whole animal to the genome, where possible. Several similarities among these states are highlighted, including patterns and regulation of metabolic balance, fuel use, and mitochondrial metabolism. Differences among models are also apparent, particularly in whether the metabolic suppression is intrinsic to the tissue or depends on the whole-animal response. While in these hypometabolic states, tissues from many animals are tolerant of hypoxia/anoxia, ischemia/reperfusion, and disuse. These natural models may, therefore, serve as valuable and instructive models for biomedical research.

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Section: Does Energy Metabolism Remain Balanced In Temporal Heterothementioning

confidence: 94%

Metabolic Flexibility: Hibernation, Torpor, and Estivation

Staples

2016

Comprehensive Physiology

134

116

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“…Total CO2 and ATP outputs that are produced under aerobic conditions indicate that glucose makes up ~10% of the metabolic energy usage during ground squirrel hibernation (Galster and Morrison, 1970;Morrison, 1960). Furthermore, evidence that glycolysis still occurs during hibernation is supported by the production of pyruvate and lactate (Galster and Morrison, 1970;Galaster and Morrison, 1975;El Hachimi et al, 1990). During arousal periods, the contribution of carbohydrates is reported to increase as animals rewarm, with glucose oxidation aiding energy production for skeletal muscle shivering thermogenesis (Buck and Barnes, 2000).…”

Section: Supplementary Materialsmentioning

confidence: 99%

Regulation of Lactate Dehydrogenase and Glycerol-3-Phosphate Dehydrogenase in Mammalian Hibernation

Ruberto¹

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Hibernation is a winter survival strategy for many small mammals. Animals sink into deep torpor, body temperature falls to near 0°C and physiological functions are strongly suppressed. Enzymes are the catalysts of metabolic pathways in cells and their appropriate control is critical to hibernation success. This thesis explores the properties and regulation of two key enzymes of carbohydrate metabolism (lactate dehydrogenase, LDH) and lipid metabolism (glycerol-3-phosphate dehydrogenase, G3PDH) purified from liver and skeletal muscle of ground squirrels (Urocitellus richardsonii). The studies showed that changes in pH, temperature, and inhibitors play roles in differentially regulating these enzymes between euthermic and torpid states. Furthermore, reversible protein phosphorylation proved to be a significant regulatory mechanism, producing a reduced activity state of skeletal muscle LDH and increased activity state of G3PDH in both skeletal muscle and liver during torpor. Overall, these studies showed that multiple mechanisms of enzyme regulation, particularly protein phosphorylation, contribute to reorganizing fuel metabolism during hibernation. IV Acknowledgements

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“…Diving mammals experience rapid transitions from apnea to re-oxygenation [19], while hibernating mammals face reduced metabolism and fluctuations in blood flow and oxygen consumption [20–23]. “Metabolic shutdowns” happen also in desert mammals, such as the desert mouse [24] and the jerboa [25]. Evidence for oxidative stress or antioxidant adaptations were indeed found in Spalax [26], diving mammals [19, 27], hibernating mammals [22], and desert mammals [28].…”

Section: Introductionmentioning

confidence: 99%

Adaptive patterns in the p53 protein sequence of the hypoxia- and cancer-tolerant blind mole rat Spalax

et al. 2016

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Background: The subterranean blind mole rat, Spalax (genus Nannospalax) endures extreme hypoxic conditions and fluctuations in oxygen levels that threaten DNA integrity. Nevertheless, Spalax is long-lived, does not develop spontaneous cancer, and exhibits an outstanding resistance to carcinogenesis in vivo, as well as anti-cancer capabilities in vitro. We hypothesized that adaptations to similar extreme environmental conditions involve common mechanisms for overcoming stress-induced DNA damage. Therefore, we aimed to identify shared features among species that are adapted to hypoxic stress in the sequence of the tumor-suppressor protein p53, a master regulator of the DNA-damage response (DDR).

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Regulation of the skeletal muscle metabolism during hibernation of Jaculus orientalis

Cited by 13 publications

References 14 publications

Metabolic Flexibility: Hibernation, Torpor, and Estivation

Metabolic Flexibility: Hibernation, Torpor, and Estivation

Regulation of Lactate Dehydrogenase and Glycerol-3-Phosphate Dehydrogenase in Mammalian Hibernation

Adaptive patterns in the p53 protein sequence of the hypoxia- and cancer-tolerant blind mole rat Spalax

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