Regulation of the parental gene GRM4 by circGrm4 RNA transcript and glutamate-mediated neurovascular toxicity in eyes

Eyob, Wintana; George, Akash K.; Homme, Rubens P.; Stanišić, Dragana; Sandhu, Harpal S.; Tyagi, Suresh C.; Singh, Mahavir

doi:10.1007/s11010-020-03934-0

Cited by 8 publications

(4 citation statements)

References 73 publications

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“…CircRNAs consist of non-coding RNAs of approximately 100 nucleotides [100,142,152,313,316,329,[333][334][335][336]414,419,432,[440][441][442][443][444][445]. First identified as having a circular structure, circRNAs use covalent bonds to maintain a circular nature, contain both cis and trans regulation, oversee the expression of genes through the sponging of miRNAs [335,[446][447][448], and can have value as biomarkers [329,335,429,432,436,449].…”

Section: Non-coding Rnas Micrornas and Circular Rnas In Metabolic Dis...mentioning

confidence: 99%

Cornerstone Cellular Pathways for Metabolic Disorders and Diabetes Mellitus: Non-Coding RNAs, Wnt Signaling, and AMPK

Maiese

2023

Cells

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Metabolic disorders and diabetes (DM) impact more than five hundred million individuals throughout the world and are insidious in onset, chronic in nature, and yield significant disability and death. Current therapies that address nutritional status, weight management, and pharmacological options may delay disability but cannot alter disease course or functional organ loss, such as dementia and degeneration of systemic bodily functions. Underlying these challenges are the onset of aging disorders associated with increased lifespan, telomere dysfunction, and oxidative stress generation that lead to multi-system dysfunction. These significant hurdles point to the urgent need to address underlying disease mechanisms with innovative applications. New treatment strategies involve non-coding RNA pathways with microRNAs (miRNAs) and circular ribonucleic acids (circRNAs), Wnt signaling, and Wnt1 inducible signaling pathway protein 1 (WISP1) that are dependent upon programmed cell death pathways, cellular metabolic pathways with AMP-activated protein kinase (AMPK) and nicotinamide, and growth factor applications. Non-coding RNAs, Wnt signaling, and AMPK are cornerstone mechanisms for overseeing complex metabolic pathways that offer innovative treatment avenues for metabolic disease and DM but will necessitate continued appreciation of the ability of each of these cellular mechanisms to independently and in unison influence clinical outcome.

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Section: Non-coding Rnas Micrornas and Circular Rnas In Metabolic Dis...mentioning

confidence: 99%

Cornerstone Cellular Pathways for Metabolic Disorders and Diabetes Mellitus: Non-Coding RNAs, Wnt Signaling, and AMPK

Maiese

2023

Cells

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“… 169 According to a recent study by Eyob et al, circGRM4 was found to be significantly upregulated in the eyes of cystathionine β-synthase-deficient mice in response to extremely high circulating glutamate concentrations, which can lead to retinal vascular dysfunction. 170 circPSD3 (circRNA Pleckstrin and Sec7 domain-containing 3) acts as a sponge for miR-92b-3p. In vivo overexpression of circPSD3 after injection of AAV8-circPSD3 through the tail vein arrested the deterioration of CCl 4 -induced hepatic fibrosis as indicated by reduced serum ALT and AST content and the degree of hepatic fibrogenesis.…”

Section: Non-coding Rnas In Amino Acid Metabolismmentioning

confidence: 99%

Decoding the regulatory roles of non-coding RNAs in cellular metabolism and disease

Zong¹,

Wang²,

Cheng³

et al. 2023

Molecular Therapy

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“…Increasing potential roles of circRNAs of hosts were reported, and several data showed that virally circRNAs with similar structures might have similar regulatory roles in various biological processes. The mainly reported roles of circRNAs acted as microRNAs (69-71)/RNA binding proteins (37,72,73) sponges, mediated the alternative splicing and transcription process (74)(75)(76), regulated the expression levels of parental genes (77), translated proteins or small peptides (36, 53, 78-80) (Figure 4). circRNA acts on the miRNA sponge, indirectly regulating the mRNA expression level of miRNA target genes and affecting various biological processes.…”

Section: The Potential Roles Of Virally Circrnasmentioning

confidence: 99%

Viral Circular RNAs and Their Possible Roles in Virus-Host Interaction

et al. 2022

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Circular RNAs (circRNAs) as novel regulatory molecules have been recognized in diverse species, including viruses. The virus-derived circRNAs play various roles in the host biological process and the life cycle of the viruses. This review summarized the circRNAs from the DNA and RNA viruses and discussed the biogenesis of viral and host circRNAs, the potential roles of viral circRNAs, and their future perspective. This review will elaborate on new insights gained on viruses encoded circRNAs during virus infection.

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Regulation of the parental gene GRM4 by circGrm4 RNA transcript and glutamate-mediated neurovascular toxicity in eyes

Cited by 8 publications

References 73 publications

Cornerstone Cellular Pathways for Metabolic Disorders and Diabetes Mellitus: Non-Coding RNAs, Wnt Signaling, and AMPK

Cornerstone Cellular Pathways for Metabolic Disorders and Diabetes Mellitus: Non-Coding RNAs, Wnt Signaling, and AMPK

Decoding the regulatory roles of non-coding RNAs in cellular metabolism and disease

Viral Circular RNAs and Their Possible Roles in Virus-Host Interaction

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