Regulation of the Natural Killer Cell Response to Interferon-α by Biogenic Amines

Hellstrand, Kristoffer; Kylefjord, Helen; Asea, Alexzander; Hermodsson, Svante

doi:10.1089/jir.1992.12.199

Cited by 25 publications

(11 citation statements)

References 32 publications

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“…This finding corroborates previous studies showing that superoxide radicals down-regulate most NK cell functions (22,23,(35)(36)(37)(38)(39). NK cells rapidly migrate to extravascular sites to attack and destroy altered target cells (40), and they are therefore especially important in controlling HSV infections in which the virus-infected cells otherwise escape CD8 ϩ T cell-mediated destruction as a consequence of the virus-induced downmodulation of MHC class I expression.…”

Section: Discussionsupporting

confidence: 91%

A Proinflammatory Peptide from Herpes Simplex Virus Type 2 Glycoprotein G Affects Neutrophil, Monocyte, and NK Cell Functions

Bellner

Thorén²,

Nygren

et al. 2005

The Journal of Immunology

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We have identified a synthetic peptide derived from the secreted portion of HSV type 2 glycoprotein G, denoted gG-2p20, which has proinflammatory properties in vitro. The gG-2p20 peptide, corresponding to aa 190–205 of glycoprotein G-2, was a chemoattractant for both monocytes and neutrophils in a dose-dependent fashion, and also induced the release of reactive oxygen from these cells. The receptor mediating the responses was identified as the formyl peptide receptor. The gG-2p20-induced activation of phagocytes had a profound impact on NK cell functions. The reactive oxygen species produced by gG-2p20-activated phagocytes both inhibited NK cell cytotoxicity and accelerated the apoptotic cell death in NK cell-enriched lymphocyte populations. Hence, we have for the first time been able to identify a potential function of the secreted portion of HSV-2 glycoprotein G. We propose that the proinflammatory gG-2p20 peptide identified could contribute to a reduced function and viability of NK cells during HSV-2 infection due to its ability to recruit and activate phagocytic cells.

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Section: Discussionsupporting

confidence: 91%

A Proinflammatory Peptide from Herpes Simplex Virus Type 2 Glycoprotein G Affects Neutrophil, Monocyte, and NK Cell Functions

Bellner

Thorén²,

Nygren

et al. 2005

The Journal of Immunology

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“…In the presence of superoxide, released by macrophages, hypochlorous acid generates hydroxl radicals (29), which react with most biological molecules, creating secondary radicals of variable reactivity. There is evidence that production of oxygen radicals by monocytes inhibits the natural killer cell immune response (52). If so, higher expression of the MPO enzyme by leukemic cells carrying the AML allele might enable those cells to preferentially escape immune surveillance, which could explain why fewer AML patients carry the MPO allele.…”

Section: Discussionmentioning

confidence: 99%

An Alu Element in the Myeloperoxidase Promoter Contains a Composite SP1-Thyroid Hormone-Retinoic Acid Response Element

Piedrafita

Molander

Vansant

et al. 1996

Journal of Biological Chemistry

382

255

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“…This is suggested by the fact that agents such as histamine, serotonin, prostaglandin, and heparin glycosaminoglycan have been shown to pro duce immunoregulatory effects. For example, both hista mine and serotonin can regulate natural killer cell responses to IFN-« by bioaminergic receptors [7]. Also, serotonin has been shown to augment IFN-y-induced phagocytosis [8], suppress IFN-y-induced la expression by murine macro phages [9], augment NK cell cytotoxicity [10], and to sup press mitogen-stimulated T cell proliferation [11], Based upon this kind of evidence described above and the knowledge that histamine and serotonin are preformed substances readily available from mast cells and platelets which are both closely associated with blood vessels, it was of interest in this study to examine the influence of these amines on the biosynthesis and surface membrane expres sion o f MHC class II and adhesion molecules.…”

Section: Introductionmentioning

confidence: 99%

Differing Regulation of Major Histocompatibility; Class II and Adhesion Molecules on Human Umbilical Vein Endothelial Cells by Serotonin

Li¹,

Joshua

Lian³

et al. 1997

Int Arch Allergy Immunol

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Major histocompatibility class II molecules (MHC class II), whose biosynthesis and expression by endothelial cells can be induced by Γ-interferon (IFN-Γ), play a major role in antigen recognition and subsequent cell-cell interactions involved in the initiation of immune responses. Adhesion molecules such as E-selectin and intercellular adhesion molecules (ICAM-1), whose biosynthesis and membrane expression by endothelial cells is regulated by proinflammatory cytokines (IL-1 and TNF), are necessary for the attachment and subsequent extravasation of leukocytes into the surrounding tissue. In the present study, the effects of preformed inflammatory mediators (histamine and serotonin) on the induction and expression of MHC class II, E-selectin, and ICAM-1 molecules by human umbilical vein endothelial cells were examined. Serotonin but not histamine was found to significantly inhibit in a dose-response fashion the induction and expression of MHC class II molecules. Inhibition occurred when it was added 24 h before, at the same time (most effective), or 24 h after IFN-Γ stimulation. No enhancement or stimulation of MHC class II biosynthesis could be detected using moderate or low concentration of either histamine or serotonin alone. In contrast to MHC class II molecules, neither serotonin nor histamine blocked the induction and biosynthesis of E-selectin and ICAM-1 molecules as detected by specific HI 8/7 and RR1/1 monoclonal antibodies, respectively, using flow cytometry. These findings suggest that serotonin but not histamine can assist in regulating the induction and expression of MHC class II molecules. Failure to block biosynthesis of E-selectin and ICAM-1 induced by TNF-Α and IL-1Β indicates the inhibitory effect exerted by serotonin was selective in nature.

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Regulation of the Natural Killer Cell Response to Interferon-α by Biogenic Amines

Cited by 25 publications

References 32 publications

A Proinflammatory Peptide from Herpes Simplex Virus Type 2 Glycoprotein G Affects Neutrophil, Monocyte, and NK Cell Functions

A Proinflammatory Peptide from Herpes Simplex Virus Type 2 Glycoprotein G Affects Neutrophil, Monocyte, and NK Cell Functions

An Alu Element in the Myeloperoxidase Promoter Contains a Composite SP1-Thyroid Hormone-Retinoic Acid Response Element

Differing Regulation of Major Histocompatibility; Class II and Adhesion Molecules on Human Umbilical Vein Endothelial Cells by Serotonin

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