Regulation of the metabolism of vitamin D.

Fraser, Donald R.

doi:10.1152/physrev.1980.60.2.551

Cited by 329 publications

(142 citation statements)

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“…In Shenyang, women tend to be involved in more outdoor activities, such as shopping in the open market, looking after children and talking with neighbours in the yard, Figure 1 25(OH)D and PTH in old subjects (Prentice et al, 1998). Low intakes of calcium or phosphate have been reported to increase the production of 1,25(OH) 2 D in some studies (Bouillon et al, 1995;Fraser, 1980;Kumar, 1986). Therefore, the results in Shenyang may be due to an adaptation of 1,25(OH) 2 D production to low calcium intakes.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D status and parathyroid hormone concentrations in Chinese women and men from north-east of the People’s Republic of China

et al. 2000

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D) and PTH using radioimmunoassays. The proportion of subjects who could be regarded as vitamin D de®cient (`25 nmolal) was 48%, 29%, 15% and 13% for old men, young men, old women and young women, respectively. There was no association between plasma 1,25(OH) 2 D and 25(OH)D concentrations. PTH concentrations were elevated in both old women and men compared with young subjects (P`0.01). A negative association between PTH and 25(OH)D was only found in old women (P`0.001), but not in old men, nor in young subjects. Conclusions: Vitamin D status was poor in this population in early spring, especially in men. There was no clear evidence to show that the secretion of PTH and the conversion of 1,25(OH) 2 D were affected by the low 25(OH)D concentration.

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Section: Discussionmentioning

confidence: 99%

Vitamin D status and parathyroid hormone concentrations in Chinese women and men from north-east of the People’s Republic of China

et al. 2000

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“…The main function of vitamin D is to enhance intestinal absorption of calcium (Ca) and phophorus (P) (reviews 12,15). This effect, however, is first achieved after a series of metabolic alterations.…”

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Plasma Concentrations of Vitamin D Metabolites in Premature Infants

et al. 1984

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“…The main regulator is parathyroid hormone (PTH), which increases the formation of 1,25(OH) 2 D as a response to low serum calcium levels. The formation of 1,25(OH) 2 D is also affected by serum phosphate where elevated phosphate levels have an inhibitory effect (Fraser, 1980). In the circulation, both 25(OH)D and 1,25(OH) 2 D are bound to plasma proteins, and less than 1% circulate in free form.…”

Section: Introductionmentioning

confidence: 99%

Associations between Polymorphisms Related to Calcium Metabolism and Human Height: The Tromsø Study

Jorde

Svartberg

Joakimsen

et al. 2012

Annals of Human Genetics

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SummaryA number of single nucleotide polymorphisms (SNPs) related to height have been detected. Calcium metabolism is important for the skeleton and accordingly also for adult height. Therefore, in the present study, nine SNPs related to the vitamin D receptor (VDR) gene and serum levels of 25-hydroxyvitamin D (25(OH)D), calcium, phosphate and parathyroid hormone (PTH) were related to height in 9471 subjects. Relation with height was evaluated with linear regression for trend across SNP genotypes with age and gender as covariates. After correcting for multiple testing, significant associations with height were found for two SNPs related to the VDR gene (rs1544410 (Bsml) and rs7975232 (Apal)), one SNP related to serum 25(OH)D (rs3829251 at the DHCR7/NADSYN1 gene), one SNP related to serum calcium (rs1459015 at the PTH gene) and one SNP related to serum phosphate (rs1697421 at the ALPL gene). For rs3829251, the mean differences in height between major and minor homozygotes were 1.5-2.0 cm (P < 0.01) and were seen in both genders and all age groups tested, whereas for the other SNPs, the differences were less than 1 cm. In conclusion, several SNPs related to calcium metabolism are associated with height, in particular rs3829251 at the DHCR7/NADSYN1 gene.

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Regulation of the metabolism of vitamin D.

Cited by 329 publications

References 0 publications

Vitamin D status and parathyroid hormone concentrations in Chinese women and men from north-east of the People’s Republic of China

Vitamin D status and parathyroid hormone concentrations in Chinese women and men from north-east of the People’s Republic of China

Plasma Concentrations of Vitamin D Metabolites in Premature Infants

Associations between Polymorphisms Related to Calcium Metabolism and Human Height: The Tromsø Study

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