Regulation of the intestinal flora: A potential mechanism of natural medicines in the treatment of type 2 diabetes mellitus

He, Lin; Yang, Fangqing; Tang, Pan; Gao, Tinghui; Yang, Caixia; Tan, Li; Pan, Y.; Hua, Yanan; Liu, Sijing; Guo, Jiao

doi:10.1016/j.biopha.2022.113091

Cited by 15 publications

(8 citation statements)

References 151 publications

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“…A growing number of evidences have proven that the gut microbiota compositions in lean and obese populations are significantly different (Tsukumo, Carvalho, Carvalho & Saad, 2015). The changes in gut microbiota composition and structure, such as the Firmicutes/Bacteroides ratio alteration, could affect intestinal function, host metabolism and signal transduction pathways, resulting in obesity, IR and eventually diabetes (He et al, 2022;Xie, Zhao & Chen, 2021).…”

Section: Reversinggut Microbiota Dysbiosismentioning

confidence: 99%

New insights of active constituents from herbs and nutraceuticals and their mechanisms in obesity-induced insulin resistance

Lin

et al. 2023

Preprint

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Insulin resistance (IR) is a main etiology of various metabolic diseases such as type 2 diabetes mellitus (T2DM), hypertension, hyperlipidemia and coronary heart disease. IR is a multi-factorial etiology disease regulated by various mechanisms. Obesity, a significant public health problem worldwide, is considered as a high-risk factor to induce IR and T2DM. Thus, inhibiting obesity-induced IR is one of the key therapeutic strategies to improve T2DM. Natural products from herbs and nutraceuticals have shown promising efficacy on obesity-induced IR and T2DM owing to its multi-component and multi-target characteristics. However, the active constituents and the action mechanisms are still not yet well elucidated. In this review, the natural constituents with protective capacities against IR were summarized. The active constituents include crude extracts such as polyphenols, saponins, alkaloids, terpenoids, phenylpropanoids, as well as monomeric compounds such as curcumin, berberine, capsaicin, naringenin, quercetin, betaine and isoliquiritigenin. The action mechanisms of these active constituents could be mainly divided into 4 categories: ameliorating metabolic abnormality, inhibiting inflammation, reversing gut microbiota dysbiosis, regulating micro RNAs (miRNAs). Their precise roles in regulating PI3K/AKT, AMPK, PPARs, SIRT1 and NF-κB pathways, brown adipose tissue activity and white adipose tissue browning, NLRP3 inflammasome activity, gut microbiota structure and composition and miRNA expression were discussed. The sources, chemical structures, experimental models, pharmacological effects and action targets of these active constituents were also summarized. This review provides new active constituents, therapeutic targets and reasoning for the clinical application of herbs and nutraceuticals in the treatment of IR and T2DM.

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Section: Reversinggut Microbiota Dysbiosismentioning

confidence: 99%

New insights of active constituents from herbs and nutraceuticals and their mechanisms in obesity-induced insulin resistance

Lin

et al. 2023

Preprint

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“…Type 1 is caused by insufficient insulin production due to the destruction of beta cells in the pancreas. Type 2 diabetes, on the other hand, begins with insulin resistance, which is the insufficiency of insulin secretion in the body and the inability of cells to respond to insulin correctly [ 66 , 67 ].…”

Section: Introductionmentioning

confidence: 99%

“…Approximately 90% of cases of diabetes, which is seen in very high numbers worldwide and is the sixth highest cause of death, have been determined to be Type 2 diabetes. On the other hand, in addition to reducing quality of life, diabetes has been reported to be a precursor to severe disorders, such as cardiovascular diseases, kidney diseases, cancer, and foot ulcers [ 67 ]. Therefore, the treatment of diabetes has gained even more importance.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Potential Medicinal Benefits of Ganoderma lucidum: From Metabolic Disorders to Coronavirus Infections

Ekiz

Öz

El‐Aty

et al. 2023

Foods

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Ganoderma lucidum is a medicinal mushroom that has been traditionally used in Chinese medicine for centuries. It has been found to have a wide range of medicinal properties, including antioxidant, anti-inflammatory, and immune-boosting effects. Recent research has focused on the potential benefits of G. lucidum in treating metabolic disorders such as diabetes and obesity, as well as its possible role in preventing and treating infections caused by the coronavirus. Triterpenoids are a major group of bioactive compounds found in G. lucidum, and they have a range of biological activities, including anti-inflammatory and antioxidant properties. These compounds have been found to improve insulin sensitivity and lower blood sugar levels in animal models of diabetes. Additionally, G. lucidum polysaccharides have been found to reduce bodyweight and improve glucose metabolism in animal models of obesity. These polysaccharides can also help to increase the activity of certain white blood cells, which play a critical role in the body’s immune response. For coronavirus, some in vitro studies have shown that G. lucidum polysaccharides and triterpenoids have the potential to inhibit coronavirus infection; however, these results have not been validated through clinical trials. Therefore, it would be premature to draw any definitive conclusions about the effectiveness of G. lucidum in preventing or treating coronavirus infections in humans.

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“…1 Type 2 diabetes (T2D) is a metabolic syndrome characterized by hyperglycemia, hyperlipidemia, and insulin resistance, accounting for more than 90% of patients with diabetes. 2,3 Importantly, T2D is also a predisposing factor for developing various diseases, including neuropathy and cardiovascular and liver diseases. 4 The liver, a vital organ for lipid and glucose metabolism and maintaining homeostasis in the body, was abnormal in over 50% of patients with T2D, who may experience accelerated progression of hepatitis, cirrhosis, and even hepatic cancer.…”

Section: Introductionmentioning

confidence: 99%

“…The number of patients with diabetes worldwide is expected to reach 700 million in the next 20 years 1 . Type 2 diabetes (T2D) is a metabolic syndrome characterized by hyperglycemia, hyperlipidemia, and insulin resistance, accounting for more than 90% of patients with diabetes 2,3 . Importantly, T2D is also a predisposing factor for developing various diseases, including neuropathy and cardiovascular and liver diseases 4 .…”

Section: Introductionmentioning

confidence: 99%

Metabolomics reveals the role of Lactobacillus plantarumSHY130 in hepatic metabolic regulation in a mouse model of type 2 diabetes

Wang,

Song,

Wang

et al. 2023

J Sci Food Agric

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BACKGROUNDAmong type 2 diabetes (T2D) patients, the incidence rate of liver metabolic disorders is much higher than that in healthy subjects. It was observed in our previous research that diabetic symptoms were improved by Lactobacillus plantarum SHY130 (LPSHY130) isolated from yak yogurt in a murine model of T2D. This study sought to investigate the LPSHY130‐mediated hepatic metabolic regulation in a murine model of T2D.RESULTSTreatment with LPSHY130 improved liver function and pathological damage in diabetic mice. Untargeted metabolome analysis revealed that T2D‐induced changes in 11 metabolites were regulated after LPSHY130 treatment, mainly involving purine metabolism, amino acid metabolism, and choline metabolism and pantothenate and coenzyme A biosynthesis pathways. In addition, correlation analysis indicated that hepatic metabolic changes can be adjusted by the intestinal microbiota.CONCLUSIONOverall, this study suggests that treatment with LPSHY130 relieves liver injury and regulates liver metabolism in a murine model of T2D, thus providing a theoretical basis for the use of probiotics as dietary supplements to regulate hepatic metabolic disorders associated with T2D. © 2023 Society of Chemical Industry.

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Regulation of the intestinal flora: A potential mechanism of natural medicines in the treatment of type 2 diabetes mellitus

Cited by 15 publications

References 151 publications

New insights of active constituents from herbs and nutraceuticals and their mechanisms in obesity-induced insulin resistance

New insights of active constituents from herbs and nutraceuticals and their mechanisms in obesity-induced insulin resistance

Exploring the Potential Medicinal Benefits of Ganoderma lucidum: From Metabolic Disorders to Coronavirus Infections

Metabolomics reveals the role of Lactobacillus plantarumSHY130 in hepatic metabolic regulation in a mouse model of type 2 diabetes

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