Regulation of the fate of human mesenchymal stem cells by mechanical and stereo-topographical cues provided by silicon nanowires

Kuo, Shi‐Wen; Lin, Hsin I.; Ho, Jennifer H.; Shih, Yu Ru V.; Chen, How Foo; Yen, Ta‐Jen; Lee, Oscar K.

doi:10.1016/j.biomaterials.2012.03.080

Cited by 102 publications

(130 citation statements)

References 47 publications

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“…Interactions between normal or stem cells and silicon NWs have been the focus of recent studies (Zhang et al 2012;Julien et al 2010), and there has been success in regulating the osteogenic differentiation of stem cells when grown on Si NWs matrices of different lengths (Kuo et al 2012). In the context of magnetic materials, the biocompatibility of iron NWs has also been validated for the application of cell manipulation (Song et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity and intracellular dissolution of nickel nanowires

Perez

Contreras²,

Vilanova

et al. 2016

Nanotoxicology

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The assessment of cytotoxicity of nanostructures is a fundamental step for their development as biomedical tools. As widely used nanostructures, nickel nanowires (Ni NWs) seem promising candidates for such applications. In this work, Ni NWs were synthesized and then characterized using vibrating sample magnetometry, energy dispersive X-Ray analysis and electron microscopy. After exposure to the NWs, cytotoxicity was evaluated in terms of cell viability, cell membrane damage and induced apoptosis/necrosis on the model human cell line HCT 116. The influence of NW to cell ratio (10:1 to 1000:1) and exposure times up to 72 hours was analyzed for Ni NWs of 5.4 µm in length, as well as for Ni ions. The results show that cytotoxicity markedly increases past 24 hours of incubation. Cellular uptake of NWs takes place through the phagocytosis pathway, with a fraction of the dose of NWs dissolved inside the cells. Cell death results from a combination of apoptosis and necrosis, where the latter is the outcome of the secondary necrosis pathway. The cytotoxicity of Ni ions and Ni NWs dissolution studies suggest a synergistic toxicity between NW aspect ratio and dissolved Ni, with the cytotoxic effects markedly increasing after 24 hours of incubation.Just Accepted by Nanotoxicology © 2015 Taylor & Francis. This provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon.DISCLAIMER: The ideas and opinions expressed in the journal's Just Accepted articles do not necessarily reflect those of Taylor & Francis (the Publisher), the Editors or the journal. The Publisher does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of the material contained in these articles. The reader is advised to check the appropriate medical literature and the product information currently provided by the manufacturer of each drug to be administered to verify the dosages, the method and duration of administration, and contraindications. It is the responsibility of the treating physician or other health care professional, relying on his or her independent experience and knowledge of the patient, to determine drug dosages and the best treatment for the patient. Just Accepted articles have undergone full scientific review but none of the additional editorial preparation, such as copyediting, typesetting, and proofreading, as have articles published in the traditional manner. There may, therefore, be errors in Just Accepted articles that will be corrected in the final print and final online version of the article. Any use of the Just Accepted articles is subject to the express understanding that the papers have not yet gone through the full quality control process prior to publication. Cytotoxicity and intracellular dissolution of nickel nanowiresJose E. Perez 1, 2 , Maria F. Contreras 1 , Enrique Vilanova 2 , Laura P. Felix 1, 2 , Michael B.

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Section: Introductionmentioning

confidence: 99%

Cytotoxicity and intracellular dissolution of nickel nanowires

Perez

Contreras²,

Vilanova

et al. 2016

Nanotoxicology

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“…26,[31][32][33][34][35] Second, cell proliferation/adhesion are not seriously affected by surficial compositions, other than surficial topographies. [67][68][69] In addition, histological inflammation and infection do not easily occur with sterilized extraneous objects without the involvement of germs, viruses, or macroscopic stabs.…”

Section: Apl Mater 5 074102 (2017)mentioning

confidence: 99%

Comprehensive biocompatibility of nontoxic and high-output flexible energy harvester using lead-free piezoceramic thin film

et al. 2017

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Flexible piezoelectric energy harvesters have been regarded as an overarching candidate for achieving self-powered electronic systems for environmental sensors and biomedical devices using the self-sufficient electrical energy. In this research, we realize a flexible high-output and lead-free piezoelectric energy harvester by using the aerosol deposition method and the laser lift-off process. We also investigated the comprehensive biocompatibility of the lead-free piezoceramic device using ex-vivo ionic elusion and in vivo bioimplantation, as well as in vitro cell proliferation and histologic inspection. The fabricated LiNbO3-doped (K,Na)NbO3 (KNN) thin film-based flexible energy harvester exhibited an outstanding piezoresponse, and average output performance of an open-circuit voltage of ∼130 V and a short-circuit current of ∼1.3 μA under normal bending and release deformation, which is the best record among previously reported flexible lead-free piezoelectric energy harvesters. Although both the KNN and Pb(Zr,Ti)O3 (PZT) devices showed short-term biocompatibility in cellular and histological studies, excessive Pb toxic ions were eluted from the PZT in human serum and tap water. Moreover, the KNN-based flexible energy harvester was implanted into a porcine chest and generated up to ∼5 V and 700 nA from the heartbeat motion, comparable to the output of previously reported lead-based flexible energy harvesters. This work can compellingly serve to advance the development of piezoelectric energy harvesting for actual and practical biocompatible self-powered biomedical applications beyond restrictions of lead-based materials in long-term physiological and clinical aspects.

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“…Stem cells cultured on nanofiber scaffolds exhibit high viability and lower mobility, and differ in morphology when compared with cells cultured on conventional substrates (e.g., polystyrene) [102,103]. Nanofibers with a controlled diameter (e.g., 300-1000 nm) are composed of either natural polymers, such as collagen and silk, or synthetic polymers including poly(lactic acid) and poly(amide) [102,104,105]. The 3D organization, surface and chemistry of these scaffolds result in stem cell self-renewal, migration and differentiation.…”

Section: A U T H O R P R O O Fmentioning

confidence: 99%

Nanodentistry: Combining Nanostructured Materials and Stem Cells for Dental Tissue Regeneration

2012

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Regenerative dentistry represents an attractive multidisciplinary therapeutic approach that complements traditional restorative/surgery techniques and benefits from recent advances in stem cell biology, molecular biology, genomics and proteomics. Materials science is important in such advances to move regenerative dentistry from the laboratory to the clinic. The design of novel nanostructured materials, such as biomimetic matrices and scaffolds for controlling cell fate and differentiation, and nanoparticles for diagnostics, imaging and targeted treatment, is needed. The combination of nanotechnology, which allows the creation of sophisticated materials with exquisite fine structural detail, and stem cell biology turns out to be increasingly useful in regenerative medicine. The administration to patients of dynamic biological agents comprising stem cells, bioactive scaffolds and/or nanoparticles will certainly increase the regenerative impact of dental pathological tissues. This overview briefly describes some of the actual benefits and future possibilities of nanomaterials in the emerging field of stem cell-based regenerative dentistry.

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Regulation of the fate of human mesenchymal stem cells by mechanical and stereo-topographical cues provided by silicon nanowires

Cited by 102 publications

References 47 publications

Cytotoxicity and intracellular dissolution of nickel nanowires

Cytotoxicity and intracellular dissolution of nickel nanowires

Comprehensive biocompatibility of nontoxic and high-output flexible energy harvester using lead-free piezoceramic thin film

Nanodentistry: Combining Nanostructured Materials and Stem Cells for Dental Tissue Regeneration

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