Regulation of the content of progesterone and estrogen receptors, and their cofactors SRC-1 and SMRT by the 26S proteasome in the rat brain during the estrous cycle

Villamar-Cruz, Olga; Manjarrez-Marmolejo, Joaquín; Alvarado, Raúl

doi:10.1016/j.brainresbull.2005.12.006

Cited by 20 publications

(14 citation statements)

References 35 publications

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“…SRC-1 is degraded through ubiquitin-26S proteasome, since in the presence of 26S proteasome inhibitor MG132, SRC-1 content was at higher steady state level [52], and under physiological conditions the content of SRC-1 was significantly increased after MG132 injection into the rat brain [7], it is possible that P 4 could induce SRC-1 phosphorylation with the subsequent signalling to its degradation by 26S proteasome.…”

Section: Discussionmentioning

confidence: 99%

“…Progesterone (P 4 ) and estradiol (E 2 ) regulate several functions through the interaction with their nuclear receptors (PR and ER, respectively) [5][6][7] which have been detected in several human brain tumors such as astrocytomas, meningiomas, chordomas, and craniopharyngiomas [8][9][10][11][12][13]. In astrocytomas, a direct relation between the content of PR and the tumor grade has been reported, suggesting that PR-positive tumors possess a high proliferative potential, whereas ER expression is inversely related to astrocytoma grade [8,9,[14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Progesterone and estradiol effects on SRC-1 and SRC-3 expression in human astrocytoma cell lines

Hernández-Hernández

Rodríguez-Dorantes

González-Arenas

2009

Endocr

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Progesterone (P(4)) and estradiol (E(2)) regulate many cell functions through their interaction with specific intracellular receptors, which require the participation of coactivators such as SRC-1 and SRC-3 for enhancing their transcriptional activity. Coactivator expression is altered in many cancers and in some of them their expression is regulated by P(4) and E(2). In this study, we determined progesterone and estrogen receptor isoform expression in two human astrocytoma cell lines with different evolution grade (U373, grade III; and D54, grade IV) by Western Blot. We studied the role of P(4) and E(2) on SRC-1 and SRC-3 expression in U373 and D54 cell lines by RT-PCR and Western blot. In U373 cells, P(4) did not modify SRC-1 expression, but in D54 cells it increased SRC-1 mRNA expression after 12 h of treatment without significant changes after 24 h. P(4) also increased SRC-1 protein content after 24 h, but reduced it after 48 h. E(2) did not change SRC-1 expression in any cell line. SRC-3 expression was not regulated by either E(2) or P(4). Our data suggest that SRC-1 and SRC-3 expression is differentially regulated by sex steroid hormones in astrocytomas and that P(4) regulates SRC-1 expression depending on the evolution grade of human astrocytoma cells.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Progesterone and estradiol effects on SRC-1 and SRC-3 expression in human astrocytoma cell lines

Hernández-Hernández

Rodríguez-Dorantes

González-Arenas

2009

Endocr

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“…Progesterone regulates several functions through the interaction with its nuclear receptors [4][5][6]. Two PR isoforms have been reported: a full-length form (PR-B, 114 kDa) and an N-terminal truncated one (PR-A, 94 kDa) which are functionally different [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Regulation of progesterone receptor isoforms content in human astrocytoma cell lines

Cabrera-Muñoz

González-Arenas

Saqui‐Salces

et al. 2009

The Journal of Steroid Biochemistry and Molecular Biology

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“…Treatment with a 26S proteasome inhibitor increases SRC-1 expression in the hypothalamus, POA and hippocampus (Villamar-Cruz et al, 2006). In addition, this same treatment up-regulated PR and ERβ in the same brain regions, while ERα was increased only in the POA.…”

Section: Function Of Nuclear Receptor Coactivators In the Central Nermentioning

confidence: 99%

Modulation of steroid action in the central and peripheral nervous systems by nuclear receptor coactivators

Tetel

2009

Psychoneuroendocrinology

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Steroid hormones act in the central and peripheral nervous systems to regulate a variety of functions, including development, cell proliferation, cognition and behavior. Many of these effects of steroid hormones are mediated by their respective receptors, which are members of the nuclear receptor superfamily of transcriptional activators. A variety of cell culture studies reveal that nuclear receptor coactivators are recruited to the steroid receptor complex and are critical in modulating steroiddependent transcription. Thus, in addition to the availability of the hormone and its receptor, the expression of nuclear receptor coactivators is essential for modulating steroid receptor mediated transcription. This review will discuss the significance of nuclear receptor coactivators in modulating steroid-dependent gene expression in the central and peripheral nervous systems and the regulation of behavior.

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Regulation of the content of progesterone and estrogen receptors, and their cofactors SRC-1 and SMRT by the 26S proteasome in the rat brain during the estrous cycle

Cited by 20 publications

References 35 publications

Progesterone and estradiol effects on SRC-1 and SRC-3 expression in human astrocytoma cell lines

Progesterone and estradiol effects on SRC-1 and SRC-3 expression in human astrocytoma cell lines

Regulation of progesterone receptor isoforms content in human astrocytoma cell lines

Modulation of steroid action in the central and peripheral nervous systems by nuclear receptor coactivators

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