Regulation of testicular function by cell‐to‐cell interaction

Fujisawa, Masato

doi:10.1111/j.1447-0578.2006.00118.x

Cited by 7 publications

(7 citation statements)

References 67 publications

(67 reference statements)

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“…The cumulative number of Sertoli cell is positively correlated with testicular size and sperm count ( 94 ). Tissue transformation that takes place during spermiation is achieved through the activities of proteases produced by Sertoli cells ( 21 ). Similarly, plasminogen activator which facilitates the migration of preleptotene spermatocytes are produced by Sertoli cells ( 21 ).…”

Section: Bisphenols Sertoli Cells and Male Reproductive Healthmentioning

confidence: 99%

“…Tissue transformation that takes place during spermiation is achieved through the activities of proteases produced by Sertoli cells ( 21 ). Similarly, plasminogen activator which facilitates the migration of preleptotene spermatocytes are produced by Sertoli cells ( 21 ). Importantly, Sertoli cells expansive junctional networks and communication provide structural support for developing germ cells ( 20 ).…”

Section: Bisphenols Sertoli Cells and Male Reproductive Healthmentioning

confidence: 99%

“…Once BPA and analogs are absorbed into the body, their major targets include testicular cells ( 19 , 20 ). Functional cells of the testes include Leydig, Sertoli, and germ cells ( 21 ). Although the testis houses other important cells such as peritubular myoid, nerve, blood, and lymphatic endothelial cells, information on impact of bisphenols on these cells in relation to male reproductive health is few ( 22 ).…”

Section: Introductionmentioning

confidence: 99%

“…Although the testis houses other important cells such as peritubular myoid, nerve, blood, and lymphatic endothelial cells, information on impact of bisphenols on these cells in relation to male reproductive health is few ( 22 ). Leydig cells produce testosterone, which perform a crucial function in differentiation of the germ cells and maintenance of testicular functions ( 21 ). Additionally, testosterone produced by Leydig cells perform important functions in the maintenance of the prostate gland ( 23 ).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, Sertoli cells secrete lactate and pyruvate, which are sources of energy for germ cells ( 26 – 29 ). Their number in the testes is, therefore, closely related to testicular volume and sperm yield ( 21 ). The production of viable spermatozoa involves a sequence of gradual differentiation of germ cells via mitosis and meiosis, and final transformation into mature sperm ( 30 , 31 ).…”

Section: Introductionmentioning

confidence: 99%

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Bisphenols Threaten Male Reproductive Health via Testicular Cells

2020

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Male reproductive function and health are largely dependent on the testes, which are strictly regulated by their major cell components, i. e., Sertoli, Leydig, and germ cells. Sertoli cells perform a crucial phagocytic function in addition to supporting the development of germ cells. Leydig cells produce hormones essential for male reproductive function, and germ cell quality is a key parameter for male fertility assessment. However, these cells have been identified as primary targets of endocrine disruptors, including bisphenols. Bisphenols are a category of man-made organic chemicals used to manufacture plastics, epoxy resins, and personal care products such as lipsticks, face makeup, and nail lacquers. Despite long-term uncertainty regarding their safety, bisphenols are still being used worldwide, especially bisphenol A. While considerable attention has been paid to the effects of bisphenols on health, current bisphenol-related reproductive health cases indicate that greater attention should be given to these chemicals. Bisphenols, especially bisphenol A, F, and S, have been reported to elicit various effects on testicular cells, including apoptosis, DNA damage, disruption of intercommunication among cells, mitochondrial damage, disruption of tight junctions, and arrest of proliferation, which threaten male reproductive health. In addition, bisphenols are xenoestrogens, which alter organs and cells functions via agonistic or antagonistic interplay with hormone receptors. In this review, we provide in utero, in vivo, and in vitro evidence that currently available brands of bisphenols impair male reproductive health through their action on testicular cells.

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Section: Bisphenols Sertoli Cells and Male Reproductive Healthmentioning

confidence: 99%