Regulation of T cell differentiation and function by epigenetic modification enzymes

Liu, Huicheng; Li, Pingfei; Wei, Zhengping; Zhang, Cai; Xia, Minghui; Du, Qiuyang; Chen, Yufei; Liu, Na; Li, Hua-Bin; Yang, Xun

doi:10.1007/s00281-019-00731-w

Cited by 22 publications

(20 citation statements)

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“…Lysine can accept up to three methyl groups, being mono-, di- or trimethylated. Arginine can be mono- or dimethylated (105). These modifications are involved in the activation or repression of the transcription of genes that they are associated with.…”

Section: Trained Immunity As a Consequence Of Bcg Vaccinationmentioning

confidence: 99%

“…These modifications are involved in the activation or repression of the transcription of genes that they are associated with. While methylation of lysine 4 in histone 3 (H3K4), H3K36, and H3K79 are usually associated with transcription activation; methylation in H3K9, H3K27, and H4K20 are associated with gene silencing (105).…”

Section: Trained Immunity As a Consequence Of Bcg Vaccinationmentioning

confidence: 99%

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BCG-Induced Cross-Protection and Development of Trained Immunity: Implication for Vaccine Design

et al. 2019

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The Bacillus Calmette-Guérin (BCG) is a live attenuated tuberculosis vaccine that has the ability to induce non-specific cross-protection against pathogens that might be unrelated to the target disease. Vaccination with BCG reduces mortality in newborns and induces an improved innate immune response against microorganisms other than Mycobacterium tuberculosis, such as Candida albicans and Staphylococcus aureus. Innate immune cells, including monocytes and natural killer (NK) cells, contribute to this non-specific immune protection in a way that is independent of memory T or B cells. This phenomenon associated with a memory-like response in innate immune cells is known as “trained immunity.” Epigenetic reprogramming through histone modification in the regulatory elements of particular genes has been reported as one of the mechanisms associated with the induction of trained immunity in both, humans and mice. Indeed, it has been shown that BCG vaccination induces changes in the methylation pattern of histones associated with specific genes in circulating monocytes leading to a “trained” state. Importantly, these modifications can lead to the expression and/or repression of genes that are related to increased protection against secondary infections after vaccination, with improved pathogen recognition and faster inflammatory responses. In this review, we discuss BCG-induced cross-protection and acquisition of trained immunity and potential heterologous effects of recombinant BCG vaccines.

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Section: Trained Immunity As a Consequence Of Bcg Vaccinationmentioning

confidence: 99%

Section: Trained Immunity As a Consequence Of Bcg Vaccinationmentioning

confidence: 99%

BCG-Induced Cross-Protection and Development of Trained Immunity: Implication for Vaccine Design

et al. 2019

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“…Histones methylation may take place at arginine or lysine residues. Upto three methyl groups can be added to lysine residue and upto two methyl groups can be added to the arginine residues [35] .…”

Section: Mechanism Underlying Heterologous Effects Of Bcgmentioning

confidence: 99%

“…Acquisition of histone 3 methylation of lysine 4, lysine 36 and lysine 79 (H3K4, H3K36 and H3K79) are often associated with the transcriptional activation whereas H3K9, H3K27 and H4K20 methylations are involved in repression of gene expression [35] . BCG vaccination upregulates the expression of IL-6, TNF-α, IL-1β and TLR4 in circulating monocytes in nucleotide-binding oligomerization domain 2 (NOD2) dependent manner through an increase in the H3K4me3 histone modification [29] , [36] .…”

Section: Mechanism Underlying Heterologous Effects Of Bcgmentioning

confidence: 99%

New disease old vaccine: Is recombinant BCG vaccine an answer for COVID-19?

Gupta

2020

Cellular Immunology

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Highlights COVID-19, the global pandemic has infected more than 12.8 million people causing pproximtely 5.7 lac deaths worldwide. Fever, dry cough, breathing difficulties (dyspnoea), headache and pneumonia are the common symptoms. Tuberculosis vaccine BCG exhibits beneficial heterologous effects. Recombinant BCG vaccine expressing S protein may be a potential vaccine candidate against COVID-19.

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“…Functionally, we are beginning to understand the importance of epigenetic regulation such as histone modification and DNA methylation in the appropriate differentiation, activation, and maintenance of helper T cells [13]. Liu et al reviewed the dysregulation of epigenetic modification in CD4 + T cells, which are closely related to autoimmune diseases [14]. Kurachi et al also discussed the epigenetic regulation of T cells, especially CD8 + T cells [15].…”

mentioning

confidence: 99%

Pathogenicity of acquired immunity in human diseases

Hirahara

2019

Semin Immunopathol

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Regulation of T cell differentiation and function by epigenetic modification enzymes

Cited by 22 publications

References 100 publications

BCG-Induced Cross-Protection and Development of Trained Immunity: Implication for Vaccine Design

BCG-Induced Cross-Protection and Development of Trained Immunity: Implication for Vaccine Design

New disease old vaccine: Is recombinant BCG vaccine an answer for COVID-19?

Pathogenicity of acquired immunity in human diseases

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