Regulation of substrate adhesion dynamics during cell motility

SLK-mediated phosphorylation of paxillin is required for focal adhesion turnover and cell migration

“…by inhibitors of actin polymerization or actomyosin contractility leads to the dissolution of focal adhesions [29,30]. Conversely, increases in cellular contractility have been shown to induce the simultaneous growth of both focal adhesions and the attached actin stress fibres [30].…”

Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: A perspective

“…Biochemical and cell imaging data have illuminated an intimate connection between microtubule dynamics and focal adhesion disassembly. Depolymerizing microtubules with nocodazole treatment results in accumulation of enlarged focal adhesions with increased phosphotyrosine content, which has led to the proposal that Rho mediated cell contraction might be countered by the microtubule architecture [73,[133][134][135]. Time lapse imaging studies indicated that growing microtubules target focal adhesions for subsequent disassembly [133,136].…”

“…Depolymerizing microtubules with nocodazole treatment results in accumulation of enlarged focal adhesions with increased phosphotyrosine content, which has led to the proposal that Rho mediated cell contraction might be countered by the microtubule architecture [73,[133][134][135]. Time lapse imaging studies indicated that growing microtubules target focal adhesions for subsequent disassembly [133,136]. A single focal adhesion may be targeted multiple times and a single microtubule tip may target multiple focal adhesions suggesting dynamic interaction of microtubule and actin filament systems and their associated molecular motors [136,137].…”

H2O2Inhibits Proliferation and Mediates Suppression of Migration via DLC1/RhoA Signaling in Cancer Cells

“…It is in agreement with the works mentioned above. As we known, the migration of cancer cells is generated by consecutive contractions of stress fibers which create a tension and drive cell movement (Kaverina et al, 2002). Previous report indicates that 1 μΜ H 2 O 2 increases stress fibers in rat fibroblasts REF-52 (Aghajanian et al, 2009).…”