Abstract:The reaction of fibrinogen and thrombin has been carried out in a Couette-flow apparatus over a range of rates of shear from 0-150 s-1 and at pH’s from 6.4 - 6.8. A minimum is found in the rate of formation of insoluble fibrin at shear rates of 30-60 s-1 (well within the physiological range). The position of the minimum is determined by the concentration of reactants. Rate decreases of up to 50% have been observed. Hirudin quenching of thrombin activity shows that formation of fibrin monomer is unaffected by s… Show more
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