Regulation of Social Recognition Memory in the Hippocampal Circuits

Wang, Xin‐Nian; Zhan, Yang

doi:10.3389/fncir.2022.839931

Cited by 20 publications

(13 citation statements)

References 48 publications

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“…Sensory information in the mPFC encoding the sex and social valence of a conspecific might stem from the hippocampus (Murugan et al, 2017 ). The dorsal CA2 and ventral part of the hippocampus have been tremendously studied in the light of social recognition and memory (for review see Okuyama, 2018 ; Wang and Zhan, 2022 ). As mentioned earlier the latter is of utmost importance during premating choice in order to prevent inbreeding or to mate with the same partner.…”

Section: Neural Circuits For Auditory and Somatosensation In The Cont...mentioning

confidence: 99%

Hearing, touching, and multisensory integration during mate choice

Lenschow

Mendes

Lima

2022

Front. Neural Circuits

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Mate choice is a potent generator of diversity and a fundamental pillar for sexual selection and evolution. Mate choice is a multistage affair, where complex sensory information and elaborate actions are used to identify, scrutinize, and evaluate potential mating partners. While widely accepted that communication during mate assessment relies on multimodal cues, most studies investigating the mechanisms controlling this fundamental behavior have restricted their focus to the dominant sensory modality used by the species under examination, such as vision in humans and smell in rodents. However, despite their undeniable importance for the initial recognition, attraction, and approach towards a potential mate, other modalities gain relevance as the interaction progresses, amongst which are touch and audition. In this review, we will: (1) focus on recent findings of how touch and audition can contribute to the evaluation and choice of mating partners, and (2) outline our current knowledge regarding the neuronal circuits processing touch and audition (amongst others) in the context of mate choice and ask (3) how these neural circuits are connected to areas that have been studied in the light of multisensory integration.

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Section: Neural Circuits For Auditory and Somatosensation In The Cont...mentioning

confidence: 99%

Hearing, touching, and multisensory integration during mate choice

Lenschow

Mendes

Lima

2022

Front. Neural Circuits

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“…Notably, our observation that social recognition is eventually achieved (on T4), indicates that glutamatergic neurons of the PIL are not the only player in encoding social sensory and/or somatosensory information during social recognition and that other neuronal populations of the PIL and/or brain regions may be involved and can eventually compensate for the lack of PIL glutamatergic activity, yet with some delay. For instance, structures such as the lateral septum, hippocampus, amygdala, and medial prefrontal cortex have been identified as key players in the social recognition memory network (35)(36)(37)(38). These regions may receive sensory information via other brain regions and operate within pathways separate from the PIL that could compensate for the decrease in neural activity of PIL glutamatergic neurons, yet with a delay.…”

Section: Discussionmentioning

confidence: 99%

Social Interaction Elicits Activity in Glutamatergic Neurons in the Posterior Intralaminar Complex of the Thalamus

Leithead

Godino

Barbier

et al. 2023

Preprint

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Background The posterior intralaminar (PIL) complex of the thalamus is a multimodal nucleus that has been implicated in maternal behaviors and conspecific social behaviors in male and female rodents. Glutamatergic neurons are a major component of the PIL; however, their specific activity and role during social interactions has not yet been assessed. Methods We used immunohistochemistry for the immediate early gene c-fos as a proxy for neuronal activity in the PIL of mice exposed to a novel social stimulus, a novel object stimulus, or no stimulus. We then used fiber photometry to record neural activity of glutamatergic neurons in the PIL in real-time during social and non-social interactions. Finally, we used inhibitory DREADDs in glutamatergic PIL neurons and tested social preference and social habituation-dishabituation. Results We observed significantly more c-fos-positive cells in the PIL of mice exposed to social versus object or no stimuli. Neural activity of PIL glutamatergic neurons was increased when male and female mice were engaged in social interaction with a same-sex juvenile or opposite-sex adult, but not a toy mouse. Neural activity positively correlated with social investigation bout length and negatively correlated with chronological order of bouts. Social preference was unaffected by inhibition; however, inhibiting activity of glutamatergic neurons in the PIL delayed the time it took female mice to form social habituation. Conclusions Together these findings suggest that glutamatergic PIL neurons respond to social stimuli in both male and female mice and may regulate perceptual encoding of social information to facilitate recognition of social stimuli.

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“…It has been hypothesized that OXT and AVP play differential roles in the sequential phases of SRM. OXT appears to be critical for the acquisition rather than the consolidation phase of memory and AVP appears to be important for SRM consolidation [ 4 , 43 , 44 ]. Further studies are required to address this possibility.…”

Section: Discussionmentioning

confidence: 99%

A dorsal CA2 to ventral CA1 circuit contributes to oxytocinergic modulation of long-term social recognition memory

et al. 2022

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Background Social recognition memory (SRM) is the ability to distinguish familiar from novel conspecifics and is crucial for survival and reproductive success across social species. We previously reported that oxytocin (OXT) receptor (OXTR) signaling in the CA2/CA3a of dorsal hippocampus is essential to promote the persistence of long-term SRM, yet how the endogenous OXT system influences CA2 outputs to regulate long-term SRM formation remains unclear. Methods To achieve a selective deletion of CA2 OXTRs, we crossed Amigo2-Cre mice with Oxtr-floxed mice to generate CA2-specific Oxtr conditional knockout (Oxtr−/−) mice. A three-chamber paradigm test was used for studying SRM in mice. Chemogenetic and optogenetic targeting strategies were employed to manipulate neuronal activity. Results We show that selective ablation of Oxtr in the CA2 suffices to impair the persistence of long-term SRM but has no effect on sociability and social novelty preference in the three-chamber paradigm test. We find that cell-type specific activation of OXT neurons within the hypothalamic paraventricular nucleus enhances long-term SRM and this enhancement is blocked by local application of OXTR antagonist L-368,899 into dorsal hippocampal CA2 (dCA2) region. In addition, chemogenetic neuronal silencing in dCA2 demonstrated that neuronal activity is essential for forming long-term SRM. Moreover, chemogenetic terminal-specific inactivation reveals a crucial role for dCA2 outputs to ventral CA1 (vCA1), but not dorsal lateral septum, in long-term SRM. Finally, targeted activation of the dCA2-to-vCA1 circuit effectively ameliorates long-term SRM deficit observed in Oxtr−/− mice. Conclusions These findings highlight the importance of hippocampal CA2 OXTR signaling in governing the persistence of long-term SRM and identify a hippocampal circuit linking dCA2 to vCA1 necessary for controlling long-term SRM formation.

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Regulation of Social Recognition Memory in the Hippocampal Circuits

Cited by 20 publications

References 48 publications

Hearing, touching, and multisensory integration during mate choice

Hearing, touching, and multisensory integration during mate choice

Social Interaction Elicits Activity in Glutamatergic Neurons in the Posterior Intralaminar Complex of the Thalamus

A dorsal CA2 to ventral CA1 circuit contributes to oxytocinergic modulation of long-term social recognition memory

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