Regulation of Singlet Oxygen Generation Using Single-Walled Carbon Nanotubes

Zhu, Zhi; Tang, Zhixiang; Phillips, Joseph A.; Yang, Ronghua; Wang, Hui; Tan, Weihong

doi:10.1021/ja802913f

Cited by 268 publications

(219 citation statements)

References 22 publications

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“…Carbon nanotubes are another distinct possibility to deliver photosensitizer to required tissues [66]. These structures are synthesized by rolling sheets of carbon into hollow tubes that are single-walled, double-walled or multi-walled.…”

Section: 'Nano' Strategies For Photosensitizermentioning

confidence: 99%

“…Clearly, like standard PS, nano PDT drugs can be used as biosensors as well [174]. However, recent studies link magnetic resonance imaging (MRI) and PDT [66,172] for example for the imaging and treatment of brain tumors [175]. Another example is the combined use of PDT and magnetohypothermia using magnetic nanoparticles [176,177].…”

Section: Additional Applicationsmentioning

confidence: 99%

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Nanodrug applications in photodynamic therapy

Paszko

Ehrhardt

Senge

et al. 2011

Photodiagnosis and Photodynamic Therapy

322

215

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SummaryPhotodynamic therapy (PDT) has developed over last century and is now becoming a more widely used medical tool having gained regulatory approval for the treatment of various diseases such as cancer and macular degeneration. It is a two-step technique in which delivery of a photosensitizing drug is followed by irradiation of light. Activated photosensitizers transfer energy to molecular oxygen which results in generation of reactive oxygen species which in turn cause cells apoptosis or necrosis. Although this modality has significantly improved quality of life and survival time for many cancer patients it still offers significant potential for further improvement. In addition to the development of new PDT drugs, the use of nanosized carriers for photosensitizers is a promising approach which might improve the efficiency of photodynamic activity and which can overcome many side effects associated with classic photodynamic therapy. This review aims at highlighting the different types of nanomedical approaches currently used in PDT and outlines future trends and limitations of nanodelivery of photosensitizers. PDT -photodynamic therapy; PGA -poly(glycolic acid); PGLA -poly(D,L-lactide-coglycolide); PLA -poly(lactic acid); PS -photosensitizer; PEG -polyethylene glycol; ALA  aminolevulinic acid; m-THPC  5,10,15,20-tetra-(m-hydroxyphenyl)chlorine; m-THPP  meso-tetra(p-hydroxyphenyl); PpIX  protoporphyrin; Hp  hematoporphyrin; Pc4  silicon phthalocyanine; Ig  immunoglobulin; Tf  transferrin; TfR  transferrin receptor; VEGF  vascular endothelial growth factor; EPR  enhanced permeability and retention effect; FRET  fluorescence resonance energy transfer; MRI  magnetic resonance imaging; RES  reticuloendothelial system; ROS  reactive oxygen species; NP  nanoparticle; ND -nanodiamonds; SNP  silica nanoparticle; AMD  age-related macular degeneration; CNV  choroidal neovascularization; PTT  photothermal therapy;

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Section: 'Nano' Strategies For Photosensitizermentioning

confidence: 99%

Section: Additional Applicationsmentioning

confidence: 99%

Nanodrug applications in photodynamic therapy

Paszko

Ehrhardt

Senge

et al. 2011

Photodiagnosis and Photodynamic Therapy

322

215

View full text Add to dashboard Cite

show abstract

“…In a typical experiment, GNRs were synthesized according to the seed-mediated template-assisted protocol [19,28]. Twenty milliliters of the GNRs solution was centrifuged at 9600 rpm for 15 min.…”

Section: Synthesis Of Silica-modified Gold Nanorodsmentioning

confidence: 99%

“…Gold nanorods (GNRs), strongly light enhanced absorption in NIR and plasmon resonance enhanced properties, are attracting intensive scientific interest for their unique properties and potential applications such as photothermal therapy [18], biosensing [19], molecular imaging [20], and gene delivery [21] for cancer treatment. However, the toxicity derived from a large amount of the surfactant cetyltrimethylammonium bromide (CTAB) during GNRs synthesis severely limits their biomedical applications [22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of near-infrared region absorption enhancer carbon nanotubes hybridmaterials

Huang¹,

Zhang²,

Xu³

et al. 2010

Nano BioMed ENG

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“…singlet oxygen, 12,13 one of the most important cytotoxic agents for photodynamic therapy. The publications highlighted in this issue of JACS Select illustrate especially well how biocomposite nanoparticles are currently being designed for new and often unprecedented functions.…”

mentioning

confidence: 99%

Chemistry at the Nano−Bio Interface

2009

J. Am. Chem. Soc.

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The interface of biology and inorganic materials represents one of the fastest growing and most promising areas of nanotechnology. The fifth issue of JACS Select contains 22 Communications and Articles from 2008 and early 2009 that illustrate the breadth and creative energy of this young field.Although the use of colloidal particles of metals and semiconductors as pigments dates back many centuries, and although the recipe for stable 6 nm diameter particles of gold ("Ruby gold") was famously devised by Faraday in 1857, 1 the unique properties of nanomaterials and their promise for applications in biochemistry, cell biology, and medicine have only recently been appreciated. Prior to the 1990s, the principal role of inorganic colloids in biological research was as high-contrast stains for electron microscopy. 2 A paradigm shift occurred in 1996, when Mirkin, Alivisatos, and co-workers coupled metal nanoparticles to DNA. 3 Their experiments demonstrated not only that DNA could be used for the organization of nanostructures, as had been suggested in earlier experiments by Seeman, 4 but also that nanoparticles were highly sensitive spectroscopic reporters for the base-pairing of DNA. Advances in the synthesis of crystalline, size-selected, and epitaxially capped semiconductor quantum dots early in the 1990s 5 set the stage for their conjugation to antibodies that could target them to specific biological molecules in cells. 6 These experiments demonstrated that brightly luminescent quantum dots were effective for intracellular imaging and were potentially competitive in that role with fluorescent molecules and proteins. Almost simultaneously, techniques were devised for controlling the size and understanding the magnetic behavior of transition metal oxide and magnetic alloy nanoparticles. By the end of the 1990s, bioconjugated magnetic nanoparticles were used for sophisticated imaging experiments 7 as well as for the targeted destruction of cancer cells. 8 Carbon nanotubes were discovered in the early 1990s, and versatile techniques were also developed for growing semiconductor nanowires. 9,10 Nanotubes and nanowires, because of their extreme aspect ratio and sensitivity to charge-transfer interactions, proved to be very sensitive platforms for the detection of biomolecules. 11 Research in the current decade has led to a much more sophisticated set of tools for controlling the size, shape, dispersity, and surface chemistry of nanoparticles. The complexity of nanoparticle structures s as nanoshells, prisms, Janus particles, derivatized nanotubes, core-shell particles, and striped nanowires, to name a few s offers new tools to tailor particles to specific problems in ultratrace detection, imaging, drug delivery, DNA/RNA delivery, and therapy. Sophisticated schemes for signal amplification, enhanced bioaffinity through multivalency, and cooperative binding highlight the synergy of nanoparticles as platforms for biological molecular recognition. The deliberate design of nanoparticles for biological applications, for exa...

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Regulation of Singlet Oxygen Generation Using Single-Walled Carbon Nanotubes

Cited by 268 publications

References 22 publications

Nanodrug applications in photodynamic therapy

Nanodrug applications in photodynamic therapy

Preparation and characterization of near-infrared region absorption enhancer carbon nanotubes hybridmaterials

Chemistry at the Nano−Bio Interface

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