Regulation of serum lipidomics and amino acid profiles of rats with acute myocardial ischemia by Salvia miltiorrhiza and Panax notoginseng herb pair

Tao, Hui-Juan; Yang, Xinyu; Wang, Wen-xiao; Yue, Shi‐Jun; Pu, Zong-Jin; Huang, Yu‐Ning; Shi, Xu-Qin; Chen, Jiaqian; Zhou, Guisheng; Chen, Yanyan; Zhao, Ming; Tang, Yuping; Duan, Jin‐Ao

doi:10.1016/j.phymed.2019.153162

Cited by 20 publications

(8 citation statements)

References 38 publications

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“…The levels of HDL-C and apoA1 were significantly higher than before treatment. The differences were statistically significant (P < 0.05) 9 . The Salvia miltiorrhiza (Danshen) in the prescription can expand the coronary artery and resist platelet aggregation, thereby inhibiting the formation of thrombus 10 .…”

Section: Introductionmentioning

confidence: 84%

Exploring the mechanism of Yixinyin for myocardial infarction by weighted co-expression network and molecular docking

Huo

Liu³

2021

Sci Rep

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Yixinyin, the traditional Chinese medicine, has the effects of replenishing righteous qi, and promoting blood circulation to eliminate blood stagnation. It is often used to treat patients with acute myocardial infarction (MI). The purpose of our study is to explore the key components and targets of Yixinyin in the treatment of MI. In this study, we analyzed gene expression data and clinical information from 248 samples of MI patients with the GSE34198, GSE29111 and GSE66360 data sets. By constructing a weighted gene co-expression network, gene modules related to myocardial infarction are obtained. These modules can be mapped in Yixinyin PPI network. By integrating differential genes of healthy/MI and unstable angina/MI, key targets of Yixinyin for the treatment of myocardial infarction were screened. We validated the key objectives with external data sets. GSEA analysis is used to identify the biological processes involved in key targets. Through molecular docking screening, active components that can combine with key targets in Yixinyin were obtained. In the treatment of myocardial infarction, we have obtained key targets of Yixinyin, which are ALDH2, C5AR1, FOS, IL1B, TLR2, TXNRD1. External data sets prove that they behave differently in the healthy and MI (P < 0.05). GSEA enrichment analysis revealed that they are mainly involved in pathways associated with myocardial infarction, such as viral myocarditis, VEGF signaling pathway and type I diabetes mellitus. The docking results showed that the components that can be combined with key targets in YixinYin are Supraene, Prostaglandin B1, isomucronulatol-7,2′-di-O-glucosiole, angusifolin B, Linolenic acid ethyl ester, and Mandenol. For that matter, they may be active ingredients of Yixinyin in treating MI. These findings provide a basis for the preliminary research of myocardial infarction therapy in traditional Chinese medicine and provide ideas for the design of related drugs.

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Section: Introductionmentioning

confidence: 84%

Exploring the mechanism of Yixinyin for myocardial infarction by weighted co-expression network and molecular docking

Huo

Liu³

2021

Sci Rep

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“…Platelet and blood lipids play crucial roles in CAD 17,18 . PNS has been demonstrated to promote lipolysis and reduce lipid synthesis, thereby improve the metabolism of serum lipids in multiple ways 19 . Aside from that, PNS inhibits platelet activation 20,21 .…”

Section: Discussionmentioning

confidence: 99%

Xuesaitong Capsule For Patients After Percutaneous Coronary Intervention For Unstable Angina: Study Protocol For a Randomized Controlled Trial

Duan

et al. 2021

Preprint

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• Background: This study was designed to investigate the effect of Xuesaitong (XST) capsule added to conventional treatment in patients after percutaneous coronary intervention (PCI) for unstable angina (UA).• Methods: This is a 12-week, randomized, multi-center, double-blinded, placebo-controlled clinical trial. A total of 120 patients with UA will be recruited and randomly allocated in a 1:1 ratio to receive XST or placebo (2 capsules twice per day) on the background of conventional treatment. The changed level of high-sensitivity C-reactive protein from baseline to week 12 is the primary outcome. Secondary outcomes include tumor necrosis factor-α, interleukin-6, platelet aggregation, blood lipid, angina symptoms and ST segment deviation in electrocardiogram. The safety of XST will be monitored during the trial.• Discussion: This study will provide an evidence regarding the efficacy and safety of XST on the background of conventional medical treatment in patients after PCI for UA.• Trial registration: Chinese Clinical Trial Registry, ChiCTR2000032152. Registered on 14 January 2020.

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“…Abnormal lipid metabolism is often accompanied by oxidative stress and inflammatory reaction, which are taken part in the process of cardiac dysfunction (Dhivya et al, 2017). Recent studies found that the decreased levels of the fatty acids including glycerophospholipids, glycerolipids and sphingolipids were detected in the ischemic injury (Tao et al, 2020). In transverse aortic constriction (TAC) models, the circulating lipids were also changed, such as ceramide 1‐phosphate (CerP), circulating fatty acids, glycerides, and diglycerides, which might affect fatty acids oxidation and mitochondrial function during cardiac dysfunction (Goldenberg et al, 2019; Lahey et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

The anticardiac fibrosis of total alkaloids of Plumula nelumbinis by regulating circulating lipidomic profile: In vivo study

Shi

Yang

et al. 2022

Journal of Food Biochemistry

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Plumula nelumbinis has great medicinal potential as a herbal tea and traditional drug in China. This study was aimed to evaluate the anticardiac fibrosis of the total alkaloids of P. nelumbinis (TAP). TAP at 50 mg/kg/day significantly ameliorated isoproterenolinduced cardiac fibrosis in mice (p < .05). The circulating lipidomics study revealed that TAP improved the lipid metabolism dysfunction in cardiac fibrosis. Meanwhile, TAP suppressed the lipid accumulation, decreased MDA level (p < .01) in heart, and increased FFA level (p < .01). Furthermore, integrating lipidomics, chemical profiles and pharmacology network analysis found that AMPK and PI3K/Akt signaling pathways were the potential targeted pathway by TAP to regulate lipid metabolism dysfunction including glycerophospholipid metabolism. Above all, TAP provided a potential anticardiac fibrosis effect partly through regulation of lipid profiles. Practical applications1. The total alkaloids of Plumula nelumbinis (TAP) suppressed ISO-induced cardiac fibrosis in mice.2. Network pharmacology analysis and experiments revealed that TAP-regulated AMPK and PI3K/Akt signaling pathway to improve lipid metabolism disorder in cardiac fibrosis.3. This study provides evidence to the therapeutic potential of TAP in the treatment of ISO-induced cardiac fibrosis and could be a drug candidate for prevention and treatment of cardiac fibrosis.

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Regulation of serum lipidomics and amino acid profiles of rats with acute myocardial ischemia by Salvia miltiorrhiza and Panax notoginseng herb pair

Cited by 20 publications

References 38 publications

Exploring the mechanism of Yixinyin for myocardial infarction by weighted co-expression network and molecular docking

Exploring the mechanism of Yixinyin for myocardial infarction by weighted co-expression network and molecular docking

Xuesaitong Capsule For Patients After Percutaneous Coronary Intervention For Unstable Angina: Study Protocol For a Randomized Controlled Trial

The anticardiac fibrosis of total alkaloids of Plumula nelumbinis by regulating circulating lipidomic profile: In vivo study

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