Regulation of Selective B Cell Autophagy by the Pro-oxidant Adaptor p66SHC

Onnis, Anna; Cassioli, Chiara; Finetti, Francesca; Baldari, Cosima T.

doi:10.3389/fcell.2020.00193

Cited by 6 publications

(5 citation statements)

References 83 publications

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“…The role of ROS on B cells is complex. Studies have shown that low concentrations of ROS can promote the activation and proliferation of B cells, while high concentrations of ROS can prevent B cell survival through autophagy pathways (49,50). In the present study, we found that STEAP3 high-expression ccRCC holds obvious remodeling of the extracellular matrix, and its immune infiltration pattern was significantly different from STEAP3 low-expression ccRCC.…”

Section: Discussionmentioning

confidence: 41%

STEAP3 can predict the prognosis and shape the tumor microenvironment of clear cell renal cell carcinoma

Zheng

et al. 2022

BMC Cancer

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Clear cell renal cell carcinoma (ccRCC) is a common malignant tumor of the urinary system characterized by poor prognosis and difficult treatment. It has been reported that iron metabolism dysregulation is a common phenomenon in ccRCC and is closely related to the process of ccRCC. But still now, the exact function and underlying mechanisms of iron metabolism dysregulation in ccRCC have not been fully elucidated. In this study, we comprehensively investigated the prognostic value and potential role of STEAP3 (an iron metabolism-related gene) in ccRCC. STEAP3 is significantly up-regulated in ccRCC. High STEAP3 expression is associated with gender, hemoglobin level, pathological grade, tumor stage and significantly predicts an unfavorable prognosis of ccRCC patients. Functional enrichment analysis and evaluation of the tumor microenvironment indicated that STEAP3 was involved in the remodeling of tumor extracellular matrix and the shaping of an immune-suppressive tumor microenvironment to promote tumor metastasis and evade immune killing. Besides, the expression of STEAP3 is also associated with the expression of various immune checkpoint molecules and the IC50 of targeted drugs. Finally, we verified STEAP3 by RT-qPCR and IHC staining. In conclusion, we found that STEAP3 can serve as a candidate prognostic biomarker for ccRCC, and targeting STEAP3 and its biological processes may provide new references for the individualized treatment of ccRCC.

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Section: Discussionmentioning

confidence: 41%

STEAP3 can predict the prognosis and shape the tumor microenvironment of clear cell renal cell carcinoma

Zheng

et al. 2022

BMC Cancer

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“…p66shc, a prooxidant isoform of the ShcA adaptor protein family, has the same modular structure of p52Shc/p46Shc (SH2-CH1-PTB) and an additional N-terminal CH2 domain containing a particular phosphorylated serine residue at position 36 (Ser36) [ 39 , 40 ]. Oxidative stress induces ser36 phosphorylation to trigger p66Shc activation, which, in turn, promotes electron transfer from cytochrome c to oxygen, thereby increasing the generation of hydrogen peroxide [ 41 , 42 ].…”

Section: Sources Of Intracellular Ros In Pcamentioning

confidence: 99%

Roles of Reactive Oxygen Species in Biological Behaviors of Prostate Cancer

Han

Wang

et al. 2020

BioMed Research International

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Prostate cancer (PCa), known as a heterogenous disease, has a high incidence and mortality rate around the world and seriously threatens public health. As an inevitable by-product of cellular metabolism, reactive oxygen species (ROS) exhibit beneficial effects by regulating signaling cascades and homeostasis. More and more evidence highlights that PCa is closely associated with age, and high levels of ROS are driven through activation of several signaling pathways with age, which facilitate the initiation, development, and progression of PCa. Nevertheless, excessive amounts of ROS result in harmful effects, such as genotoxicity and cell death. On the other hand, PCa cells adaptively upregulate antioxidant genes to detoxify from ROS, suggesting that a subtle balance of intracellular ROS levels is required for cancer cell functions. The current review discusses the generation and biological roles of ROS in PCa and provides new strategies based on the regulation of ROS for the treatment of PCa.

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“…For example, low levels of ROS can induce the differentiation of B cells into plasma cells [109]. In addition, ROS can regulate apoptosis and autophagy in B cells [110]. For example, studies have found that the p66SHC protein can affect B cells in different ways.…”

Section: Ros and Apcsmentioning

confidence: 99%

Oxidative Stress in Cancer Immunotherapy: Molecular Mechanisms and Potential Applications

et al. 2022

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Immunotherapy is an effective treatment option that revolutionizes the management of various cancers. Nevertheless, only a subset of patients receiving immunotherapy exhibit durable responses. Recently, numerous studies have shown that oxidative stress induced by reactive oxygen species (ROS) plays essential regulatory roles in the tumor immune response, thus regulating immunotherapeutic effects. Specifically, studies have revealed key roles of ROS in promoting the release of tumor-associated antigens, manipulating antigen presentation and recognition, regulating immune cell phenotypic differentiation, increasing immune cell tumor infiltration, preventing immune escape and diminishing immune suppression. In the present study, we briefly summarize the main classes of cancer immunotherapeutic strategies and discuss the interplay between oxidative stress and anticancer immunity, with an emphasis on the molecular mechanisms underlying the oxidative stress-regulated treatment response to cancer immunotherapy. Moreover, we highlight the therapeutic opportunities of manipulating oxidative stress to improve the antitumor immune response, which may improve the clinical outcome.

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Regulation of Selective B Cell Autophagy by the Pro-oxidant Adaptor p66SHC

Cited by 6 publications

References 83 publications

STEAP3 can predict the prognosis and shape the tumor microenvironment of clear cell renal cell carcinoma

STEAP3 can predict the prognosis and shape the tumor microenvironment of clear cell renal cell carcinoma

Roles of Reactive Oxygen Species in Biological Behaviors of Prostate Cancer

Oxidative Stress in Cancer Immunotherapy: Molecular Mechanisms and Potential Applications

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