Regulation of secondary metabolite biosynthesis in Monascus purpureus via cofactor metabolic engineering strategies

Li, Jun; Wu, Jingyan; Cai, Xinru; Zhang, Song; Liang, Ying; Lin, Qinlu

doi:10.1016/j.fm.2020.103689

Cited by 25 publications

(28 citation statements)

References 40 publications

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“…•T. purpureogenus was reported to have a pH-related biosynthesis of yellow piments in Czapeck yeast medium [84].…”

Section: Yellow Azaphilonesmentioning

confidence: 99%

“…•Optimum biomass production, in addition to increasing the presence red pigments can be achieved growing T. purpureogenus strain F in Czapek yeast medium at pH 5 [84].…”

Section: Red Azaphilonesmentioning

confidence: 99%

“…Therefore, a big challenge in pigments production is to obtain pure extracts, containing fewer substances and, preferably, with only one color [ 19 ]. Figure 12 presents some fungal species and associated fermentative parameters that resulted in the production of yellow [ 66 , 80 , 81 , 82 , 83 , 84 ], orange [ 14 , 85 ] or red [ 14 , 79 , 85 , 86 , 87 , 88 , 89 ] pigments. However, in most of the works, yellow, orange and red azaphilones are produced simultaneously (cocktail pigments phenomenon) in different proportions.…”

Section: Processing and Innovations In Azaphilones Productionmentioning

confidence: 99%

“…Yang et al [ 16 ] reported that the expression of key genes for Monascus pigment biosynthesis was significantly up regulated in the presence of sodium nitrate. Increase in total pigment production and yellow pigment proportion was reported for a M. purpureus strain (LQ-6), after adding exogenous cofactor methyl viologen and rotenone (1.0 mg/L) to the submerged batch-fermentation [ 84 ].…”

Section: Processing and Innovations In Azaphilones Productionmentioning

confidence: 99%

“…Figure 12.Conditions reported for color-directed production of yellow, orange and red azaphilones[14,67,[80][81][82][83][84][85][86][87][88][89][90].…”

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confidence: 99%

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Recent Findings in Azaphilone Pigments

Pimenta

Gomes

Cardoso

et al. 2021

JoF

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Filamentous fungi are known to biosynthesize an extraordinary range of azaphilones pigments with structural diversity and advantages over vegetal-derived colored natural products such agile and simple cultivation in the lab, acceptance of low-cost substrates, speed yield improvement, and ease of downstream processing. Modern genetic engineering allows industrial production, providing pigments with higher thermostability, water-solubility, and promising bioactivities combined with ecological functions. This review, covering the literature from 2020 onwards, focuses on the state-of-the-art of azaphilone dyes, the global market scenario, new compounds isolated in the period with respective biological activities, and biosynthetic pathways. Furthermore, we discussed the innovations of azaphilone cultivation and extraction techniques, as well as in yield improvement and scale-up. Potential applications in the food, cosmetic, pharmaceutical, and textile industries were also explored.

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“…•T. purpureogenus was reported to have a pH-related biosynthesis of yellow piments in Czapeck yeast medium [84].…”

Section: Yellow Azaphilonesmentioning

confidence: 99%

“…•Optimum biomass production, in addition to increasing the presence red pigments can be achieved growing T. purpureogenus strain F in Czapek yeast medium at pH 5 [84].…”

Section: Red Azaphilonesmentioning

confidence: 99%

Section: Processing and Innovations In Azaphilones Productionmentioning

confidence: 99%

Section: Processing and Innovations In Azaphilones Productionmentioning

confidence: 99%

“…Figure 12.Conditions reported for color-directed production of yellow, orange and red azaphilones[14,67,[80][81][82][83][84][85][86][87][88][89][90].…”

mentioning

confidence: 99%

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Recent Findings in Azaphilone Pigments

Pimenta

Gomes

Cardoso

et al. 2021

JoF

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Strategies on improvement of pigment formation and reduction of citrinin in Monascus fermentation

Mou

Pan

Jiang

et al. 2022

Biofuels Bioprod Bioref

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Monasucs pigments, as natural food colorants, have worldwide popularity owing to their antibacterial ability and superior coloring characteristics, as well as various applications in food, medicine, cosmetics and several other fields. Therefore, there is a considerable demand of pigments and various approaches have been conducted to improve pigment production. However, citrinin, which causes great harm to human health, is undesirably generated during the fermentation. Thus, great efforts have been made to increase pigment production and decrease citrinin formation by culture media and condition optimization, mutation breeding or genetic engineering. For the purpose of giving insight for further research, this article makes a summary of existing study advances in Monasucs pigment production. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd.

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Current Status of Metabolic Engineering of Medicinal Plants for Production of Plant-Derived Secondary Metabolites

Halder

Roy

2023

Sustainable Development and Biodiversity

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Regulation of secondary metabolite biosynthesis in Monascus purpureus via cofactor metabolic engineering strategies

Cited by 25 publications

References 40 publications

Recent Findings in Azaphilone Pigments

Recent Findings in Azaphilone Pigments

Strategies on improvement of pigment formation and reduction of citrinin in Monascus fermentation

Current Status of Metabolic Engineering of Medicinal Plants for Production of Plant-Derived Secondary Metabolites

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