Regulation of SCN3B/scn3b by Interleukin 2 (IL-2): IL-2 modulates SCN3B/scn3b transcript expression and increases sodium current in myocardial cells

Zhao, Yuanyuan; Sun, Qiaobing; Zeng, Zhipeng; Li, Qianqian; Zhou, Shuyao; Zhou, Ming; Xue, Yumei; Cheng, Xiang; Wang, Qing Kenneth; Tu, Xin

doi:10.1186/s12872-015-0179-x

Cited by 62 publications

(53 citation statements)

References 21 publications

(26 reference statements)

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“…Gene expression of pro-inflammatory factors associated to inflammatory response (IFN-γ, transcription factor T-bet, GATA-3; FoxP3 and CTLA-4; IL-17 and IL-18) were upregulated in heart samples of chronic Chagasic patients [24] and its inflammatory environment has been reported as inductor of gene expression related with heart failure [25] and gap junction dysfunction during Chagas disease [26], possibly explaining this fact the electrical disturbances observed in patients. Interestingly and closely related with our results, IL-2 was able to induce in vitro the expression of SCN3B and sodium current density [27], increasing of atrial action potential duration [28] and IL-2 has been linked to prognosis for atrial fibrillation in patients [29]. Additionally, Cx43 gene expression, a key protein of gap junctions tightly related with action potential spreading onto the heart, has been reported as impaired in Chagasic cardiomyopathy, reinforcing the possible association between inflammation and altered electrical function in Chagasic patients [30] and its fact possibly explains the positive effect of amiodarone treatment during Chagas disease [31].…”

Section: Discussionsupporting

confidence: 87%

Differential cytokine profiling in Chagasic patients according to their arrhythmogenic-status

Rodríguez-Angulo

Márques²,

Mendoza³

et al. 2017

BMC Infect Dis

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BackgroundChagas disease is caused by the protozoan Trypanosoma cruzi and is characterized by heart failure and sudden death. Identifying which factors are involved in evolution and treatment response is actually challenging.Thus, the aim of this work was to determine the Th1/Th17 (IL-6, IL-2, TNF, IL-17 and IFN-γ) and Th2 (IL-4 and IL-10) serum profile in Venezuelan Chagasic patients stratified according amiodarone treatment, hypertension and arrhythmias.MethodsSera from 38 chagasic patients were analyzed to determine the level of cytokines by Multiplexed Bead-Based Immunoassays. ANOVA test was applied to determine differences for each group. Additionally, a Linear Discriminant Analysis (LDA) was applied to observe the accuracy of different cytokines to discriminate between the groups.ResultsThe levels of several cytokines were significantly higher in the high-risk of sudden death and untreated group. LDA showed that IL-2, IFN-γ and IL-10 were the best cytokines for discriminating between high-risk of sudden death and untreated patients versus low-risk of sudden death, treated and control groups.ConclusionsHigh IL-2 levels seem to identify patients with high-risk of sudden death and seems adequate as treatment efficacy marker. To our knowledge, this is the first report about the anti-inflammatory role of the amiodarone in Chagas disease, suggesting an inmunomodulatory effect that may be exploited as coadjutant therapy in chronic Chagas disease.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-017-2324-x) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 87%

Differential cytokine profiling in Chagasic patients according to their arrhythmogenic-status

Rodríguez-Angulo

Márques²,

Mendoza³

et al. 2017

BMC Infect Dis

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“…Recent studies from Ghana and other sub-Saharan African countries indicate that the prevalence of cardiovascular diseases (CVDs) is increasing at an alarming rate [ 1 , 2 ]. A recent meta-analysis reported that CVDs in sub-Saharan Africa cause a million deaths, constituting 38.3% of non-communicable disease deaths, and 11.3% of deaths from all causes [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Metabolic syndrome and parental history of cardiovascular disease in young adults in urban Ghana

et al. 2017

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BackgroundMetabolic syndrome (MetS) in young adults poses significant cardiovascular diseases (CVD) risk for later years. Parental history of CVDs is known to affect the prevalence of CVD risk in adulthood. In sub-Saharan Africa, the burden of MetS in young adults and its relationship with parental CVDs is largely unknown.We studied the gender-specific prevalence of MetS and its association with parental history of diabetes, hypertension and CVDs in young adults resident in urban Ghana.MethodsIn a cross-sectional design, 364 young adults aged 20–30 years were randomly recruited from students of University of Ghana. A structured questionnaire was used to collect data on demography, lifestyle, medical and parental medical history. Anthropometric indices and blood pressures were measured. Fasting blood samples were collected to measure plasma levels of glucose, lipid profile, urea and creatinine. MetS was defined according to the Joint Scientific Statement criteria.ResultsThe prevalence of MetS was 12.4%, higher in females than male participants (18.4% vs 5.7, p = 0.019). Female participants had higher levels of all the components of MetS than the male participants. Compared to participants with no history of parental CVDs, participants with parental CVDs had a higher proportion of abdominal obesity. A positive history of parental CVDs was associated with increase in odds of MetS [OR (95% CI): 1.23 (1.12–3.04), p = 0.037].ConclusionIn our study population, there is relatively high prevalence of MetS; higher in females compared to male participants. Parental history of CVDs was associated with MetS.

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“…Chronic adult diseases including hypertension, obesity, resulting metabolic syndrome and diabetes are now common [ 1 , 2 ]. Consequently, premature macro- and micro-vascular conditions, including hypertensive heart failure (if not yet much coronary disease), stroke, renal failure, and arterial complications of Type 2 diabetes (T2D) now burden patients and health services [ 3 , 4 ]. Arterial stiffness is a powerful predictor of such future cardiovascular (CV) complications and all-cause mortality in all patient groups studied, even after adjusting for age, blood pressure (BP) or other risk factors [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Arterial stiffness in hypertensive and type 2 diabetes patients in Ghana: comparison of the cardio-ankle vascular index and central aortic techniques

et al. 2016

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BackgroundDiabetes and hypertension increase arterial stiffness and cardiovascular events in all societies studied so far; sub-Saharan African studies are sparse. We investigated factors affecting arterial function in Ghanaians with diabetes, hypertension, both or neither.MethodTesting the hypothesis that arterial stiffness would progressively increase from controls to multiply affected patients, 270 participants were stratified into those with diabetes or hypertension only, with both, or without either. Cardio-ankle vascular index (CAVI), heart–ankle pulse wave velocity (haPWV), aortic PWV (PWVao) by Arteriograph, aortic and brachial blood pressures (BP), were measured.ResultsIn patients with both diabetes and hypertension compared with either alone, values were higher of CAVI (mean ± SD, 8.3 ± 1.2 vs 7.5 ± 1.1 and 7.4 ± 1.1 units; p < 0.05), PWVao (9.1 ± 1.4 vs 8.7 ± 1.9 and 8.1 ± 0.9 m/s; p < 0.05) and haPWV (8.5 ± 1 vs 7.9 ± 1 and 7.2 ± 0.7 m/s; p < 0.05) respectively. In multivariate analysis, age, having diabetes or hypertension and BMI were independently associated with CAVI in all participants (β = 0.49, 0.2, 0.17 and -0.2 units; p < 0.01, respectively). Independent determinants of PWVao were heart rate, systolic BP and age (β = 0.42, 0.27 and 0.22; p < 0.01), and for haPWV were systolic BP, age, BMI, diabetes and hypertension status (β = 0.46, 0.32, -0.2, 0.2 and 0.11; p < 0.01).ConclusionIn this sub-Saharan setting with lesser atherosclerosis than the western world, arterial stiffness is significantly greater in patients with coexistent diabetes and hypertension but did not differ between those with either diabetes or hypertension only. Simple, reproducibly measured PWV/CAVI may offer effective and efficient targets for intervention.Electronic supplementary materialThe online version of this article (doi:10.1186/s12902-016-0135-5) contains supplementary material, which is available to authorized users.

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Regulation of SCN3B/scn3b by Interleukin 2 (IL-2): IL-2 modulates SCN3B/scn3b transcript expression and increases sodium current in myocardial cells

Cited by 62 publications

References 21 publications

Differential cytokine profiling in Chagasic patients according to their arrhythmogenic-status

Differential cytokine profiling in Chagasic patients according to their arrhythmogenic-status

Metabolic syndrome and parental history of cardiovascular disease in young adults in urban Ghana

Arterial stiffness in hypertensive and type 2 diabetes patients in Ghana: comparison of the cardio-ankle vascular index and central aortic techniques

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