Regulation of salivary gland function by autonomic nerves

Proctor, Gordon; Carpenter, Guy

doi:10.1016/j.autneu.2006.10.006

Cited by 573 publications

(499 citation statements)

References 99 publications

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“…These paracrine factors downstream of Shh signaling interact with receptors on endothelial cells 40 and parasympathetic neurons and their projections 7,41 to preserve the microvasculature and parasympathetic innervation, which leads to the restoration of salivary gland function likely by improving blood supply and activating the cholinergic receptor muscarinic 1 (Chrm1)/heparin-binding EGF-like growth factor (HB-EGF) pathway with acetylcholine to promote proliferation of Chrm1 + epithelial cells in both acini and ducts of adult salivary glands. 42,43 Further investigation of other responses triggered by transient Hh activation, beneficial or harmful to restoration of the salivary gland, will improve the efficacy of this approach and facilitate its potential clinical application. …”

Section: Discussionmentioning

confidence: 99%

Rescue Effects and Underlying Mechanisms of IntraglandShhGene Delivery on Irradiation-Induced Hyposalivation

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Rescue Effects and Underlying Mechanisms of IntraglandShhGene Delivery on Irradiation-Induced Hyposalivation

et al. 2016

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“…Furthermore, cephalic-phase salivation, which can be as copious as the flow rate resulting from feed ingestion, affects taste perception in several ways, including dilution of tastants and buffering of hydrogen ions. Smell, taste or chewing stimuli evoke up to 10-fold increases in salivation (Proctor and Carpenter 2007) and other digestive secretions such as gastric, bile, pancreatic and intestinal mucosa secretions (Platel and Srinivasam 2004). Salivation also influences olfactory notes by altering the concentration of odorants that are transported to the olfactory epithelium retronasally (Mattes 2000).…”

Section: Short-term Post-ingestive Factorsmentioning

confidence: 99%

Unfolding the codes of short-term feed appetence in farm and companion animals. A comparative oronasal nutrient sensing biology review

Roura¹,

Humphrey²,

Tedó³

et al. 2008

Can. J. Anim. Sci.

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Roura, E., Humphrey, B., Tedo´, G. and Ipharraguerre, I. 2008. Unfolding the codes of short-term feed appetence in farm and companion animals. A comparative oronasal nutrient sensing biology review. Can. J. Anim. Sci. 88: 535Á558. The evolution of the chemical senses has resulted in a sensory apparatus for high taste and smell acuity in mammals and birds to ensure self-nourishment. Such peripheral chemosensory systems function as a code to unfold the nutritional value of feedstuffs. Food ingestion simultaneously evokes odor, taste and thermo-mechanical (somatosensing) sensations. Olfaction represents the capacity to identify feed volatiles that are predominantly derived from essential nutrients in plants.Comparative biology of olfaction shows that primates and chickens have a smaller olfactory epithelium and fewer olfactory receptor (OR) genes than non-primate mammals studied to date including farm and companion animals, such as the pig, the cow, the dog, the cat and the horse. A significant proportion of the total OR genes in mammals and birds have lost their functionality (pseudogenes) in a process that seems to reflect a decrease in the animal's reliance on the sense of smell, particularly in humans and cows. The taste system allows animals to recognize a diverse repertoire of nutrient (sugars, amino acids, salts, acids and fats) or toxic related chemical entities that provide valuable information about the quality of food. Taste senses non-volatile molecules in the oral cavity through taste receptors (TR). The TR are expressed in the sensory cells forming the taste buds of the tongue's papillae. Taste cells are linked to a network of solitary chemosensory cells diffused through many non-taste tissues involved in metabolic homeostasis. The number of functional taste receptor genes (TASR) in humans is equivalent to that in other mammals and superior to that in chickens. The TASR family 1 (TAS1R coding for umami and sweet TR) is conserved, in number and type, across the species evaluated, with the exception of the sweet receptor in chicken and feline species. The TASR family 2 (TAS2R coding for bitter TR) shows a strong adaptive capacity to dietary sources and digestive physiology across vertebrates. Pseudogenization (loss of gene functionality) in the TAS2R family seems to be a frequent strategy. The implications of oronasal nutrient sensing related to comparative animal feeding strategies and behaviors such as neophobia, feed refusal and hedonic preferences are discussed. Feed palatability and appetence might be one of the main driving forces in short-term feed consumption. Finally, practical applications relevant to animal production are outlined.Key words: Nutrient sensing, taste, olfaction, somatosensing, feed intake, farm, companion animals Roura, E., Humphrey, B., Tedo´, G. et Ipharraguerre, I. 2008. Le code de l'appe´tence a`court terme chez les animaux domestiques et de compagnie. Biologie comparative de la de´tection bucco-nasale des e´le´ments nutritifs. Can. J. Anim. Sci. 88: 535Á558. En e´voluant, ...

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“…Two types of salivary glands exist in mammals: the major glands, which produce 90% of the saliva, and the minor glands [32,33]. All major salivary glands are originated from the embryonic ectoderm and include the parotid, sublingual and submandibular glands.…”

Section: Innervation and Salivary Glandsmentioning

confidence: 99%

Roles of innervation in developing and regenerating orofacial tissues

Pagella

Jiménez-Rojo

Mitsiadis

2014

Cell. Mol. Life Sci.

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The head is innervated by 12 cranial nerves (I-XII) that regulate its sensory and motor functions. Cranial nerves are composed of sensory, motor, or mixed neuronal populations. Sensory neurons perceive generally somatic sensations such as pressure, pain, and temperature. These neurons are also involved in smell, vision, taste, and hearing. Motor neurons ensure the motility of all muscles and glands. Innervation plays an essential role in the development of the various orofacial structures during embryogenesis. Hypoplastic cranial nerves often lead to abnormal development of their target organs and tissues. For example, Möbius syndrome is a congenital disease characterized by defective innervation (i.e., abducens (VI) and facial (VII) nerves), deafness, tooth anomalies, and cleft palate. Hence, it is obvious that the peripheral nervous system is needed for both development and function of orofacial structures. Nerves have a limited capacity to regenerate. However, neural stem cells, which could be used as sources for neural tissue maintenance and repair, have been found in adult neuronal tissues. Similarly, various adult stem cell populations have been isolated from almost all organs of the human body. Stem cells are tightly regulated by their microenvironment, the stem cell niche. Deregulation of adult stem cell behavior results in the development of pathologies such as tumor formation or early tissue senescence. It is thus essential to understand the factors that regulate the functions and maintenance of stem cells. Yet, the potential importance of innervation in the regulation of stem cells and/or their niches in most organs and tissues is largely unexplored. This review focuses on the potential role of innervation in the development and homeostasis of orofacial structures and discusses its possible association with stem cell populations during tissue repair.

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Regulation of salivary gland function by autonomic nerves

Cited by 573 publications

References 99 publications

Rescue Effects and Underlying Mechanisms of IntraglandShhGene Delivery on Irradiation-Induced Hyposalivation

Rescue Effects and Underlying Mechanisms of IntraglandShhGene Delivery on Irradiation-Induced Hyposalivation

Unfolding the codes of short-term feed appetence in farm and companion animals. A comparative oronasal nutrient sensing biology review

Roles of innervation in developing and regenerating orofacial tissues

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