1997
DOI: 10.1006/excr.1996.3446
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Regulation of Ribosomal RNA Gene Transcription during Retinoic Acid-Induced Differentiation of Mouse Teratocarcinoma Cells

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Cited by 19 publications
(9 citation statements)
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“…7 These studies strongly suggest that the loss of UBF is causative in rDNA inactivation and demonstrate that pseudo-silencing occurs under biologically relevant conditions. As UBF expression decreases substantially during terminal differentiation in a wide range of systems, 61,[65][66][67][68][69] we propose that modulation of UBF is a general mechanism for rDNA silencing during development. It is worthy to note however that others have correlated changes in CpG methylation with certain models of differentiation 61 suggesting that both methylation dependent and independent mechanisms exist for rDNA inactivation during development.…”
Section: The Role Of Ubf In Regulation Of Active Gene Number During Dmentioning
confidence: 86%
“…7 These studies strongly suggest that the loss of UBF is causative in rDNA inactivation and demonstrate that pseudo-silencing occurs under biologically relevant conditions. As UBF expression decreases substantially during terminal differentiation in a wide range of systems, 61,[65][66][67][68][69] we propose that modulation of UBF is a general mechanism for rDNA silencing during development. It is worthy to note however that others have correlated changes in CpG methylation with certain models of differentiation 61 suggesting that both methylation dependent and independent mechanisms exist for rDNA inactivation during development.…”
Section: The Role Of Ubf In Regulation Of Active Gene Number During Dmentioning
confidence: 86%
“…During F9 cell differentiation induced by retinoic acid, rapidly growing teratocarcinoma cells are converted into various cell types. These cells display a low rate of proliferation and a downregulation of rDNA expression [26]. Cell growth in non-lymphoid cells stimulates ribosomal gene transcription [27].…”
Section: Discussionmentioning
confidence: 99%
“…The recent reports that IRS-1 can translocate to the nucleus and bind UBF1 (58, 62) provide a molecular explanation for the effect of IRS-1 on cell and body size. During differentiation (which is inhibited by IRS-1), an inhibition of RNA polymerase I activity (10,11,28,61) and a decrease in cell size (63) occur. In terminally differentiated cells, UBF1 is no longer detectable (11,61), and the nucleolus (which is the site of rRNA synthesis) involutes (50).…”
mentioning
confidence: 99%