Regulation of Retinol-binding Protein Metabolism by Vitamin A Status in the Rat

Muto, Yasutoshi; Smith, John E.; Milch, Peter O.; Goodman, DeWitt S.

doi:10.1016/s0021-9258(19)45460-4

Cited by 313 publications

(19 citation statements)

References 20 publications

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“…The dose-response tests work on the principle that RBP accumulates as vitamin A liver reserves become low. In rats that were fed a vitamin A-deficient diet, apo-RBP accumulated in the liver before serum retinol concentrations decreased, and the liver was depleted (32). Thus, when a challenge dose of retinyl or 3,4-didehydroretinyl ester is administered, the retinol or 3,4-didehydroretinol binds to this accumulated RBP and is rapidly released into the serum.…”

Section: Dose-response Testsmentioning

confidence: 99%

Vitamin A: biomarkers of nutrition for development

Tanumihardjo

2011

The American Journal of Clinical Nutrition

261

236

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Vitamin A is essential for multiple functions in mammals. Without vitamin A, mammals cannot grow, reproduce, or fight off disease. Because of its numerous functions in humans, biomarkers of vitamin A status are quite diverse. Assessment of liver reserves of vitamin A is considered the gold standard because the liver is the major storage organ. However, this measure is not feasible in human studies. Alternative biomarkers of status can be classified as biological, functional, histologic, and biochemical. Historically, signs of xerophthalmia were used to determine vitamin A deficiency. Before overt clinical damage to the eye, individuals who suffer from vitamin A deficiency are plagued by night blindness and longer vision-restoration times. These types of assessments require large population-based evaluations. Therefore, surrogate biochemical measures of vitamin A status, as defined by liver reserves, have been developed. Serum retinol concentrations are a common method used to evaluate vitamin A deficiency. Serum retinol concentrations are homeostatically controlled until liver reserves are dangerously low. Therefore, other biochemical methods that respond to liver reserves in the marginal category were developed. These included dose-response tests and isotope dilution assays. Dose-response tests work on the principle that apo-retinol-binding protein builds up in the liver as liver reserves become depleted. A challenge dose of vitamin A binds to this protein, and serum concentrations increase within a few hours if liver vitamin A concentrations are low. Isotope dilution assays use stable isotopes as tracers of total body reserves of vitamin A and evaluate a wide range of liver reserves. Resources available and study objectives often dictate the choice of a biomarker.

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Section: Dose-response Testsmentioning

confidence: 99%

Vitamin A: biomarkers of nutrition for development

Tanumihardjo

2011

The American Journal of Clinical Nutrition

261

236

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“…However, another two studies of patients admitted in intensive care unit found that low serum RBP4 levels were related to increased mortality in patients with acute exacerbations of chronic obstructive pulmonary disease and underlying liver disease, respectively. The decreased RBP4 levels might attribute to the malnutritional status in these critically ill patients, because circulating RBP4 concentration depends on vitamin A status . It was reported that severe calorie restriction could reduce the circulating and adipose tissue messenger ribonucleic acid expression of RBP4 .…”

Section: Discussionmentioning

confidence: 99%

Serum retinol‐binding protein 4 as a predictor of cardiovascular events in elderly patients with chronic heart failure

Zhang

Yan

et al. 2020

ESC Heart Failure

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Aims RBP4 is an adipokine with adverse effects on cardiovascular system. Increased circulating retinol-binding protein 4 (RBP4) has been linked to chronic heart failure (CHF). However, whether elevated RBP4 is correlated with a poor prognosis in elderly patients with CHF remains unclear. The aim of this study was to evaluate the prognostic value of serum RBP4 in elderly patients with CHF. Methods and results We enrolled 934 consecutive elderly patients (aged 60 years and older) with CHF and 138 age-matched and sex-matched control subjects in a prospective cohort study and explored the association of serum RBP4 levels with the clinical outcomes using multivariate Cox regression analyses. Serum RBP4 levels were elevated in CHF patients when compared with controls (46.66 ± 12.38 μg/mL vs. 40.71 ± 7.2 μg/mL, P < 0.001). Patients with the highest RBP4 concentrations had higher N terminal pro brain natriuretic peptide (NT-proBNP) levels but lower left ventricular eject fraction (LVEF) and estimated glomerular filtration rate (P < 0.001). Serum RBP4 levels were increased as the New York Heart Association functional class increased and LVEF decreased (P < 0.001) and were negatively correlated with LVEF (r = À0.154, P < 0.001) but positively correlated with NT-proBNP levels (r = 0.074, P = 0.023). Multivariate Cox regression analysis suggested that log RBP4 was an independent predictor for major adverse cardiac event(s) [hazard ratio (HR) = 2.61, 95% confidence interval (CI) = 1.19-5.70], together with age, male, LVEF, log NT-proBNP, and estimated glomerular filtration rate. Moreover, log RBP4 was also an independent predictor for cardiovascular mortality (HR = 2.24, 95% CI = 1. 35-5.39) and CHF rehospitalization (HR = 2.54, 95% CI = 1.09-5.60) even after adjustment for the established adverse prognostic factors for CHF. The Kaplan-Meier survival curves showed that high concentration of RBP4 was a prognostic indicator of major adverse cardiac event(s) in patients with CHF. Conclusions Our findings demonstrate for the first time that elevated serum RBP4 is correlated with worse outcome in elderly patients with CHF.

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“…Retinol/RBP (holo-RBP4) was the primary form of retinol in the blood, and its proportion reaches 99% under fasting condition [28]. Previous studies have shown that the levels of serum RBP in retinol-depleted rats was extremely low [29], after administration of retinol, holo-RBP was secreted immediately into the serum [30]. Under several pathophysiological conditions, decreased serum RBP4 levels were related to impaired synthesis and/or secretion of RBP4.…”

Section: Discussionmentioning

confidence: 99%

Retinol-binding protein 4 (RBP4) and high sensitivity C-reactive protein (hs-CRP) levels in patients with diminished ovarian reserve (DOR): a cross-sectional study

Zou

Wang

Xia

et al. 2020

Preprint

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Background: Antioxidant/oxidant imbalance has been reported to be related to diminished ovarian reserve (DOR). Vitamin A (retinol), a kind of antioxidant, plays a role in restoring ovarian oxidative damage, while C-reactive protein (CRP) is the classical marker of oxidative stress and has recently been identified as an independent variable that is associated with low anti-Mullerian hormone (AMH) levels in young women with DOR. Additionally, retinol binding protein 4 (RBP4) can be considered a substitute for retinol in healthy, nonobese women. The study aim was to determine the relationship between serum RBP4, high sensitivity C-reactive protein (hs-CRP) concentrations and ovarian reserve in nonobese DOR patients.Methods: This study included 24 DOR women and 48 normal ovarian reserve (NOR) women from the reproductive medical center of Renmin Hospital of Wuhan University. The serum RBP4 and high-sensitivity CRP (hs-CRP) levels were measured with ELISA kits.Results: RBP4 levels (20,648.36 ± 5475.16 ng/ml vs 23,986.48 ± 5995.64 ng/ml, p = 0.025) were decreased, and hs-CRP levels (695.08 ± 1090.19 ng/ml vs 364.32 ± 786.29 ng/ml, p = 0.012) were increased in the DOR group. Serum RBP4 was positively related to AMH (Pearson r = 0.518, p = 0.000), while hs-CRP was negatively correlated with AMH (Spearman r = -0.345, p = 0.005). after adjustments were made for the covariables, multiple line regression analysis showed that positive association between RBP4 and AMH still existed (β = 0.450, p ˂ 0.001).Conclusion: Decreased serum RBP4 levels and increased serum hs-CRP were observed in DOR patients in our study, and the strong correlation between RBP4 and AMH supports the notion that oxidative stress plays a role in DOR, and that appropriate levels of antioxidant vitamin A may be protective against ovarian reserve dysfunction.

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Regulation of Retinol-binding Protein Metabolism by Vitamin A Status in the Rat

Cited by 313 publications

References 20 publications

Vitamin A: biomarkers of nutrition for development

Vitamin A: biomarkers of nutrition for development

Serum retinol‐binding protein 4 as a predictor of cardiovascular events in elderly patients with chronic heart failure

Retinol-binding protein 4 (RBP4) and high sensitivity C-reactive protein (hs-CRP) levels in patients with diminished ovarian reserve (DOR): a cross-sectional study

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