Regulation of Relaxin Secretion and its Role in Pregnancy

Anderson, Lloyd L.

doi:10.1007/978-1-4684-5395-9_20

Cited by 26 publications

(9 citation statements)

References 205 publications

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“…Relaxin targets the cervix, myometrium, endometrium, and deciduas 22 and plays a critical role in suppressing uterine motility and remodeling connective tissue in preparation for parturition. 23 While its use in cervical ripening and induction of labor is ill defined, its pharmocologic potential is promising and further studies are warranted to elucidate its role in the induction process. 24 Corticotropin-releasing hormone (CRH) plays an enigmatic role in the regulation of and onset of labor.…”

Section: Overview Of the Hormonal Control Of Parturitionmentioning

confidence: 99%

Overview of the mechanisms of induction of labor

Irani

Foster

2015

Seminars in Perinatology

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Section: Overview Of the Hormonal Control Of Parturitionmentioning

confidence: 99%

Overview of the mechanisms of induction of labor

Irani

Foster

2015

Seminars in Perinatology

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“…Relaxin is produced in greatest concentrations by female reproductive tissues, particularly during pregnancy (Anderson, 1987;Sherwood, 1988). The corpus luteum of the pig is a rich source of this hormone (Anderson et ai, 1973), but small concentrations of biologically active relaxin, as measured by inhibition of uterine contractility and a radioimmunoassay for pig relaxin, were found in bovine corpora lutea and the circulating blood of cattle during late pregnancy (Fields et ai, 1980;Anderson et ai, 1982;Musah et ai, 1986bMusah et ai, , 1987aMusah et ai, , b, 1988.…”

Section: Introductionmentioning

confidence: 99%

“…Administration of relaxin by i.m. injection or into the cervical os induces marked changes in cervical dilatation; pelvic relaxation Musah et ai, 1986aMusah et ai, , b, 1988; separation of the pubic symphysis, with interpubic ligament formation (Schwabe et ai, 1978;Porter, 1979Porter, , 1984; and facilitation of parturition in animals of some species (MacLennan et ai, 1980;Evans et ai, 1983;Musah et ai, 1986a, b;Anderson, 1987). Relaxin is involved in luteolysis during late pregnancy in cattle, affecting peripheral blood concentrations of progesterone, oestrogen, oxytocin and prostaglandin (PG) F-2a (Musah et ai, 1986b(Musah et ai, , 1987a(Musah et ai, , b, 1989a.…”

Section: Introductionmentioning

confidence: 99%

Effect of relaxin on facilitation of parturition in dairy heifers

Bagna¹,

Schwabe²,

Anderson³

1991

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Summary. Purified 1R and C, respectively. The calving intervals were reduced in Groups 2R (P < 0\m=.\01) and 1R (P < 0\ m=. \ 05) compared with Group C. The incidence of dystocia was 29% (2 of 7) in Group 2R and 43% (3 of 7) in Group 1R compared with 57% (4 of 7) in Group C (P < 0\m=.\01).Body weights and ratios of males to females of the calves were similar (P > 0\m=.\05) between groups. Progesterone plasma concentrations decreased (P < 0\m=.\01) earlier in Groups IR and 2R compared with Group C, and this acute decrease began within 6 h of treatment. At 24 h after relaxin or PBS injection, progesterone concentrations were 2\m=.\7\m=+-\1\m=.\1 ng/ml for Group 2R, 3\m=.\5\ m=+-\0\m=.\9 ng/ml for Group 1R, and 6\m=.\0\ m=+-\0\m=.\1 ng/ml for Group C. Relaxin reached peak blood-plasma levels of 19 \ m=+-\ 2\m=.\2ng/ml 1h after injection of relaxin, but remained unchanged, 0\m=.\3\ m=+-\0\m=.\01 ng/ml, in Group C. Pelvic area was increased 26%, 22% and 14% and cervical dilatation was increased 109%, 76% and 53% 48 h after injection in Groups 2R, 1R and C, respectively, but these responses were similar among groups at the time of parturition. We conclude that two i.m. injections of relaxin facilitated earlier calving, acutely decreased progesterone secretion, increased cervical dilatation and pelvic area expansion, and decreased the incidence of dystocia in dairy heifers.

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“…Relaxin is a polypeptide hormone produced primarily during pregnancy, and is produced by various reproductive organs of many species (Anderson, 1987). Relaxin is involved in cervical dilatation (Downing & Sherwood, 1985), relaxation of the pubic symphysis (Steinetz et ai, 1960), inhibition of uterine contractility (Porter, 1971), and stimulation of uterine growth (Vasilenko & Mead, 1987).…”

Section: Introductionmentioning

confidence: 99%

Administration of pig relaxin to beef heifers 4 or 7 days pre partum

Caldwell

Bellows²,

Hall³

et al. 1990

Reproduction

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Summary. Crossbred beef heifers (N = 36) were assigned to one of three treatment groups: untreated controls (C; N = 15); Group R4, treated with pig relaxin (1\m=.\0mg i.m.) 4 days pre partum (N = 11); or Group R7, treated with pig relaxin ( 1 \ m=. \ 0 mg i.m.) 7 days pre partum (N = 10). Bioactivity of the pig relaxin (UMC-R-P8) was determined by the mouse interpubic ligament assay to be \ m=ge\ 3000 U/mg, both before and after the experiment was conducted. Peripheral serum immunoreactive relaxin values were 7\ m=. \ 5, 3\m=.\4,2\m=.\5, and 1\m=.\5, ng/ml at 2, 4, 6 and 8 h after injection of relaxin, respectively. Gestation lengths were 282\m=.\9\m=+-\1 \ m= . \ 1 285\m=.\5\ m=+-\1\m=.\3 and 285\m=.\6\ m=+-\1\ m=. \ 5days for Groups C, R4 and R7 (C vs R4 + R7; P \ m=si meq\ 0\m=.\08).Calving difficulty score (1 to 4) tended to be greater (P \ m=si meq\ 0\m=.\08) for Group R4 and R7 heifers (C vs R4 + R7; 1\m=.\3 \ m=+-\ 0\m=.\24vs 1\m=.\75 \ m=+-\ 0\m=.\28 + 2\m=.\04\m=+-\ 0\m=.\32), but the incidences of dystocia and retained placentae were not influenced by treatment (P \m=ge\ 0\m=.\10). The mean concentration and concentration profile of daily serum progesterone, oestradiol-17\g=b\,dihydroprostaglandin F-2\g=a\and relaxin were not affected by treatment from 6 days pre partum through 2 days post partum. Cervical diameter, cervical softness score, pelvic measurements, and vulva opening length during the periparturient period were not affected (P \m=ge\ 0\m=.\10)by treatment, but all of these characteristics changed over time (P \m=l e\ 0\m=.\01), relative to calving. We conclude that i.m. administration of pig relaxin (\m=ge\3000 U) does not effectively alter periparturient characteristics of beef heifers. Discrepancies between these results and those reported for intracervical administration cannot be readily explained.

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Regulation of Relaxin Secretion and its Role in Pregnancy

Cited by 26 publications

References 205 publications

Overview of the mechanisms of induction of labor

Overview of the mechanisms of induction of labor

Effect of relaxin on facilitation of parturition in dairy heifers

Administration of pig relaxin to beef heifers 4 or 7 days pre partum

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