Regulation of recovery in the erythroid lineage: model studies

Abstract

Abstract. Based on data from the literature, the major regulatory features were established for the erythroid population regenerating after perturbation. A mathematical model is proposed which takes into account: (1) the increase in the proliferating CFU‐S due to depopulation of CFU‐S and BFU‐E/8 pools due to increased migration caused by erythropoietin; (2) regeneration of erythroid precursors due to short‐range factors and (3) gradual reduction in the short‐range effects and increase in the humoral influence on BFU‐E/8, BFU‐E/3 and CFU‐E together with short‐range suppression of progenitor differentiation and acceleration of maturation in all subpopulations due to humoral factors. The kinetics of subpopulations as a function of feedback and maturation rate are analysed. The dependence of erythrocyte production on erythrocyte depletion in the blood and on the feedback coefficient is defined.