Regulation of rat gastric H+/K+-ATPase α-subunit mRNA by omeprazole

Role of Anti-Parietal Cell Antibody in Helicobacter pylori -associated Atrophic Gastritis: Evaluation in a Country of High Prevalence of Atrophic Gastritis

“…In addition, our present study demonstrated that APCA levels detected by ELISA remained unchanged after H. pylori eradication. Furthermore, levels of APCA detected by ELISA were unaffected by the long-term use of a proton-pum p inhibitor, which should induce H ‡ ,K ‡ -ATPase expression (32). APCAs detected by ELISA were not affected by acquired events such as H. pylori infection/eradication and long-term use of a proton-pum p inhibitor, suggesting APCA might be a congenital factor.…”

The effects of rabeprazole on parietal cells and enterochromaffin-like cells in rats: a comparison with omeprazole

“…10 In rats given a single oral dose of omeprazole (100 mg/kg), the H ϩ , K ϩ -ATPase activity was inhibited by 83% at 3 h and still remained low at 24h, while multiple doses of omeprazole caused profound inhibition of H ϩ , K ϩ -ATPase activity (Ϫ97%) at 6h. 8 Intragastric pH and H ϩ , K ϩ -ATPase activity recovered in a parallel manner after the last dose, and both returned to their pretreatment levels after 72h. The serum gastrin concentration was 5.1-fold and 5.3-fold higher than the control level at 12 h after a single dose and at 12h after four consecutive daily doses of omeprazole, respectively, and had returned to normal by 96 h after the fourth dose.…”

“…The serum gastrin concentration was 5.1-fold and 5.3-fold higher than the control level at 12 h after a single dose and at 12h after four consecutive daily doses of omeprazole, respectively, and had returned to normal by 96 h after the fourth dose. 8 On the other hand, in rats given oral rabeprazole (100 mg/kg), the serum gastrin concentration was 4.3-fold higher than the control level at 8 h after single and multiple doses, and had returned to the control level by 24h 18,19 personal communication from Dr. Yoshiji Miyazaki of the Second Department of Internal Medicine, Osaka University).…”

“…4-6 After inhibition by omeprazole, de-novo synthesis of the proton pump is thought to be necessary to restart acid secretion, 7 with full recovery taking 3 days in humans, dogs, and rats. 1,2,8 The rate of formation of the active compound is the main factor that determines the potency of these inhibitors in vitro, and the rate of formation of rabeprazole is higher than that of omeprazole. 9 When omeprazole and rabeprazole were given as single intraduodenal doses to dogs, the antisecretory activity of rabeprazole was slightly greater than that of omeprazole, although the duration of its activity was significantly shorter when the two drugs were compared at doses of 2 mg/kg and 4 mg/kg.…”

Effects of Ranitidine on Gastric Vesicles Containing H+, K+-Adenosine Triphosphatase in Rats

“…In vitro studies with isolated canine gastric parietal cells have demonstrated that mRNA levels of the H+,K+-ATPase asubunit increased transiently shortly after incubation with omeprazole (57). Tari et al (51,58) observed in rats that omeprazole treatment for up to 3 days stimulated the gene transcription of H+,K+-ATPase a-subunit. H+,K+-ATPase asubunit mRNA rose to a maximum of 95% above control 6 h after the last omeprazole dosage and returned to control levels after 36h.…”