Regulation of Pyroptosis by ncRNA: A Novel Research Direction

Gao, Liyuan; Jiang, Zhitao; Han, Yi; Li, Yang; Xiang, Yang

doi:10.3389/fcell.2022.840576

Cited by 14 publications

(12 citation statements)

References 129 publications

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“…The epigenetic regulation of pyroptosis may also depend on the action of small non-coding RNAs. It is known that several miRNAs bind to 3′-untranslated NLRP3 gene region and degrade it [104]. To confirm these evidences, it was demonstrated that during myeloid differentiation, low levels of miR-233 increases NLRP3 inflammasome transcription, accompanied by the release of pro-inflammatory cytokines in activated macrophages [105].…”

Section: Epigenetic Regulation In Pyroptosismentioning

confidence: 94%

Epi-Regulation of Cell Death in Cancer

Beato¹,

Torre²,

Capone³

et al. 2023

Biochemistry

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How do organisms regulate the correct balance between the production of “new” cells and the elimination of the “old” ones, remains an important biology issue under investigation. Cell(s) death represents a fundamental process involved in organism development and cell homeostasis, whose alteration is considered one hallmark of cancer and lead to drug resistance and consequently treatment failure. The recent re-classification of cell death has identified new molecular programs in which several proteins have a pivotal role. Several studies have highlighted a direct link between epigenetic modifications and cell death mechanisms. Different epi-modifications have been described, capable of regulating diverse key players implicated in cell death, leading to uncontrolled proliferation of cancer cells. Scientific efforts are focused on the understanding the epigenetic regulation of cell death mechanisms by developing tools and/or new epi-molecules able to overcome cell death resistance. The development of new epi-molecular tools can overcome cell death deregulation thus potentially improving the sensitivity to the anti-tumor therapies. This chapter focuses on the main epigenetic deregulations in cell death mechanisms in cancer.

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Section: Epigenetic Regulation In Pyroptosismentioning

confidence: 94%

Epi-Regulation of Cell Death in Cancer

Beato¹,

Torre²,

Capone³

et al. 2023

Biochemistry

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“…Other novel modes of cell death have recently been reported, including pyroptosis, necroptosis, and cytoproptosis. Although certain circRNAs (e.g., hsa_circ_0001836 [ 76 ], circNEIL3 [ 77 ], and has_circ_0007312 [ 78 ]) have been found to promote pyroptosis in some cancers, the role of circRNA-mediated pyroptosis in thyroid cancers remains largely unknown. While necropoptosis has been reported in TCs [ 79 ], studies on the circRNA-mediated progression of TC through necroptosis are still lacking.…”

Section: Circrnas and Their Roles In Regulating Tc Hallmarksmentioning

confidence: 99%

Emerging roles of circular RNAs in regulating the hallmarks of thyroid cancer

Zhou,

Li,

Jiang

et al. 2024

Cancer Gene Ther

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Thyroid cancer is a prevalent endocrine malignancy with increasing incidence in recent years. Although most thyroid cancers grow slowly, they can become refractory, leading to a high mortality rate once they exhibit recurrence, metastasis, resistance to radioiodine therapy, or a lack of differentiation. However, the mechanisms underlying these malignant characteristics remain unclear. Circular RNAs, a type of closed-loop non-coding RNAs, play multiple roles in cancer. Several studies have demonstrated that circular RNAs significantly influence the development of thyroid cancers. In this review, we summarize the circular RNAs identified in thyroid cancers over the past decade according to the hallmarks of cancer. We found that eight of the 14 hallmarks of thyroid cancers are regulated by circular RNAs, whereas the other six have not been reported to be correlated with circular RNAs. This review is expected to help us better understand the roles of circular RNAs in thyroid cancers and accelerate research on the mechanisms and cure strategies for thyroid cancers.

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“…Reports indicate that miR-22 mediates neuroinflammatory cascades and cell death through pyroptosis [ 82 , 83 ]. Low levels of miR-22 in the peripheral blood of AD patients suggests that mimicking miR-22 function could aid in the reduction of pyroptosis.…”

Section: Mechanisms Of Mirnas In Dementia-related Diseasementioning

confidence: 99%

MicroRNA Networks in Cognition and Dementia

Blount

Coursey

Kocerha

2022

Cells

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The change from viewing noncoding RNA as “junk” in the genome to seeing it as a critical epigenetic regulator in almost every human condition or disease has forced a paradigm shift in biomedical and clinical research. Small and long noncoding RNA transcripts are now routinely evaluated as putative diagnostic or therapeutic agents. A prominent role for noncoding microRNAs in the central nervous system has uncovered promising new clinical candidates for dementia-related disorders, treatments for which currently remain elusive even as the percentage of diagnosed patients increases significantly. Cognitive decline is a core neurodegenerative process in Alzheimer’s Disease, Frontotemporal Dementia, Lewy body dementia, vascular dementia, Huntington’s Disease, Creutzfeldt–Jakob disease, and a significant portion of Parkinson’s Disease patients. This review will discuss the microRNA-associated networks which influence these pathologies, including inflammatory and viral-mediated pathways (such as the novel SARS-CoV-2 virus implicated in COVID-19), and their current status in clinical trials.

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Regulation of Pyroptosis by ncRNA: A Novel Research Direction

Cited by 14 publications

References 129 publications

Epi-Regulation of Cell Death in Cancer

Epi-Regulation of Cell Death in Cancer

Emerging roles of circular RNAs in regulating the hallmarks of thyroid cancer

MicroRNA Networks in Cognition and Dementia

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