“…These results are in accordance with the previous studies. 19 , 20 Moreover, we also observed dose-dependent effects of HA on the promotion of cell death as demonstrated by increased Annexin V + cells and caspase-3/7 activity ( Figures 1 G, 1H, S1 H, and S1I). We also observed a dose-dependent decrease in cell proliferation by EdU assay ( Figures 1 I and S1 J), and the accumulation of DNA fragmentation by TUNEL assay ( Figures 1 J and S1 K).…”