Regulation of Protein Synthesis in Heart Muscle

Acute effects of simultaneous intraperitoneal infusion of glucose and amino acids

“…In addition, AAs have been shown to stimulate protein synthesis In our study, both stimulatory effects were present. The insulin levels were already high at the beginning of directly in muscle [39] and suppress proteolysis in perfused rat liver [40]. Thus, both insulin and AA can di-APD because of the postprandial increase and returned to normal only three hours after the beginning of APD.…”

Nonuniform Rates of Turnover of Myofibrillar Proteins in Rat Diaphragm

“…Another possible explanation of these apparently contradictory observations would be that the present results hold only for tissues incubated in vitro. During incubation in vitro, both skeletal muscle (R. M. Fulks and A. L. Goldberg, in preparation) and cardiac muscle (27,28) generally undergo net protein degradation, which only occurs in the organism during such conditions as starvation or muscle atrophy (30). Possibly the in vitro incubation also alters the pattern of protein synthesis, such that the various contractile proteins are produced nonuniformly.…”