Regulation of protein phosphorylation by triiodothyronine (T3) in neural cell cultures. Part I: Astrocytes

Ruel, Jean; Gavaret, Jean‐Michel; Luo, Min; Dussault, Jean H.

doi:10.1016/0303-7207(86)90151-6

Cited by 16 publications

(4 citation statements)

References 38 publications

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“…The addition of trriodothyronine alone had a much smaller effect on enzyme activity and enzyme synthesis than on mRNA concentration (Fischer and Goodridge, 1978; . The same result was obtained with malic enzyme Triiodothyronine is reported to stimulate protein kinase activity or phosphorylation of nuclear proteins (Nikodem et aL, 1977;Ruel et al, 1986 …”

supporting

confidence: 71%

Structure and regulation of the avian gene for fatty acid synthase

Goodridge¹,

Carpenter²,

Goldman³

et al. 1989

Reprod. Nutr. Dévelop.

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supporting

confidence: 71%

Structure and regulation of the avian gene for fatty acid synthase

Goodridge¹,

Carpenter²,

Goldman³

et al. 1989

Reprod. Nutr. Dévelop.

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“…Phosphorylation of the nonhistone proteins HhlC14 and 1' 7 may play a role in modification of transcriptionally active ~h r o r n a t i n .~ Thyroid hormone stimulation of glial cell cultures has been shown to result in phosphoprotein of HMG14. 15 Further, phosphorylation can also regulate gate expression at the translational ieve1.337…”

mentioning

confidence: 99%

Effect of neural activity on skeletal muscle phosphoproteins

1990

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A number of phosphoproteins were found in the soluble fraction of rat skeletal muscle by two-dimensional polyacrylamide gel electrophoresis (PAGE). The pattern of some of these phosphoproteins differed in fast (extensor digitorum longus, EDL) or slow (soleus) muscles, was dependent on normal innervation, and was altered with denervation. In order to determine if the pattern was maintained by electrical activity or trophic factors, we compared the effect of electrical block by local neural application of tetrodotoxin with the effect of complete nerve section. Both methods produced similar alterations in phosphoproteins, indicating that the pattern is dependent on nerve activity, not trophic factors. Such phosphoproteins are possible mediators of neural activity on gene expression.

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“…In vivo, neonatal hypothyroidism results in an increased number of astrocytes and Bergmann glia in the rat cerebellum and hyperthyroidism produces the opposite effect (Clos & Legrand 1973). In vitro, thyroid hormone has been reported to affect astrocyte morphology, GFAP organization and glutamine synthetase activity and expression (Aizenman & de Vellis 1987, Gavaret et al 1991, Trentin & Moura Neto 1995, Trentin et al 1995, Lima et al 1997, Calloni et al 2001 in addition to the regulation of protein phosphorylation (Ruel et al 1986) and glucose transporter (Roeder et al 1985, 1988, Ruel & Dussault 1985. In astrocytes, thyroid hormone is also involved in the regulation of extracellular matrix organization, growth factor secretion, and cell proliferation (Trentin & Moura Neto 1995, Trentin et al 1995, 2001, Lima et al 1997, Farwell & Dubord-Tomasetti 1999b, Martinez & Gomes 2002.…”

Section: Thyroid Hormone Promotes Astrocyte Differentiationmentioning

confidence: 99%

Thyroid hormone and astrocyte morphogenesis

Trentin¹

2006

Journal of Endocrinology

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Astrocyte cells clearly play a role in neural development, but nowadays their total action is seen as a far wider one. Recent findings consider them as stem cells, involved in the control of most facets of functional neural networks. Astrocytes play a central role in thyroid hormone metabolism in the brain, being the principal transporters of thyroxine from the blood, responsible for its conversion to 3,5,3 -triiodothyronine and hence supplying the neural tissues with the biologically active form of the hormone. Specific thyroid hormone transporters play an essential role in this regulatory system. The presence of thyroid hormone receptors has been demonstrated in cultured astrocytes. Furthermore, thyroid hormone regulates several aspects of astrocyte differentiation and maturation, including the production of extracellular matrix proteins and growth factors, and thus controls neuronal growth and neuritogenesis. Therefore, astrocytes are currently suggested as important mediators of thyroid hormone in neuronal development.

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Regulation of protein phosphorylation by triiodothyronine (T3) in neural cell cultures. Part I: Astrocytes

Cited by 16 publications

References 38 publications

Structure and regulation of the avian gene for fatty acid synthase

Structure and regulation of the avian gene for fatty acid synthase

Effect of neural activity on skeletal muscle phosphoproteins

Thyroid hormone and astrocyte morphogenesis

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