Regulation of Presynaptic Terminal Organization by C. elegans RPM-1, a Putative Guanine Nucleotide Exchanger with a RING-H2 Finger Domain

Abstract

NMJs, the membrane-associated guanylate kinases (MAGUK), such as the vertebrate PSD-95/SAP90 (Cho et al., 1992; Kistner et al., 1993) and Drosophila Discslarge (DLG) (Woods and Bryant, 1991), are implicated in organizing the postsynaptic density (PSD) (for review,

GABA Is Dispensable for the Formation of Junctional GABA Receptor Clusters inCaenorhabditis elegans

“…Interestingly, proteins of the presynaptic active zone are properly localized in unc-104 mutants. Specifically, liprin/ SYD-2 (Zhen and Jin, 1999), Rab-3 interacting molecule/ UNC-10 ( Koushika et al, 2001), and RPM-1 (Schaefer et al, 2000;Zhen et al, 2000) are correctly localized in the dorsal cord; however, these incomplete synapses cannot direct the clustering of GABA receptors. Therefore, sites of presynaptic differentiation can be specified in the motor neuron independently from the formation of synaptic vesicle aggregates.…”

Defining Minimal Binding Regions in Regulator of Presynaptic Morphology 1 (RPM-1) Using Caenorhabditis elegans Neurons Reveals Differential Signaling Complexes

“…The PHR proteins regulate various events in neuronal development, including synapse formation (3)(4)(5)(6), axon guidance (6 -9), and axon termination (7, 10 -13). In C. elegans, defects in neuronal development caused by loss of RPM-1 result in mild defects in locomotion and severe defects in short-term learning (14).…”

UNC-64 and RIC-4, the plasma membrane-associated SNAREs syntaxin and SNAP-25, regulate fat storage in nematode Caenorhabditis elegans

“…As shown in Fig. 6A NMJs disappear [20,21] . F-box SyNaptic protein (FSN-1) is physically associated with RPM-1 and the homologues of SKP1 and Cullins to form a new type of SCF complex (Skp-1, Cullin and an F-box protein) at presynaptic periactive zones.…”