Regulation of post-translational modification in breast cancer treatment

Heo, Kyung‐Sun

doi:10.5483/bmbrep.2019.52.2.017

Cited by 36 publications

(27 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SENP2 have not been reported in UCEC related research. However, it may play a crucial role in hypoxia-induced lung cancer progression [24] and diagnosis or therapeutic targets for breast cancer treatment [25]. TBCCD1, a key regulator of centrosome positioning and consequently of internal cell organization, is a new centrosomal protein [26], and it has not been mentioned in any cancer.…”

Section: Discussionmentioning

confidence: 99%

Alteration of tumor associated neutrophils by PIK3CA expression in endometrial carcinoma from TCGA data

Pan

Liu

et al. 2019

J Ovarian Res

View full text Add to dashboard Cite

Uterine corpus endometrial carcinoma (UCEC) is one of the most common cancer in female worldwide. PIK3CA has been proven to be a strong prognostic biomarker in UCEC. Nevertheless, current studies have not investigated what effects PIK3CA had on tumor associated neutrophils (TANss). Kaplan-Meier methods were used to compute the survival time of TCGA UCEC patients. GO and KEGG enrichment analysis unveiled relevant pathways PIK3CA affected using DEGs between PIK3CA high expression group and PIK3CA low expression group in TCGA UCEC, as well as GSEA. immune infiltration status was calculated using TIMER. We found that PIK3CA influenced a number of pathways including immune related pathways. The fraction of TANs was certainly altered by PIK3CA expression in UCEC. Our findings suggest that PIK3CA expression may play an important role in tumor immune microenvironment and could alter fraction of TANs in UCEC. Electronic supplementary material The online version of this article (10.1186/s13048-019-0557-6) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Alteration of tumor associated neutrophils by PIK3CA expression in endometrial carcinoma from TCGA data

Pan

Liu

et al. 2019

J Ovarian Res

View full text Add to dashboard Cite

show abstract

“…PTMs are involved in various physiological and pathological processes including cancers due to countless targeted proteins. Therefore, proteins possessing PTMs capacity have always been deemed as potential and promising therapeutic targets for cancer treatment [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

USP4 function and multifaceted roles in cancer: a possible and potential therapeutic target

et al. 2020

View full text Add to dashboard Cite

Cancer remains one of the major culprits causing disease-related deaths and leads to a high morbidity and similar mortality. Insidious onset, difficult early detection and a lack of broad-spectrum and effective multi-cancer therapeutic targets have limited the prolongation of cancer patients’ survival for decades. Therefore, a versatile therapeutic target which is involved in various cancer-related signaling pathways and different cancers may be more effective for cancer targeted therapy. USP4, one of the DUBs members which participates in deubiquitination, an inverse process of ubiquitination, can regulate various classical cancer-related signaling pathways, and thereby plays a vital role in some pathological and physiological processes including tumor initiation and progression. Recently, USP4 has been found to exert versatile influences on cells proliferation, migration and invasion, also apoptosis of various tumors. Moreover, USP4 can also act as a prognostic biomarker in several cancers. This review will give a comprehensive introduction of USP4 about its regulatory mechanisms, related signaling pathways, pathophysiological functions and the roles in various cancers which may help us better understand its biological functions and improve future studies to construct suitable USP4-targeted cancer therapy system.

show abstract

“…Breast cancer is the most commonly occurring cancer in women and one of the leading causes of death in women after menopause [ 1 ]. Breast cancer can be classified according to three cellular markers: (i) progesterone receptor (PR) or estrogen receptor (ER) positive, (ii) human epidermal growth factor receptor-2 (HER2) positive, and PR and/or ER positive or negative, and (iii) triple negative breast cancer (TNBC) [ 2 , 3 , 4 ]. In particular, TNBC refers to tumors without the expression of PR, ER, and HER2, and is associated with a more frequent relapse and higher mortality than the different types of breast cancer [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA 34a–AXL Axis Regulates Vasculogenic Mimicry Formation in Breast Cancer Cells

Lim

Cho

Yun

et al. 2020

Genes

View full text Add to dashboard Cite

Targeting the tumor vasculature is an attractive strategy for cancer treatment. However, the tumor vasculature is heterogeneous, and the mechanisms involved in the neovascularization of tumors are highly complex. Vasculogenic mimicry (VM) refers to the formation of vessel-like structures by tumor cells, which can contribute to tumor neovascularization, and is closely related to metastasis and a poor prognosis. Here, we report a novel function of AXL receptor tyrosine kinase (AXL) in the regulation of VM formation in breast cancer cells. MDA-MB-231 cells exhibited VM formation on Matrigel cultures, whereas MCF-7 cells did not. Moreover, AXL expression was positively correlated with VM formation. Pharmacological inhibition or AXL knockdown strongly suppressed VM formation in MDA-MB-231 cells, whereas the overexpression of AXL in MCF-7 cells promoted VM formation. In addition, AXL knockdown regulated epithelial–mesenchymal transition (EMT) features, increasing cell invasion and migration in MDA-MB-231 cells. Finally, the overexpression of microRNA-34a (miR-34a), which is a well-described EMT-inhibiting miRNA and targets AXL, inhibited VM formation, migration, and invasion in MDA-MB 231 cells. These results identify a miR-34a–AXL axis that is critical for the regulation of VM formation and may serve as a therapeutic target to inhibit tumor neovascularization.

show abstract

Regulation of post-translational modification in breast cancer treatment

Cited by 36 publications

References 64 publications

Alteration of tumor associated neutrophils by PIK3CA expression in endometrial carcinoma from TCGA data

Alteration of tumor associated neutrophils by PIK3CA expression in endometrial carcinoma from TCGA data

USP4 function and multifaceted roles in cancer: a possible and potential therapeutic target

MicroRNA 34a–AXL Axis Regulates Vasculogenic Mimicry Formation in Breast Cancer Cells

Contact Info

Product

Resources

About