Regulation of optimized new Shengmai powder on cardiomyocyte apoptosis and ferroptosis in ischemic heart failure rats: The mediating role of phosphatidylinositol-3-kinase/protein kinase B/tumor protein 53 signaling pathway

Zhang, Ze-Yu; Yang, Zhi-Hua; Wang, Shuai; Feng, Shao-Ling; Wang, Xian-Liang; Mao, Jing-Yuan

doi:10.1016/j.jep.2024.118264

Cited by 1 publication

(1 citation statement)

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“…The tumor suppressor p53, which is activated by various stress signals, has been implicated in regulating ferroptosis ( 58 ). By repressing the SLC7A11 gene at the transcriptional level, p53 contributes to the onset of ferroptosis by hindering the uptake of cysteine, an essential amino acid for GSH synthesis, thereby promoting ferroptosis ( 54 ).…”

Section: Characteristics Of Ferroptosismentioning

confidence: 99%

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Yang,

Lin,

Han

et al. 2024

Front. Immunol.

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Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation and differs from programmed cell death, such as apoptosis, necrosis, and autophagy. Ferroptosis is associated with a variety of physiological and pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence and development of diseases by targeting metabolic pathways and signaling pathways in tumors, ischemic organ damage, and other degenerative diseases related to lipid peroxidation. Increasing evidence suggests that ferroptosis is closely linked to the onset and progression of various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinoblastoma. Our review of the current research on ferroptosis in ophthalmic diseases reveals significant advancements in our understanding of the pathogenesis, aetiology, and treatment of these conditions.

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Section: Characteristics Of Ferroptosismentioning

confidence: 99%