Regulation of oestrogen-induced LH release in male and female marmoset monkeys (Callithrix jacchus)

Hodges, J. K.

doi:10.1530/jrf.0.0600389

Cited by 13 publications

(6 citation statements)

References 23 publications

(28 reference statements)

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“…In the intact adult male, the majority of the animals demonstrated an initial decrease and then increase in LH levels after estradiol administration. The maximal levels of LH were relatively lower and achieved later (28–36 hr), compared to the castrated marmosets (Hodges and Hearn, 1978; Hodges, 1980). Nevertheless, the existence of a clear positive feedback response to estradiol injection in an intact normal male seems to be unique to the marmoset.…”

Section: Testicular Developmentmentioning

confidence: 82%

Review on testicular development, structure, function, and regulation in common marmoset

Donald

Golub

2005

Birth Defect Res B

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It seems that the endocrine system including the testis in marmosets has some unique features that have not been observed in rodents, Old World primates, and humans, but detailed comparison in these features among these species will be presented in another review. Based on the data available, marmoset seems to be an interesting model for comparative studies. However, interpretation of experimental findings on the testicular effects in marmosets should be made with serious caution. Depending on potential mode of testicular actions of the chemical under investigation, marmoset may have very limited value in predicting potential testicular or steroid hormone-related endocrine effects of test chemicals in humans.

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Section: Testicular Developmentmentioning

confidence: 82%

Review on testicular development, structure, function, and regulation in common marmoset

Donald

Golub

2005

Birth Defect Res B

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“…Differentiation is certainly present in rodents (Butcher et al, 1974 ; Kalra and Kalra, 1983 ); however, in primates, the sexual differentiation of the pituitary function related to gonadotropin secretion is different from that in rodents (Karsch et al, 1973 ). Luteinizing hormone induction due to positive feedback from estrogen is evident in female, but not male, rodents (Kalra, 1993 ); although, in primates, both sexes secrete luteinizing hormone in response to estrogen (Karsch et al, 1973 ; Hodges, 1980 ). Estrogen positive feedback is capable of inducing luteinizing hormone secretion even in castrated human males, suggesting that exposure of the human brain to androgen during the early perinatal period does not completely induce a sexually dimorphic mechanism for controlling gonadotropin secretion (Barbarino and De Marinis, 1980 ).…”

Section: Sexual Differentiation Of the Hypothalamus: Rodents And Primmentioning

confidence: 99%

Sex differences in feeding behavior in rats: the relationship with neuronal activation in the hypothalamus

et al. 2015

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There is general agreement that the central nervous system in rodents differs between sexes due to the presence of gonadal steroid hormone during differentiation. Sex differences in feeding seem to occur among species, and responses to fasting (i.e., starvation), gonadal steroids (i.e., testosterone and estradiol), and diet (i.e., western-style diet) vary significantly between sexes. The hypothalamus is the center for controlling feeding behavior. We examined the activation of feeding-related peptides in neurons in the hypothalamus. Phosphorylation of cyclic AMP response element-binding protein (CREB) is a good marker for neural activation, as is the Fos antigen. Therefore, we predicted that sex differences in the activity of melanin-concentrating hormone (MCH) neurons would be associated with feeding behavior. We determined the response of MCH neurons to glucose in the lateral hypothalamic area (LHA) and our results suggested MCH neurons play an important role in sex differences in feeding behavior. In addition, fasting increased the number of orexin neurons harboring phosphorylated CREB in female rats (regardless of the estrous day), but not male rats. Glucose injection decreased the number of these neurons with phosphorylated CREB in fasted female rats. Finally, under normal spontaneous food intake, MCH neurons, but not orexin neurons, expressed phosphorylated CREB. These sex differences in response to fasting and glucose, as well as under normal conditions, suggest a vulnerability to metabolic challenges in females.

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“…In the second application, we evaluate the gonadotropin response to estrogen injection in male lion tamarins. In male common marmosets, an estrogen challenge yields significant elevations in plasma LH after an initial suppression [positive feedback, Hodges, 1980;Hodges & Hearn, 19783, while in other species only negative feedback (reduced gonadotropin concentrations) is noted after estrogen stimulation in intact males [Karsh et al, 1973;Westfahl et al, 19841. We wished to evaluate which pattern is expressed by male lion tamarins.…”

Section: Mone Negative Feedback Ovulation Detectionmentioning

confidence: 99%

Urinary and plasma gonadotropin concentrations in golden lion tamarins (Leontopithecus r. rosalia)

French¹,

deGraw

Hendricks

et al. 1992

American J Primatol

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This paper describes the development and validation of a plasma and urinary gonadotropin immunoassay for golden lion tamarins (Leontopithecus rosalia), an endangered New World callitrichid primate. The assay is derived from a macaque chorionic gonadotropin assay and was validated for both plasma and urine samples in L. rosalia. Levels of immunoreactive LHiCG in lion tamarin urine were highly correlated ( r = + 0.98) with gonadotropin bioactivity. Immunoreactive LHiCG levels were examined in two contexts: in the urine of adult females and in the plasma of adult males after administration of estrogen. Peaks of gonadotropin excretion were detected in samples collected from nonpregnant adult females. The peaks occurred immediately prior to cyclic elevations in urinary estrogen excretion. Plasma LHiCG concentration in males measured 24 and 48 hours after a single 50 pg injection of estradiol benzoate were significantly lower than levels at these time points measured after control treatment. Together, the results of this study point to the utility of the gonadotropin assay for monitoring reproductive function in both female and male lion tamarins.

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Regulation of oestrogen-induced LH release in male and female marmoset monkeys (Callithrix jacchus)

Cited by 13 publications

References 23 publications

Review on testicular development, structure, function, and regulation in common marmoset

Review on testicular development, structure, function, and regulation in common marmoset

Sex differences in feeding behavior in rats: the relationship with neuronal activation in the hypothalamus

Urinary and plasma gonadotropin concentrations in golden lion tamarins (Leontopithecus r. rosalia)

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