Regulation of Nuclear Factor κB in the Hippocampus by Group I Metabotropic Glutamate Receptors

O’Riordan, Kenneth J.; Huang, I-Chia; Pizzi, Marina; Spano, PierFranco; Boroni, F.; Egli, Regula E.; Desai, Priyanka; Fitch, Olivia; Malone, Lauren; Ahn, Hyung Jin; Liou, Hsiou‐Chi; Sweatt, J. David; Levenson, Jonathan M.

doi:10.1523/jneurosci.4527-05.2006

Cited by 100 publications

(102 citation statements)

References 66 publications

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“…The apparatus consisted of two compartments, one light and the other dark, separated by a vertical sliding door (O'Riordan et al, 2006). We initially placed a mouse in the light compartment for 20 s. After the door was opened, the mouse could enter the dark compartment (mice instinctively prefer being in the dark).…”

Section: Passive Avoidance Learningmentioning

confidence: 99%

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Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice

Nagata

Nakashima-Kamimura

Mikami

et al. 2008

Neuropsychopharmacol

227

182

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We have reported that hydrogen (H 2 ) acts as an efficient antioxidant by gaseous rapid diffusion. When water saturated with hydrogen (hydrogen water) was placed into the stomach of a rat, hydrogen was detected at several mM level in blood. Because hydrogen gas is unsuitable for continuous consumption, we investigated using mice whether drinking hydrogen water ad libitum, instead of inhaling hydrogen gas, prevents cognitive impairment by reducing oxidative stress. Chronic physical restraint stress to mice enhanced levels of oxidative stress markers, malondialdehyde and 4-hydroxy-2-nonenal, in the brain, and impaired learning and memory, as judged by three different methods: passive avoidance learning, object recognition task, and the Morris water maze. Consumption of hydrogen water ad libitum throughout the whole period suppressed the increase in the oxidative stress markers and prevented cognitive impairment, as judged by all three methods, whereas hydrogen water did not improve cognitive ability when no stress was provided. Neural proliferation in the dentate gyrus of the hippocampus was suppressed by restraint stress, as observed by 5-bromo-2 0 -deoxyuridine incorporation and Ki-67 immunostaining, proliferation markers. The consumption of hydrogen water ameliorated the reduced proliferation although the mechanistic link between the hydrogen-dependent changes in neurogenesis and cognitive impairments remains unclear. Thus, continuous consumption of hydrogen water reduces oxidative stress in the brain, and prevents the stress-induced decline in learning and memory caused by chronic physical restraint. Hydrogen water may be applicable for preventive use in cognitive or other neuronal disorders.

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Section: Passive Avoidance Learningmentioning

confidence: 99%

“…We examined learning and memory ability using the passive avoidance test (O'Riordan et al, 2006). Mice instinctively prefer a dark compartment; however, if an electric shock is given in the dark compartment, the mice are normally reluctant to reenter it.…”

Section: Passive Avoidance Learning Novel Recognition Test and Morrmentioning

confidence: 99%

Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice

Nagata

Nakashima-Kamimura

Mikami

et al. 2008

Neuropsychopharmacol

227

182

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“…Furthermore, learning enhances the expression of genes containing NF-κB regulatory elements, supporting a role for NF-ΚB -mediated transcriptional regulation in cognitive function (Levenson, et al, 2004;O'Sullivan, et al, 2007). The presence of certain NF-κB subunits has been characterized as a determinant in regulating CNS development and in synaptic plasticity, learning and memory, specifically implicating the p50, RelA/p65 and cRel subunits (Ahn, et al, 2008;Kaltschmidt, et al, 2006;Meffert & Baltimore, 2005;O'Riordan, et al, 2006). In addition, NF-κB subunit composition, particularly the p65:p50 heterodimer is activated by excitatory stimulation at hippocampal synapses (Kaltschmidt, et al, 1993;Meffert, et al, 2003;Suzuki, et al, 1997), a region key to learning and memory.…”

Section: Cc2d1a-mediated Nf-κb Activationmentioning

confidence: 95%

The Freud-1/CC2D1A Family: Multifunctional Regulators Implicated in Mental Retardation

Millar¹,

Souslova²,

Albert³

2012

Latest Findings in Intellectual and Developmental Disabilities Research

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“…The GR binds to and inactivates other transcription factors, such as nuclear factor kappa beta and AP-1, and thus exerts an anti-inflammatory response. [18][19][20][21] This activation and translocation process and subsequent GR-mediated gene transcription is regulated by heat shock proteins 70 and 90 and their cochaperones, such as FK506 binding protein 51 (FKBP5) and BCL2 associated athanogene.…”

mentioning

confidence: 99%

Role of corticosteroids in the antidepressant response

Pierscionek¹,

Adekunte²,

Watson³

et al. 2014

CPT

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Anything that engenders a homeostatic response in the tightly regulated hypothalamic-pituitary-adrenal (HPA) axis may be thought of as a stressor and may exert an allostatic load, engendering a sustained change in the regulation of this system. Genetic, epigenetic, endocrine, post mortem, and animal studies suggest that dysregulation of the HPA axis plays a part in the pathophysiology of mood disorders and negatively impacts the antidepressant response and prognosis. Neuropsychological impairment, which is a common and disabling concomitant of depression, has been linked to disturbance of the HPA axis. A number of HPA axis-mediated treatment strategies have shown benefit in open or smallscale preliminary trials, and there are ongoing studies seeking both to replicate these initial findings and to develop new targets. HPA axis-based treatments are a fertile area of research, and much current thought pertains to the optimum targets, optimum population (including the potential for stratified medicine), and optimum outcome measures. We have, for instance, argued here that neuropsychological performance may be more sensitive and robust than scores on traditional depression rating scales.

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Regulation of Nuclear Factor κB in the Hippocampus by Group I Metabotropic Glutamate Receptors

Cited by 100 publications

References 66 publications

Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice

Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice

The Freud-1/CC2D1A Family: Multifunctional Regulators Implicated in Mental Retardation

Role of corticosteroids in the antidepressant response

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