Abstract:28The Glucocorticoid Receptor (GR) co-ordinates metabolic and behavioural 29 responses to stressors. We hypothesised that GR influences behaviour by 30 modulating specific epigenetic and transcriptional processes in the brain. Using the 31 zebrafish as a model organism, the brain methylomes of wild-type and gr s357 mutant 32 adults were analysed and GR-sensitive, differentially methylated regions (GR-DMRs) 33 were identified. Two genes with GR-DMRs exhibited distinct methylation and 34 transcriptional sensitiv… Show more
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