Regulation of naïve and memory T-cell homeostasis

Surh, Charles D.; Sprent, Jonathan

doi:10.1016/s1286-4579(01)01509-x

Cited by 69 publications

(66 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fraction of dividing cells in the various T cell subsets did not differ between tg and wt mice. Increased overall turnover in T cells from tg mice was thus due to the increased proportion of E/M cells, which have a larger fraction of dividing cells compared with the naive T cell subset (data not shown) (26,28).…”

Section: Increased T Cell Turnover In Nef Tg Micementioning

confidence: 96%

“…Ag-inexperienced naive T cells can be distinguished from Ag-experienced effector and memory T cells on basis of their CD62L and CD44 expression levels. Although T cells expressing CD44 medium CD62L high are defined as naive, CD44 high CD62L low and CD44 high CD62L high are defined as effector/memory (E/M/) cells (25)(26)(27).…”

Section: Strongly Reduced T Cell Numbers and A Highly Activated T Celmentioning

confidence: 99%

See 1 more Smart Citation

T Cell Activation and Proliferation Characteristic for HIV-Nef Transgenic Mice Is Lymphopenia Induced

Koenen

Hofhuis

Oosterwegel

et al. 2007

The Journal of Immunology

View full text Add to dashboard Cite

The HIV-Nef protein has been implicated in generating high viral loads and T cell activation. Transgenic (tg) mice with constitutive T cell-specific Nef expression show a dramatic reduction in T cell number and highly increased T cell turnover. Previous studies in Nef tg mice attributed this T cell activation to a direct effect of Nef at the cellular level. Given the strongly reduced peripheral T cell numbers, we examined whether this enhanced T cell division might instead be lymphopenia induced. Adoptively transferred naive wild-type T cells into lymphopenic Nef tg mice showed high T cell turnover and obtained the same effector/memory phenotype as the autologous Nef tg T cells, supporting the idea that the microenvironment determines the phenotype of the T cells present. Moreover, in bone marrow chimeras from mixtures of wild-type and Nef tg bone marrow, with a full T cell compartment containing a small proportion of Nef tg T cells, Nef tg T cells kept a naive phenotype. These results demonstrate that T cell activation in the Nef tg mice is lymphopenia induced rather than due to a direct T cell-activating effect of Nef.

show abstract

Section: Increased T Cell Turnover In Nef Tg Micementioning

confidence: 96%

Section: Strongly Reduced T Cell Numbers and A Highly Activated T Celmentioning

confidence: 99%

T Cell Activation and Proliferation Characteristic for HIV-Nef Transgenic Mice Is Lymphopenia Induced

Koenen

Hofhuis

Oosterwegel

et al. 2007

The Journal of Immunology

View full text Add to dashboard Cite

show abstract

“…Several studies, primarily focusing on ␣␤ T cells, have recently provided molecular and cellular explanations of lymphocyte homeostasis regulation (reviewed in Refs. [7][8][9][10][11]. Under lymphocyte-sufficient conditions, survival (without proliferation) of naive CD4 ϩ and CD8 ϩ T cells depends on at least two independent signals, i.e., TCR interaction with self-peptide/MHC ligands and availability of IL-7.…”

Section: ␥␦ T Cell Homeostasis Is Controlled By Il-7 and Il-15mentioning

confidence: 99%

γδ T Cell Homeostasis Is Controlled by IL-7 and IL-15 Together with Subset-Specific Factors

Baccalà

Witherden

Gonzalez-Quintial

et al. 2005

The Journal of Immunology

View full text Add to dashboard Cite

Among T cell subsets, γδ T cells uniquely display an Ag receptor-based tissue distribution, but what defines their preferential homing and homeostasis is unknown. To address this question, we studied the resources that control γδ T cell homeostasis in secondary lymphoid organs. We found that γδ and αβ T cells are controlled by partially overlapping resources, because acute homeostatic proliferation of γδ T cells was inhibited by an intact αβ T cell compartment, and both populations were dependent on IL-7 and IL-15. Significantly, to undergo acute homeostatic proliferation, γδ T cells also required their own depletion. Thus, γδ T cell homeostasis is maintained by trophic cytokines commonly used by other types of lymphoid cells, as well as by additional, as yet unidentified, γδ-specific factors.

show abstract

“…IL-7 was effective at supporting the survival of T cells in vitro, but was a very poor proliferative stimulus. It has been noted that IL-7 is unable to induce the proliferation of isolated T cells in vitro (51), possibly because a specific microenvironment is required for the appropriate display of IL-7 to responding cells (52). STAT5 phosphorylation, however, was induced strongly in these cells.…”

Section: Socs-1 Regulates ␥C-dependent Cytokine Signalingmentioning

confidence: 99%

Suppressor of Cytokine Signaling-1 Regulates Signaling in Response to Interleukin-2 and Other γc-dependent Cytokines in Peripheral T Cells

Cornish

Chong

Davey

et al. 2003

Journal of Biological Chemistry

115

View full text Add to dashboard Cite

Regulation of naïve and memory T-cell homeostasis

Cited by 69 publications

References 65 publications

T Cell Activation and Proliferation Characteristic for HIV-Nef Transgenic Mice Is Lymphopenia Induced

T Cell Activation and Proliferation Characteristic for HIV-Nef Transgenic Mice Is Lymphopenia Induced

γδ T Cell Homeostasis Is Controlled by IL-7 and IL-15 Together with Subset-Specific Factors

Suppressor of Cytokine Signaling-1 Regulates Signaling in Response to Interleukin-2 and Other γc-dependent Cytokines in Peripheral T Cells

Contact Info

Product

Resources

About