Regulation of Na+-coupled glucose carrier SGLT1 by human papillomavirus 18 E6 protein

Leiprecht, Natalie; Muñoz, Carlos; Alesutan, Ioana; Siraskar, Gulab; Sopjani, Mentor; Föller, Michael; Stubenrauch, Frank; Iftner, Thomas; Läng, Florian

doi:10.1016/j.bbrc.2010.12.044

Cited by 25 publications

(14 citation statements)

References 38 publications

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“…Several studies, indeed, correlate GLUT1 levels with aggressive tumor behavior as well as with the invasive and metastatic potential of transformed cells (Younes et al 1996b;Rudlowski et al 2003;Haber et al 1998). Moreover, the recent findings showing the additional expression of the sodium-dependent glucose cotransporter (SGLT1) in epithelial cancer cells (Mahraoui et al 1994;Leiprecht et al 2011), which is normally a requisite of intestinal and renal epithelial cells and endothelial cells at the blood-brain barrier, strengthens the pivotal role of the increased glucose transport capacity in carcinogenesis. Metabolic control analysis in hepatocarcinoma and cervical carcinoma cells provided evidence that the main control (71%) of glycolytic flux is exerted, besides GLUT1, by the enzyme hexokinase (HK) (Rodriguez-Enriquez et al 2009).…”

Section: Specific Glycolysis-related Enzymes Regulate Both the Warburmentioning

confidence: 92%

Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug

Cardaci

Desideri

Ciriolo

2012

J Bioenerg Biomembr

114

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The Warburg effect refers to the phenomenon whereby cancer cells avidly take up glucose and produce lactic acid under aerobic conditions. Although the molecular mechanisms underlying tumor reliance on glycolysis remains not completely clear, its inhibition opens feasible therapeutic windows for cancer treatment. Indeed, several small molecules have emerged by combinatorial studies exhibiting promising anticancer activity both in vitro and in vivo, as a single agent or in combination with other therapeutic modalities. Therefore, besides reviewing the alterations of glycolysis that occur with malignant transformation, this manuscript aims at recapitulating the most effective pharmacological therapeutics of its targeting. In particular, we describe the principal mechanisms of action and the main targets of 3-bromopyruvate, an alkylating agent with impressive antitumor effects in several models of animal tumors. Moreover, we discuss the chemo-potentiating strategies that would make unparalleled the putative therapeutic efficacy of its use in clinical settings.

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Section: Specific Glycolysis-related Enzymes Regulate Both the Warburmentioning

confidence: 92%

Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug

Cardaci

Desideri

Ciriolo

2012

J Bioenerg Biomembr

114

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“…SGLTs are capable to take up glucose into the tumor cell even against a high chemical gradient (Ganapathy et al, 2009). Several tumor entities such as colorectal, pancreatic, lung, head and neck, prostate, kidney, cervical, mammary, and bladder cancer as well as chondrosarcomas and leukemia have indeed been shown to up-regulate SGLTs (Nelson and Falk, 1993; Ishikawa et al, 2001; Helmke et al, 2004; Casneuf et al, 2008; Weihua et al, 2008; Yu et al, 2008; Leiprecht et al, 2011; Wright et al, 2011). The inwardly directed Na + gradient and the voltage across the plasma membrane drive the electrogenic SGLT-generated glucose transport into the cell.…”

Section: Ion Transports and Radioresistancementioning

confidence: 99%

Ionizing radiation, ion transports, and radioresistance of cancer cells

Huber¹,

Butz²,

Stegen³

et al. 2013

Front. Physiol.

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The standard treatment of many tumor entities comprises fractionated radiation therapy which applies ionizing radiation to the tumor-bearing target volume. Ionizing radiation causes double-strand breaks in the DNA backbone that result in cell death if the number of DNA double-strand breaks exceeds the DNA repair capacity of the tumor cell. Ionizing radiation reportedly does not only act on the DNA in the nucleus but also on the plasma membrane. In particular, ionizing radiation-induced modifications of ion channels and transporters have been reported. Importantly, these altered transports seem to contribute to the survival of the irradiated tumor cells. The present review article summarizes our current knowledge on the underlying mechanisms and introduces strategies to radiosensitize tumor cells by targeting plasma membrane ion transports.

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“…SGLTs allow efficient glucose uptake even from a glucose-depleted microenvironment which is typical for malperfused solid tumors [44]. It is therefore not surprising that several tumor entities such as colorectal, pancreatic, lung, head and neck, prostate, kidney, cervical, breast, bladder and prostate cancer as well as chondrosarcomas and leukemia upregulate SGLTs [45][46][47][48][49][50][51][52][53].…”

Section: Ion Channels Conferring Intrinsic Radioresistancementioning

confidence: 99%

Role of ion channels in ionizing radiation-induced cell death

Huber

Butz

Stegen

et al. 2015

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Neoadjuvant, adjuvant or definitive fractionated radiation therapy are implemented in first line anti-cancer treatment regimens of many tumor entities. Ionizing radiation kills the tumor cells mainly by causing double strand breaks of their DNA through formation of intermediate radicals. Survival of the tumor cells depends on both, their capacity of oxidative defense and their efficacy of DNA repair. By damaging the targeted cells, ionizing radiation triggers a plethora of stress responses. Among those is the modulation of ion channels such as Ca2+-activated K+ channels or Ca2+-permeable nonselective cation channels belonging to the super-family of transient receptor potential channels. Radiogenic activation of these channels may contribute to radiogenic cell death as well as to DNA repair, glucose fueling, radiogenic hypermigration or lowering of the oxidative stress burden. The present review article introduces these channels and summarizes our current knowledge on the mechanisms underlying radiogenic ion channel modulation. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers.

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Regulation of Na+-coupled glucose carrier SGLT1 by human papillomavirus 18 E6 protein

Cited by 25 publications

References 38 publications

Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug

Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug

Ionizing radiation, ion transports, and radioresistance of cancer cells

Role of ion channels in ionizing radiation-induced cell death

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