Regulation of muscle growth and regeneration by the immune system

Tidball, James G.

doi:10.1038/nri.2016.150

Cited by 546 publications

(832 citation statements)

References 129 publications

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“…Moreover, the number of differentiating satellite cells is decreased in aged mice, as shown by downregulation of differentiation markers such as desmin and myogenin (Charge, Brack, & Hughes, 2002; Collins, Zammit, Ruiz, Morgan, & Partridge, 2007). In addition to satellite cells, there is clear evidence supporting the essential role of immune cells both in the clearance of damaged tissue and enhancing tissue regeneration upon injury (Tidball, 2017). However, age‐related changes in the immune cell functions and its therapeutic potential remain elusive.…”

Section: Introduction Results Discussionmentioning

confidence: 99%

In vivo GDF3 administration abrogates aging related muscle regeneration delay following acute sterile injury

et al. 2018

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Tissue regeneration is a highly coordinated process with sequential events including immune cell infiltration, clearance of damaged tissues, and immune‐supported regrowth of the tissue. Aging has a well‐documented negative impact on this process globally; however, whether changes in immune cells per se are contributing to the decline in the body’s ability to regenerate tissues with aging is not clearly understood. Here, we set out to characterize the dynamics of macrophage infiltration and their functional contribution to muscle regeneration by comparing young and aged animals upon acute sterile injury. Injured muscle of old mice showed markedly elevated number of macrophages, with a predominance for Ly6Chigh pro‐inflammatory macrophages and a lower ratio of the Ly6Clow repair macrophages. Of interest, a recently identified repair macrophage‐derived cytokine, growth differentiation factor 3 (GDF3), was markedly downregulated in injured muscle of old relative to young mice. Supplementation of recombinant GDF3 in aged mice ameliorated the inefficient regenerative response. Together, these results uncover a deficiency in the quantity and quality of infiltrating macrophages during aging and suggest that in vivo administration of GDF3 could be an effective therapeutic approach.

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Section: Introduction Results Discussionmentioning

confidence: 99%

In vivo GDF3 administration abrogates aging related muscle regeneration delay following acute sterile injury

et al. 2018

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“…Acute muscle injuries provide a good model for the study of the modulating effect of immune cells on the tissue repair process 1. Immediately after an acute injury, muscle tissue undergoes the rapid invasion of inflammatory cells, mainly neutrophils and macrophages 1.…”

Section: Introductionmentioning

confidence: 99%

“…M2 macrophages produce anti‐inflammatory cytokines and growth factors as TGF‐ β and IL‐10 as well as enzymes that are important to angiogenesis, fibroblast proliferation and the differentiation of myogenic precursor cells 1, 4, 5. M2 macrophage surface marker CD206 is a mannose receptor that internalizes sugar moieties on molecules in inflamed tissue, such as myeloperoxidase 3.…”

Section: Introductionmentioning

confidence: 99%

“…CD163 is a specific receptor for hemoglobin and haptaglobin complexes 3. Specific binding to the both receptors triggers the expression of anti‐inflammatory cytokines, such as IL‐10 and TGF‐ β, leading to the deactivation of M1 macrophages1, 3, 4 and enabling the predominance of M2 macrophages at the injury site during the transition from the proliferative stage to the differentiation and growth stage of myogenesis 1, 3, 4…”

Section: Introductionmentioning

confidence: 99%

“…It is well accepted that although there are different degrees of differentiation between the populations of macrophages that inhabit the muscle tissue after an injury, the coordinated activation of proinflammatory or anti‐inflammatory macrophage predominance in each step of the muscle repair process is essential to the resolution of the inflammatory process and regeneration of the muscle tissue 1, 4, 5…”

Section: Introductionmentioning

confidence: 99%

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Photobiomodulation and different macrophages phenotypes during muscle tissue repair

Souza

Mesquita‐Ferrari

Rodrigues

et al. 2018

J Cellular Molecular Medi

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Macrophages play a very important role in the conduction of several regenerative processes mainly due to their plasticity and multiple functions. In the muscle repair process, while M1 macrophages regulate the inflammatory and proliferative phases, M2 (anti‐inflammatory) macrophages direct the differentiation and remodelling phases, leading to tissue regeneration. The aim of this study was to evaluate the effect of red and near infrared (NIR) photobiomodulation (PBM) on macrophage phenotypes and correlate these findings with the repair process following acute muscle injury. Wistar rats were divided into 4 groups: control; muscle injury; muscle injury + red PBM; and muscle injury + NIR PBM. After 2, 4 and 7 days, the tibialis anterior muscle was processed for analysis. Macrophages phenotypic profile was evaluated by immunohistochemistry and correlated with the different stages of the skeletal muscle repair by the qualitative and quantitative morphological analysis as well as by the evaluation of IL‐6,TNF‐α and TGF‐β mRNA expression. Photobiomodulation at both wavelengths was able to decrease the number of CD68+ (M1) macrophages 2 days after muscle injury and increase the number of CD163+ (M2) macrophages 7 days after injury. However, only NIR treatment was able to increase the number of CD206+ M2 macrophages (Day 2) and TGF ‐β mRNA expression (Day 2, 4 and 7), favouring the repair process more expressivelly. Treatment with PBM was able to modulate the inflammation phase, optimize the transition from the inflammatory to the regeneration phase (mainly with NIR light) and improve the final step of regeneration, enhancing tissue repair.

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A Flexible Aptameric Graphene Field‐Effect Nanosensor Capable of Automatic Liquid Collection/Filtering for Cytokine Storm Biomarker Monitoring in Undiluted Sweat

Huang,

Li,

Liu

et al. 2023

Adv Funct Materials

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A wearable sensor capable of directly detecting cytokines in external secretions external to the human body is pivotal for gauging the intensity of the immune response and circumventing inflammatory storms, a significant clinical concern. The detection of low‐concentration cytokines is often hampered due to interference from impurities in secretions. Addressing this challenge, a wearable detection system is developed by integrating a Janus membrane with water auto‐collection/filtering capabilities, and aptamer‐modified graphene field‐effect transistor sensors, enabling the detection of low‐concentration cytokines in undiluted sweat samples. The Janus membrane can automatically filter external secretions and transport them to the sensor surface, effectively eliminating impurity interference and enhancing the sensor's detection capabilities. The device can sensitively detect cytokines (such as TNF‐α, a marker for inflammation and cancer) in undiluted sweat, with a detection range spanning 0.5 to 500 pM, and a detection limit reaching 0.31 pM. The ultra‐flexibility of the sensor is also verified, maintaining stable electrical properties even after enduring up to 50 extreme deformations. These findings indicate that the wearable detection system has the potential to realize low‐concentration cytokines monitoring in the sweat of inflammatory patients, to assist the healthcare system in controlling the body's immune status.

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Regulation of muscle growth and regeneration by the immune system

Cited by 546 publications

References 129 publications

In vivo GDF3 administration abrogates aging related muscle regeneration delay following acute sterile injury

In vivo GDF3 administration abrogates aging related muscle regeneration delay following acute sterile injury

Photobiomodulation and different macrophages phenotypes during muscle tissue repair

A Flexible Aptameric Graphene Field‐Effect Nanosensor Capable of Automatic Liquid Collection/Filtering for Cytokine Storm Biomarker Monitoring in Undiluted Sweat

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