Abstract:Voltage-dependent L-type Ca 2+ channel (VDCC L ) and T-type Ca 2+ channel (VDCC T ) in murine myometrium was identified in murine myometrium. Its regulatory functions were characterized by using extracts of ginger. Methanol extract of ginger was used to obtain dichloromethane fraction (Gin C). Spontaneous uterine contractions were enhanced by BayK 8644, a VDCC L activator. However, such effects were inhibited by nifedipine (a VDCC L blocker) and mibefradil (a VDCC T blocker). Mibefradil also inhibited oxytocin… Show more
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