Regulation of middle cerebral artery blood velocity during recovery from dynamic exercise in humans

Ogoh, Shigehiko; Fisher, James; Purkayastha, Sushmita; Dawson, Ellen A.; Fadel, Paul J.; White, Michael; Zhang, Rong; Secher, Niels H.; Raven, Peter B.

doi:10.1152/japplphysiol.00801.2006

Cited by 39 publications

(34 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MBV and VCI in the MCA did not differ between pre-treatment and the pre-task baseline in both trials, suggesting that neither vasoconstriction nor vasodilation occurred in the cerebral region after the end of exercise, partly consistent with the previous study which reported no significant change in MCA during 1 to 8 min after the exercise at HR of 90, 120, and 150 bpm [21]. …”

Section: Discussionsupporting

confidence: 89%

Effect of preceding exercise on cerebral and splanchnic vascular responses to mental task

Someya

Ikemura

Hayashi

2012

J Physiol Anthropol

View full text Add to dashboard Cite

BackgroundTo investigate the effect of preceding acute exercise on the peripheral vascular response to a mental task, we measured splanchnic and cerebral blood flow responses to performing a mental task after exercise and resting.MethodsIn the exercise trial, 11 males exercised for 30 min on a cycle ergometer with a workload set at 70% of the age-predicted maximal heart rate for each individual. After a 15-min recovery period, the subjects rested for 5 min for pre-task baseline measurement and then performed mental arithmetic for 5 min followed by 5 min of post-task measurement. In the resting trial, they rested for 45 min and pre-task baseline data was obtained for 5 min. Then mental arithmetic was performed for 5 min followed by post-task measurement. We measured the mean blood velocity in the middle cerebral artery and superior mesenteric artery and the mean arterial pressure.ResultsMean arterial pressure and mean blood velocity in the middle cerebral artery were significantly higher than the baseline during mental arithmetic in both exercise and resting trials. Mean blood velocity in the middle cerebral artery during mental arithmetic was greater in the control trial than the exercise trial. Mean blood velocity in the superior mesenteric artery showed no significant change during mental arithmetic from baseline in both trials.ConclusionThese results suggest that acute exercise can moderate the increase in cerebral blood flow induced by a mental task.

show abstract

Section: Discussionsupporting

confidence: 89%

Effect of preceding exercise on cerebral and splanchnic vascular responses to mental task

Someya

Ikemura

Hayashi

2012

J Physiol Anthropol

View full text Add to dashboard Cite

show abstract

“…In both supine and upright positions, 5 min steady‐state baseline ABP and MCA V beat‐to‐beat signals were re‐sampled at 2 Hz for spectral analysis (Ogoh et al., 2005a, b, ). Dynamic CA was calculated as the transfer function gain and phase shift between fluctuations in ABP and MCA V (Ogoh et al., 2005a, b, ). The transfer gain and phase shift reflect the relative amplitude and time relationship between the changes in ABP and MCA V over a specified frequency range.…”

Section: Methodsmentioning

confidence: 99%

Relationship between aerobic endurance training and dynamic cerebral blood flow regulation in humans

Ichikawa

Miyazawa

Horiuchi

et al. 2013

Scandinavian Med Sci Sports

View full text Add to dashboard Cite

The incidence of orthostatic intolerance is elevated in endurance-trained individuals. We sought to test the hypothesis that aerobic endurance training is associated with an attenuated control of the cerebral vasculature. Endurance trained (ET, n = 13) and age-matched untrained (UT, n = 11) individuals (peak O2 consumption, mean ± SEM; 63 ± 1 vs 42 ± 1 mL/min/kg, P < 0.05) were examined while supine and seated upright. Dynamic cerebral autoregulation (CA) was assessed by calculation of the rate of regulation (RoR) from the arterial blood pressure (ABP) and middle cerebral artery (MCA) mean blood velocity (V mean ) responses to a bilateral thigh cuff release, which evoked a transient hypotension. Cerebral oxygenation (oxyhemoglobin; HbO2 ) was determined with near-infrared spectroscopy. When seated upright, cuff release evoked a greater decrease in ABP (P < 0.001), MCA V mean (P = 0.096) and HbO2 (P < 0.001) in ET compared with UT. However, RoR was similar in ET and UT individuals while seated upright (to 0.193 ± 0.039 vs 0.129 ± 0.029/s, P > 0.05), and there was no significant difference in the relative change in RoR from the supine to upright positions (ΔRoR: -65 ± 7 and -69 ± 7%, for ET and UT, respectively). These findings suggest that aerobic endurance training is not associated with an attenuation in dynamic CA.

show abstract

“…While cerebral autoregulation is well-maintained following moderate intensity exercise (Ogoh et al , 2007; Murrell et al , 2007; Willie et al , 2013), two studies suggest that more intense exercise may produce a lasting cerebral autoregulatory deficit. Specifically, Ogoh et al (2005) found reduced dynamic cerebral autoregulation (as assessed by transfer function) during heavy cycle exercise and Bailey et al (2011) found reduced dynamic cerebral autoregulation (as assessed by thigh-cuff release) during recovery from a recumbent cycle peak test.…”

Section: Part 2: Exploration Of Different Exercise Models That Generamentioning

confidence: 99%

Blood pressure regulation X: what happens when the muscle pump is lost? Post-exercise hypotension and syncope

et al. 2013

View full text Add to dashboard Cite

Syncope which occurs suddenly in the setting of recovery from exercise, known as post-exercise syncope, represents a failure of integrative physiology during recovery from exercise. We estimate that between 50 and 80% of healthy individuals will develop pre-syncopal signs and symptoms if subjected to a 15-min head-up tilt following exercise. Post-exercise syncope is most often neurally mediated syncope during recovery from exercise, with a combination of factors associated with post-exercise hypotension and loss of the muscle pump contributing to the onset of the event. One can consider the initiating reduction in blood pressure as the tip of the proverbial iceberg. What is needed is a clear model of what lies under the surface; a model that puts the observational variations in context and provides a rational framework for developing strategic physical or pharmacological countermeasures to ultimately protect cerebral perfusion and avert loss of consciousness. This review summarizes the current mechanistic understanding of post-exercise syncope and attempts to categorize the variation of the physiological processes that arise in multiple exercise settings. Newer investigations into the basic integrative physiology of recovery from exercise provide insight into the mechanisms and potential interventions that could be developed as countermeasures against post-exercise syncope. While physical counter maneuvers designed to engage the muscle pump and augment venous return are often found to be beneficial in preventing a significant drop in blood pressure after exercise, countermeasures that target the respiratory pump and pharmacological countermeasures based on the involvement of histamine receptors show promise.

show abstract

Regulation of middle cerebral artery blood velocity during recovery from dynamic exercise in humans

Cited by 39 publications

References 29 publications

Effect of preceding exercise on cerebral and splanchnic vascular responses to mental task

Effect of preceding exercise on cerebral and splanchnic vascular responses to mental task

Relationship between aerobic endurance training and dynamic cerebral blood flow regulation in humans

Blood pressure regulation X: what happens when the muscle pump is lost? Post-exercise hypotension and syncope

Contact Info

Product

Resources

About