Regulation of microglia phagocytosis and potential involvement of exercise

Li, Congqin; Wang, Yong; Xing, Ying; Han, Jianda; Zhang, Yuqian; Zhang, Anjing; Hu, Jian; Hua, Yan; Yang, Bai

doi:10.3389/fncel.2022.953534

Cited by 13 publications

(7 citation statements)

References 123 publications

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“…However, the effective of IFN-β is dose dependent. Excessive IFN-β responses have harmful effects and facilitate the development of autoimmune diseases ( 112 ). Therefore, proper regulation of the expression and activation of type I IFNs is essential for tissue homeostasis ( 2 ).…”

Section: Commensal Bacteria and Trophoblasts Interactionsmentioning

confidence: 99%

Fetal-maternal interactions during pregnancy: a ‘three-in-one’ perspective

2023

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A successful human pregnancy requires the maternal immune system to recognize and tolerate the semi-allogeneic fetus, allowing for appropriate trophoblasts invasion and protecting the fetus from invading pathogens. Therefore, maternal immunity is critical for the establishment and maintenance of pregnancy, especially at the maternal-fetal interface. Anatomically, the maternal-fetal interface has both maternally- and fetally- derived cells, including fetal originated trophoblasts and maternal derived immune cells and stromal cells. Besides, a commensal microbiota in the uterus was supposed to aid the unique immunity in pregnancy. The appropriate crosstalk between fetal derived and maternal originated cells and uterine microbiota are critical for normal pregnancy. Dysfunctional maternal-fetal interactions might be associated with the development of pregnancy complications. This review elaborates the latest knowledge on the interactions between trophoblasts and decidual immune cells, highlighting their critical roles in maternal-fetal tolerance and pregnancy development. We also characterize the role of commensal bacteria in promoting pregnancy progression. Furthermore, this review may provide new thought on future basic research and the development of clinical applications for pregnancy complications.

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Section: Commensal Bacteria and Trophoblasts Interactionsmentioning

confidence: 99%

Fetal-maternal interactions during pregnancy: a ‘three-in-one’ perspective

2023

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“…We demonstrate here that there is a window during early postnatal life where experience can induce a highly localized increase in the reactivity of microglia to selectively engulf miswired neural projections to drive normative changes. Previous studies have demonstrated that altered experience, including EE, can influence microglial‐engulfment (Augusto‐Oliveira & Verkhratsky, 2021; Li et al, 2022). Much of this work, however, has focused on how experience modulates microglial reactivity as part of the inflammatory response to pathological insult.…”

Section: Discussionmentioning

confidence: 99%

An early enriched experience drives targeted microglial engulfment of miswired neural circuitry during a restricted postnatal period

Rogerson‐Wood,

Goldsbury,

Sawatari

et al. 2024

Glia

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Brain function is critically dependent on correct circuit assembly. Microglia are well‐known for their important roles in immunological defense and neural plasticity, but whether they can also mediate experience‐induced correction of miswired circuitry is unclear. Ten‐m3 knockout (KO) mice display a pronounced and stereotyped visuotopic mismapping of ipsilateral retinal inputs in their visual thalamus, providing a useful model to probe circuit correction mechanisms. Environmental enrichment (EE) commenced around birth, but not later in life, can drive a partial correction of the most mismapped retinal inputs in Ten‐m3 KO mice. Here, we assess whether enrichment unlocks the capacity for microglia to selectively engulf and remove miswired circuitry, and the timing of this effect. Expression of the microglial‐associated lysosomal protein CD68 showed a clear enrichment‐driven, spatially restricted change which had not commenced at postnatal day (P)18, was evident at P21, more robust at P25, and had ceased by P30. This was observed specifically at the corrective pruning site and was absent at a control site. An engulfment assay at the corrective pruning site in P25 mice showed EE‐driven microglial‐uptake of the mismapped axon terminals. This was temporally and spatially specific, as no enrichment‐driven microglial engulfment was seen in P18 KO mice, nor the control locus. The timecourse of the EE‐driven corrective pruning as determined anatomically, aligned with this pattern of microglia reactivity and engulfment. Collectively, these findings show experience can drive targeted microglial engulfment of miswired neural circuitry during a restricted postnatal window. This may have important therapeutic implications for neurodevelopmental conditions involving aberrant neural connectivity.

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“…The putamen is a common site for synaptic pruning, and depression was reported to disrupt such a process [ 80 , 81 ]. We speculate that the reduced putamen volume found in the Tai Chi training group could have been due to the post-intervention effect on restoring the pruning process [ 82 ]. Future study is to gather additional evidence to support our speculation.…”

Section: Discussionmentioning

confidence: 99%

Effect of Tai Chi on Young Adults with Subthreshold Depression via a Stress–Reward Complex: A Randomized Controlled Trial

Wu,

Song,

et al. 2023

Sports Med - Open

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Background Subthreshold depression is a highly prevalent mood disorder in young adults. Mind–body exercises, such as Tai Chi, have been adopted as interventions for clinical depressive symptoms. However, the possible effect and underlying mechanism of Tai Chi on subthreshold depression of young individuals remain unclear. This randomized controlled study aimed to evaluate the effects of Tai Chi training and tested the combined stress and reward circuitry model for subthreshold depression. Results A total of 103 participants completed this trial, with 49 in the 12-week 24-style Tai Chi group and 54 participants in control group. Our results showed significantly lower scores on depressive symptoms (P = 0.002) and anxiety symptoms (P = 0.009) and higher scores on quality of life (P = 0.002) after Tai Chi training. There were significant reductions in salivary cortisol levels (P = 0.007) and putamen gray matter volume (P < 0.001) in the Tai Chi group. The changes in cortisol levels and putamen gray matter volume had direct (bootstrapping confidence interval [− 0.91, − 0.11]) and indirect effects (bootstrapping confidence interval [− 0.65, − 0.19]) on the changes induced by Tai Chi training on depressive symptoms, respectively. Conclusion The stress–reward complex results indicated an interaction between lowering stress levels and increasing reward circuitry activity associated with the alleviation of depressive symptoms among participants. The 12-week Tai Chi training was effective in improving the symptoms and quality of life of young adults with subthreshold depression. Trial Registration Chinese Registry of Clinical Trials (Registration Number: ChiCTR1900028289, Registered December 12, 2019).

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Regulation of microglia phagocytosis and potential involvement of exercise

Cited by 13 publications

References 123 publications

Fetal-maternal interactions during pregnancy: a ‘three-in-one’ perspective

Fetal-maternal interactions during pregnancy: a ‘three-in-one’ perspective

An early enriched experience drives targeted microglial engulfment of miswired neural circuitry during a restricted postnatal period

Effect of Tai Chi on Young Adults with Subthreshold Depression via a Stress–Reward Complex: A Randomized Controlled Trial

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