Regulation of metastatic potential by drug repurposing and mitochondrial targeting in colorectal cancer cells
Shashank Mathur,
Pransu Srivastava,
Anubhav Srivastava
et al.
Abstract:Background
Increased mitochondrial activities contributing to cancer cell proliferation, invasion, and metastasis have been reported in different cancers; however, studies on the therapeutic targeting of mitochondria in regulating cell proliferation and invasiveness are limited. Because mitochondria are believed to have evolved through bacterial invasion in mammalian cells, antibiotics could provide an alternative approach to target mitochondria, especially in cancers with increased mitochondri… Show more
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