Regulation of main ncRNAs by polyphenols: A novel anticancer therapeutic approach

Zhang, Liang; Kang, Qingzheng; Kang, Mengxiao; Jiang, Suwei; Yang, Feng; Gong, Jun; Ou, Gaozhi; Wang, Song

doi:10.1016/j.phymed.2023.155072

Cited by 4 publications

(2 citation statements)

References 163 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, this intervention yielded reduced overall DNA methylation levels, while tested tumor suppressor genes exhibited a significant dose-dependent reduction in promoter methylation, leading to the reinstatement of their expression [ 308 ]. The influence of propolis and its bioactive components, with a particular emphasis on quercetin, in shaping microRNA expression presents an engaging avenue for regulating inflammation, differentiation, proliferation, apoptosis, and immune responses [ 197 , 309 , 310 , 311 , 312 , 313 ].…”

Section: Epigeneticsmentioning

confidence: 99%

Exploring the Prospective Role of Propolis in Modifying Aging Hallmarks

Scorza,

Goncalves,

Finsterer

et al. 2024

Cells

View full text Add to dashboard Cite

Aging populations worldwide are placing age-related diseases at the forefront of the research agenda. The therapeutic potential of natural substances, especially propolis and its components, has led to these products being promising agents for alleviating several cellular and molecular-level changes associated with age-related diseases. With this in mind, scientists have introduced a contextual framework to guide future aging research, called the hallmarks of aging. This framework encompasses various mechanisms including genomic instability, epigenetic changes, mitochondrial dysfunction, inflammation, impaired nutrient sensing, and altered intercellular communication. Propolis, with its rich array of bioactive compounds, functions as a potent functional food, modulating metabolism, gut microbiota, inflammation, and immune response, offering significant health benefits. Studies emphasize propolis’ properties, such as antitumor, cardioprotective, and neuroprotective effects, as well as its ability to mitigate inflammation, oxidative stress, DNA damage, and pathogenic gut bacteria growth. This article underscores current scientific evidence supporting propolis’ role in controlling molecular and cellular characteristics linked to aging and its hallmarks, hypothesizing its potential in geroscience research. The aim is to discover novel therapeutic strategies to improve health and quality of life in older individuals, addressing existing deficits and perspectives in this research area.

show abstract

Section: Epigeneticsmentioning

confidence: 99%

Exploring the Prospective Role of Propolis in Modifying Aging Hallmarks

Scorza,

Goncalves,

Finsterer

et al. 2024

Cells

View full text Add to dashboard Cite

show abstract

“…Recent studies have highlighted the potential of plant polyphenols in oncotherapy, demonstrating their capacity to modulate ncRNAs, including miRNAs and lncRNAs (Ruiz-Manriquez et al, 2022;Zhang et al, 2023). Recent investigations have revealed the involvement of lncRNAs in the context of polyphenol-induced suppression of carcinogenesis (Veeraraghavan et al, 2022).…”

mentioning

confidence: 99%

Modulation of long noncoding RNAs by polyphenols as a novel potential therapeutic approach in lung cancer: A comprehensive review

Lv,

Qian,

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

Lung cancer stands as a formidable global health challenge, necessitating innovative therapeutic strategies. Polyphenols, bioactive compounds synthesized by plants, have garnered attention for their diverse health benefits, particularly in combating various cancers, including lung cancer. The advent of whole‐genome and transcriptome sequencing technologies has illuminated the pivotal roles of long noncoding RNAs (lncRNAs), operating at epigenetic, transcriptional, and posttranscriptional levels, in cancer progression. This review comprehensively explores the impact of polyphenols on both oncogenic and tumor‐suppressive lncRNAs in lung cancer, elucidating on their intricate regulatory mechanisms. The comprehensive examination extends to the potential synergies when combining polyphenols with conventional treatments like chemotherapy, radiation, and immunotherapy. Recognizing the heterogeneity of lung cancer subtypes, the review emphasizes the need for the integration of nanotechnology for optimized polyphenol delivery and personalized therapeutic approaches. In conclusion, we collect the latest research, offering a holistic overview of the evolving landscape of polyphenol‐mediated modulation of lncRNAs in lung cancer therapy. The integration of polyphenols and lncRNAs into multidimensional treatment strategies holds promise for enhancing therapeutic efficacy and navigating the challenges associated with lung cancer treatment.

show abstract

Hepatic miR-363 promotes nonalcoholic fatty liver disease by suppressing INSIG1

Wang,

Jia,

et al. 2024

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

Regulation of main ncRNAs by polyphenols: A novel anticancer therapeutic approach

Cited by 4 publications

References 163 publications

Exploring the Prospective Role of Propolis in Modifying Aging Hallmarks

Exploring the Prospective Role of Propolis in Modifying Aging Hallmarks

Modulation of long noncoding RNAs by polyphenols as a novel potential therapeutic approach in lung cancer: A comprehensive review

Hepatic miR-363 promotes nonalcoholic fatty liver disease by suppressing INSIG1

Contact Info

Product

Resources

About