2008
DOI: 10.5483/bmbrep.2008.41.4.316
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Regulation of macrophage inflammatory protein-2 gene expression in response to 2,4-dinitrofluorobenzene in RAW 264.7 cells

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Cited by 11 publications
(15 citation statements)
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“…In addition, the exposure of skin-derived dendritic cells to DNFB induces activation of the p38 MAP kinase and ERK1/2 in the regulation of CD40 expression (5). In a previous study, we found that the production of ROS was associated with activation of the MIP-2 gene promoter by DNFB, and that this occurred via activation of the p38 MAP kinase and ERK1/2 pathways (16,17).…”
Section: Introductionmentioning
confidence: 99%
“…In addition, the exposure of skin-derived dendritic cells to DNFB induces activation of the p38 MAP kinase and ERK1/2 in the regulation of CD40 expression (5). In a previous study, we found that the production of ROS was associated with activation of the MIP-2 gene promoter by DNFB, and that this occurred via activation of the p38 MAP kinase and ERK1/2 pathways (16,17).…”
Section: Introductionmentioning
confidence: 99%
“…However, considering the variation observed during experiments in the THP-1 human monocytic leukemia cell line as a model system, the effect of skin sensitizers on CD83 expression appears to be unstable (25). We reported previously that DNFB is involved in activating mouse macrophages in the dermis of NC/Nga mice (19). The results showed that DNFB upregulates MIP-2 expression in the dermis and the RAW264.7 macrophage cell line based on the MAPK signaling pathway.…”
Section: Expression Of Mhc Class II and Costimulatory Molecules In Dnmentioning
confidence: 88%
“…To analyze CD83 expression, total RNAs were extracted with an RNeasy Mini Kit (Qiagen, Valencia, CA, USA) from RAW 264.7 cells or skin tissues, and cDNA was generated as described previously (19). One microliter of the cDNA mixture was subjected to the standard PCR reaction for 25 cycles of denaturation for 30 sec at 95ºC, annealing for 60 sec at 58ºC , and elongation for 60 sec at 72 o C. The primer sequences used are as followings.…”
Section: Reverse Transcription-polymerase Chain Reaction (Rt-pcr) Anamentioning
confidence: 99%
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