Regulation of Long Non-Coding RNAs by Plant Secondary Metabolites: A Novel Anticancer Therapeutic Approach

Kalhori, Mohammad Reza; Khodayari, Hamid; Khodayari, Saeed; Vesovic, Miko; Jackson, Gloria; Farzaei, Mohammad Hosein; Bishayee, Anupam

doi:10.3390/cancers13061274

Cited by 27 publications

(35 citation statements)

References 226 publications

(144 reference statements)

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“…A number of the target genes are important in regulation of the cell cycle and apoptosis. LncRNAs regulated by DIM include PCGEM1, HOTAIR and CCAT-L (65)(66)(67). This induction/repression of miRNAs and LncRNAs may be due, in part, to DIM-dependent binding to transcription factors such as AHR or AR.…”

Section: In Vitro Studiesmentioning

confidence: 99%

Indoles Derived From Glucobrassicin: Cancer Chemoprevention by Indole-3-Carbinol and 3,3'-Diindolylmethane

Williams

2021

Front. Nutr.

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Hydrolysis of glucobrassicin by plant or bacterial myrosinase produces multiple indoles predominantly indole-3-carbinol (I3C). I3C and its major in vivo product, 3,3'-diindolylmethane (DIM), are effective cancer chemopreventive agents in pre-clinical models and show promise in clinical trials. The pharmacokinetics/pharmacodynamics of DIM have been studied in both rodents and humans and urinary DIM is a proposed biomarker of dietary intake of cruciferous vegetables. Recent clinical studies at Oregon State University show surprisingly robust metabolism of DIM in vivo with mono- and di-hydroxylation followed by conjugation with sulfate or glucuronic acid. DIM has multiple mechanisms of action, the most well-characterized is modulation of aryl hydrocarbon receptor (AHR) signaling. In rainbow trout dose-dependent cancer chemoprevention by dietary I3C is achieved when given prior to or concurrent with aflatoxin B1, polycyclic aromatic hydrocarbons, nitrosamines or direct acting carcinogens such as N-methyl-N'-nitro-nitrosoguanidine. Feeding pregnant mice I3C inhibits transplacental carcinogenesis. In humans much of the focus has been on chemoprevention of breast and prostate cancer. Alteration of cytochrome P450-dependent estrogen metabolism is hypothesized to be an important driver of DIM-dependent breast cancer prevention. The few studies done to date comparing glucobrassicin-rich crucifers such as Brussels sprouts with I3C/DIM supplements have shown the greater impact of the latter is due to dose. Daily ingestion of kg quantities of Brussels sprouts is required to produce in vivo levels of DIM achievable by supplementation. In clinical trials these supplement doses have elicited few if any adverse effects. Sulforaphane from glucoraphanin can act synergistically with glucobrassicin-derived DIM and this may lead to opportunities for combinatorial approaches (supplement and food-based) in the clinic.

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Section: In Vitro Studiesmentioning

confidence: 99%

Indoles Derived From Glucobrassicin: Cancer Chemoprevention by Indole-3-Carbinol and 3,3'-Diindolylmethane

Williams

2021

Front. Nutr.

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“…Another treatment approach involving lncRNAs comprises the use of natural plant secondary metabolites (phytochemicals) with proven anti-tumor activity, such as curcumin, genistein, quercetin or resveratrol. These and other compounds have been found to affect the expression of cancer-related lncRNAs and might be regarded as promising anti-cancer drugs [ 225 ].…”

Section: Lncrnas Involved In Melanoma Drug Resistance and Treatment Responsementioning

confidence: 99%

The Functional Role of Long Non-Coding RNAs in Melanoma

Wozniak

Czyż

2021

Cancers

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Melanoma is the most lethal skin cancer, with increasing incidence worldwide. The molecular events that drive melanoma development and progression have been extensively studied, resulting in significant improvements in diagnostics and therapeutic approaches. However, a high drug resistance to targeted therapies and adverse effects of immunotherapies are still a major challenge in melanoma treatment. Therefore, the elucidation of molecular mechanisms of melanomagenesis and cancer response to treatment is of great importance. Recently, many studies have revealed the close association of long noncoding RNAs (lncRNAs) with the development of many cancers, including melanoma. These RNA molecules are able to regulate a plethora of crucial cellular processes including proliferation, differentiation, migration, invasion and apoptosis through diverse mechanisms, and even slight dysregulation of their expression may lead to tumorigenesis. lncRNAs are able to bind to protein complexes, DNA and RNAs, affecting their stability, activity, and localization. They can also regulate gene expression in the nucleus. Several functions of lncRNAs are context-dependent. This review summarizes current knowledge regarding the involvement of lncRNAs in melanoma. Their possible role as prognostic markers of melanoma response to treatment and in resistance to therapy is also discussed

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“…Due to their minor side effects, natural products have been used as chemotherapeutic agents against various cancers. These natural products modulate deregulated signaling pathways by downregulating oncogenic miRNAs and lncRNAs that play a crucial role in the development of tumorigenesis and maintain a delicate balance of tumor suppressor miRNAs and lncRNAs 150,151 . Plant lectins are a widespread group of lectin carbohydrate‐binding proteins with an affinity for binding to glycans of glycoproteins 152 .…”

Section: Cancer Treatmentmentioning

confidence: 99%

“…These natural products modulate deregulated signaling pathways by downregulating oncogenic miR-NAs and lncRNAs that play a crucial role in the development of tumorigenesis and maintain a delicate balance of tumor suppressor miRNAs and lncRNAs. 150,151 Plant lectins are a widespread group of lectin carbohydratebinding proteins with an affinity for binding to glycans of glycoproteins. 152 Previous studies have shown that many plant lectins have anticancer properties and induce autophagy or apoptosis through modulating various signaling pathways such as the Bcl-2 family, ATG families, caspase family, PI3K/Akt, and Ras-Raf in the cancer cells.…”

Section: Natural Productsmentioning

confidence: 99%

The potential role of miR‐1290 in cancer progression, diagnosis, prognosis, and treatment: An oncomiR or onco‐suppressor microRNA?

Kalhori

Soleimani

Arefian

et al. 2021

J of Cellular Biochemistry

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Cancer is one of the leading causes of death in humans because of the lack of early diagnosis, distant metastases, and the resistance to adjuvant therapies, including chemotherapy and radiotherapy. In addition to playing an essential role in tumor progression and development, microRNAs (miRNAs) can be used as a robust biomarker in the early detection of cancer. MiR‐1290 was discovered for the first time in human embryonic stem cells, and under typical physiological situations, plays an essential role in neuronal differentiation and neural stem cell proliferation. Its coding sequence is located at the 1p36.13 regions in the first intron of the aldehyde dehydrogenase 4 gene member A1. miR‐1290 is out of control in many cancers such as breast cancer, colorectal cancer, esophageal squamous cell carcinoma, gastric cancer, lung cancer, pancreatic cancer, and plays a vital role in their development. Therefore, it is suggested that miR‐1290 can be considered as a potential diagnostic and therapeutic target in many cancers. In addition to the importance of miR‐1290 in the noninvasive diagnosis of various cancers, this systematic review study discussed the role of miR‐1290 in altering the expression of different genes involved in cancer development and chemo‐radiation resistance. Moreover, it considered the regulatory effect of natural products on miR‐1290 expression and the interaction of lncRNAs by miR‐1290.

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Regulation of Long Non-Coding RNAs by Plant Secondary Metabolites: A Novel Anticancer Therapeutic Approach

Cited by 27 publications

References 226 publications

Indoles Derived From Glucobrassicin: Cancer Chemoprevention by Indole-3-Carbinol and 3,3'-Diindolylmethane

Indoles Derived From Glucobrassicin: Cancer Chemoprevention by Indole-3-Carbinol and 3,3'-Diindolylmethane

The Functional Role of Long Non-Coding RNAs in Melanoma

The potential role of miR‐1290 in cancer progression, diagnosis, prognosis, and treatment: An oncomiR or onco‐suppressor microRNA?

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