Regulation of Local Ambient GABA Levels via Transporter-Mediated GABA Import and Export for Subliminal Learning

Hoshino, Osamu

doi:10.1162/neco_a_00733

Cited by 5 publications

(1 citation statement)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(1)]. For model parameters and their values, see Table 1 and our previous studies (Hoshino 2008a(Hoshino , 2009(Hoshino , 2010(Hoshino , 2011b(Hoshino , 2012(Hoshino , 2013(Hoshino , 2015.…”

Section: Appendix 2: Receptor Dynamicsmentioning

confidence: 99%

GABA diffusion across neuronal columns for efficient sensory tuning

2015

Self Cite

View full text Add to dashboard Cite

Synaptic (phasic) lateral inhibition between neuronal columns mediated by GABAergic interneurons is, in general, essential for primary sensory cortices to respond selectively to elemental features. We propose here a neural network model with a nonsynaptic (tonic) lateral inhibitory mechanism. While firing, intrasynaptic GABA molecules spill over into extracellular space and accumulate in neuronal columns. Through accumulation in and diffusion across these columns, a level of ambient (extracellular) GABA changes in a neuronal activity-dependent manner. Ambient GABA molecules act on extrasynaptic receptors and provide neurons with tonic inhibitory currents. We examined whether and how the diffusion of GABA molecules across neuronal columns affects tuning performance of the network to a feature stimulus: selective responsiveness. The GABA diffusion led to reducing ambient GABA in the stimulus-relevant column while augmenting ambient GABA in stimulus-irrelevant columns, thereby improving the tuning performance. The GABA diffusion was effective especially when provided with a broader sensory input. Interestingly, this diffusion-based, nonsynaptic (tonic) lateral inhibitory scheme worked well together with the conventional, synaptic (phasic) lateral inhibitory scheme, enhancing the sensory tuning. We suggest that the nonsynaptic lateral inhibition, mediated through GABA diffusion across neuronal columns, may be beneficial for the cortex to tune to sensory features.

show abstract

Section: Appendix 2: Receptor Dynamicsmentioning

confidence: 99%

GABA diffusion across neuronal columns for efficient sensory tuning

2015

Self Cite

View full text Add to dashboard Cite

show abstract

Improvement of Sensory Information Processing by Balancing Tonic and Phasic Subthreshold Neuronal Excitation

Ishiyama

Matsui

Tsuboi

et al. 2016

2016 Joint 8th International Conference on Soft Computing and Intelligent Systems (SCIS) and 17th International Symposium on Ad

View full text Add to dashboard Cite

Reduction of Trial-to-Trial Perceptual Variability by Intracortical Tonic Inhibition

2016

View full text Add to dashboard Cite

Variability is a prominent characteristic of cognitive brain function. For instance, different trials of presentation of the same stimulus yield higher variability in its perception: subjects sometimes fail in perceiving the same stimulus. Perceptual variability could be attributable to ongoing-spontaneous fluctuation in neuronal activity prior to sensory stimulation. Simulating a cortical neural network model, we investigated the underlying neuronal mechanism of perceptual variability in relation to variability in ongoing-spontaneous neuronal activity. In the network model, populations of principal cells (cell assemblies) encode information about sensory features. Each cell assembly is sensitive to one particular feature stimulus. Transporters on GABAergic interneurons regulate ambient GABA concentration in a neuronal activity-dependent manner. Ambient GABA molecules activate extrasynaptic GABAa receptors on principal cells and interneurons, and provide them with tonic inhibitory currents. We controlled the variability of ongoing-spontaneous neuronal activity by manipulating the basal level of ambient GABA and assessed the perceptual performance of the network: detection of a feature stimulus. In an erroneous response, stimulus-irrelevant but not stimulus-relevant principal cells were activated, generating trains of action potentials. Perceptual variability, reflected in error rate in detecting the same stimulus that was presented repeatedly to the network, was increased as the variability in ongoing-spontaneous membrane potential among cell assemblies increased. Frequent, transient membrane depolarization below firing threshold was the major cause of the increased neuronal variability, for which a decrease in basal ambient GABA concentration was responsible. We suggest that ambient GABA in the brain may have a role in reducing the variability in ongoing-spontaneous neuronal activity, leading to a decrease in perceptual variability and therefore to reliable sensory perception.

show abstract

Regulation of Local Ambient GABA Levels via Transporter-Mediated GABA Import and Export for Subliminal Learning

Cited by 5 publications

References 40 publications

GABA diffusion across neuronal columns for efficient sensory tuning

GABA diffusion across neuronal columns for efficient sensory tuning

Improvement of Sensory Information Processing by Balancing Tonic and Phasic Subthreshold Neuronal Excitation

Reduction of Trial-to-Trial Perceptual Variability by Intracortical Tonic Inhibition

Contact Info

Product

Resources

About